Klhl42 (kelch like family member 42)

Gene: Klhl42 (kelch like family member 42) Ictidomys tridecemlineatus

Analyze

Symbol:

Klhl42

Name:

kelch like family member 42

RGD ID:

12691704

Description:

ENCODES a protein that exhibits ubiquitin-protein transferase activity (ortholog); INVOLVED IN proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); protein polyubiquitination (inferred); regulation of microtubule-based process (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN Cul3-RING ubiquitin ligase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

kelch-like protein 42

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	81,906,209 - 81,928,294 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936760	5,043 - 27,134 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936760	5,049 - 27,134 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein polyubiquitination (IEA)

regulation of microtubule-based process (IEA)

Cellular Component

Cul3-RING ubiquitin ligase complex (IEA)

Molecular Function

protein binding (ISO)

ubiquitin-protein transferase activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Klhl42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	81,906,209 - 81,928,294 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936760	5,043 - 27,134 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936760	5,049 - 27,134 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLHL42
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	27,780,233 - 27,803,040 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	27,780,048 - 27,803,040 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	27,933,166 - 27,955,973 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	27,824,454 - 27,847,240 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	27,824,453 - 27,847,239	NCBI
Celera	12	33,078,741 - 33,101,539 (+)	NCBI		Celera
Cytogenetic Map	12	p11.22	NCBI
HuRef	12	27,702,261 - 27,724,953 (+)	NCBI		HuRef
CHM1_1	12	27,898,197 - 27,920,989 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	27,651,947 - 27,674,765 (+)	NCBI		T2T-CHM13v2.0

Klhl42
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	146,990,783 - 147,014,276 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	146,992,877 - 147,014,276 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	147,090,615 - 147,112,778 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	147,091,379 - 147,112,778 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	147,039,597 - 147,061,300 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	147,048,245 - 147,069,948 (+)	NCBI		MGSCv36	mm8
MGSCv36	6	147,813,510 - 147,836,215 (+)	NCBI		MGSCv36	mm8
Celera	6	150,124,798 - 150,146,756 (+)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	77.7	NCBI

Klhl42
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	181,730,343 - 181,760,899 (+)	NCBI		GRCr8
mRatBN7.2	4	179,999,655 - 180,027,283 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	180,004,580 - 180,027,283 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	186,289,206 - 186,311,270 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	182,073,713 - 182,095,779 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	180,694,163 - 180,716,223 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	181,481,147 - 181,502,916 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	181,481,147 - 181,502,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	245,631,025 - 245,652,794 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	184,688,926 - 184,709,859 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	168,498,092 - 168,519,056 (+)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

Klhl42
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955505	7,043,000 - 7,077,062 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955505	7,046,274 - 7,078,175 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLHL42
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	69,011,497 - 69,034,332 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	69,007,894 - 69,030,754 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	58,509,031 - 58,531,891 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	61,127,167 - 61,149,122 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	61,127,167 - 61,149,126 (-)	Ensembl	panpan1.1		panPan2

KLHL42
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	19,945,465 - 19,962,742 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	19,947,481 - 19,962,924 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	26,437,528 - 26,457,701 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	20,136,377 - 20,156,288 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	20,136,883 - 20,156,255 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	19,942,906 - 19,963,022 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	19,969,802 - 19,989,679 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	26,594,868 - 26,614,758 (+)	NCBI		UU_Cfam_GSD_1.0

KLHL42
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	45,933,928 - 45,954,881 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	45,929,854 - 45,954,887 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	49,503,613 - 49,522,985 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KLHL42
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	27,502,268 - 27,522,280 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	27,502,022 - 27,520,136 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	7,527,767 - 7,550,439 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Klhl42
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624935	186,464 - 254,951 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624935	181,511 - 254,738 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005339926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000028235 ⟹ ENSSTOP00000017781

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936760	5,043 - 27,134 (+)	Ensembl

RefSeq Acc Id:

XM_005339926 ⟹ XP_005339983

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404945	81,906,209 - 81,928,294 (-)	NCBI
SpeTri2.0	NW_004936760	5,049 - 27,134 (+)	NCBI

Sequence:

show sequence

GAGCCGCGGCCCCGGCGGACACCAAGAGGAGGGACTGTCCGAGAGCCCGGCCGAGCGCGGGAGC
GGGCGGCCCTTTGCCTCCTGCTCCTGCCGGGCCGCCATCCCTCGGCGCGCCCTACCCGGAACCA
GGCGAGCGCGTGGGGGCGGGGAGACGAGCGCGCAGAGCTGGCGGGGAGCCCCCAGACCCCCGGG
GCCCCAGCCATGTCGGCGGAGGAGATGGTGCAGATCCGCCTGGAGGACCGCTGCTACCCGGTGA
GCAAGAGGAAGCTCATCGAGCAGAGCGATTACTTCCGCGCCCTCTACCGCTCCGGCATGCGGGA
GGCCCTGAGCCAGGAAGCTGGCGGCCCGGAGGTGCAGCAGCTGCGCGGCCTCAGCGCGCCGGGC
CTGCGGCTGGTGCTGGACTTCATCAATGCCGGCGGGGCCCGCGAAGGCTGGCTCCTGGGCCCGC
GGGGGGAGAAGGGCGGAGGGCTGGAGGAGGAAGAGGACATGGACGAGGTGAGCCTGCTGTCTGA
GCTGGTGGAAGCAGCCTCCTTCCTGCAGGTCACGTCCCTACTGCAGCTGCTGCTGTCCCAAGTG
CGGCTCAACAACTGCCTGGAAATGTACCGCCTGGCGCAGGTGTACGGGCTTCCAGATCTGCAGG
AGGCCTGCCTGCGCTTCATGGTCGTCCACTTCCACGAGGTGTTGTGCAAGCCCCAGTTCCACCT
CCTGGTGTCTCCTCCCCAAGCTCCGGGGGACATCAGCCTGAAGCAGAGGCTGAGGGAGGCCCGG
ATGACTGGGACTCCTGTCCTTGTGGCCCTGGGGGACTTCCTGGGAGGACCCCTGGCCCCTCATC
CCTACCAGGGAGAGCCCCCGTCCATGCTCAGGTATGAGGAGATGACTGAGCGTTGGTTCCCGCT
GGCCAATAACCTGCCTCCCGATCTGGTGAATGTCAGGGGTTATGGGTCAGCCATCCTGGACAAC
TACCTCTTCATAGTGGGCGGGTACAGAATCACTAGCCAGGAGATCTCCGCTGCACATTCCTACA
ACCCCAGCACCAACGAGTGGCTCCAGGTGGCCTCCATGAACCAGAAGAGGTCTAACTTCAAACT
CGTGGCTGTTAATTCAAAACTCTATGCCATTGGCGGGCAGGCCGTTTCTAATGTTGAGTGTTAC
AATCCTGAGCAGGATGCATGGAATTTTGTGGCACCCTTACCAAATCCTCTGGCCGAGTTCTCTG
CGTGTGAGTGTAAGGGGAAAATTTATGTCATTGGAGGATATACTACCAGAGACCGAAACATGAA
CATTTTGCAGTACTGCCCCTCTTCAGACATCTGGACACTCTTTGAAACATGTGACGTCCACATT
CGAAAGCAGCAGATGGTGTCTGTGGAGGAAACCATCTACATTGTCGGGGGATGTCTCCACGAAC
TGGGACCCAACCGGAGGAGCAGCCAGAGCGAGGACATGCTCACTGTGCAGTCCTACAACACTGT
CACCCGGCAGTGGCTCTACCTCAAGGAGAACACATCCAAATCCGGGCTTAACTTGACTTGCGCG
CTCCACAATGACGGCATCTACATCATGAGCAGGGATGTGACCCTGTCCACCAGCTTGGAGCACC
GAGTTTTCCTCAAGTACAATATCTTTTCAGATAGCTGGGAAGCATTTCGGCGATTCCCAGCCTT
TGGACATAACTTGCTGGTTTCTTCTCTTTATCTGCCCAATAAAGCAGAAACATGACTGAATTGA
CTTCGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005339983	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000017781.2
GenBank Protein	KAG3292226	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005339983 ⟸ XM_005339926

- UniProtKB:

I3N085 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSAEEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPEVQQLRGLSAPGLRL
VLDFINAGGAREGWLLGPRGEKGGGLEEEEDMDEVSLLSELVEAASFLQVTSLLQLLLSQVRLN
NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLVSPPQAPGDISLKQRLREARMTG
TPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLVNVRGYGSAILDNYLF
IVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPE
QDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDIWTLFETCDVHIRKQ
QMVSVEETIYIVGGCLHELGPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHN
DGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWEAFRRFPAFGHNLLVSSLYLPNKAET

hide sequence

RefSeq Acc Id:

ENSSTOP00000017781 ⟸ ENSSTOT00000028235

Protein Domains

BTB

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000022449	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028235.2	UniProtKB/TrEMBL
Gene3D-CATH	2.120.10.80	UniProtKB/TrEMBL
InterPro	BACK	UniProtKB/TrEMBL
	BTB/POZ_dom	UniProtKB/TrEMBL
	Kelch-typ_b-propeller	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
	KLHL42_BACK	UniProtKB/TrEMBL
	SKP1/BTB/POZ_sf	UniProtKB/TrEMBL
NCBI Gene	Klhl42	ENTREZGENE
PANTHER	KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 13-RELATED	UniProtKB/TrEMBL
	KELCH-LIKE FAMILY, MEMBER 42	UniProtKB/TrEMBL
Pfam	BACK	UniProtKB/TrEMBL
	Kelch_1	UniProtKB/TrEMBL
PROSITE	BTB	UniProtKB/TrEMBL
SMART	Kelch	UniProtKB/TrEMBL
Superfamily-SCOP	SSF117281	UniProtKB/TrEMBL
	SSF54695	UniProtKB/TrEMBL
UniProt	I3N085	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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