Prtfdc1 (phosphoribosyl transferase domain containing 1)

Gene: Prtfdc1 (phosphoribosyl transferase domain containing 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Prtfdc1

Name:

phosphoribosyl transferase domain containing 1

RGD ID:

12643457

Description:

ENCODES a protein that exhibits hypoxanthine phosphoribosyltransferase activity (ortholog); INVOLVED IN GMP catabolic process (ortholog); guanine salvage (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); Mouth Neoplasms (ortholog); Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

phosphoribosyl transferase domain containing 1, transcript variant X1; phosphoribosyl transferase domain containing 1, transcript variant X2; phosphoribosyltransferase domain-containing protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	24,402,890 - 24,485,471 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	566,543 - 650,896 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	568,056 - 650,820 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Mouth Neoplasms (ISO)

Ovarian Neoplasms (ISO)

squamous cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

GMP catabolic process (ISO)

GMP salvage (IEA)

guanine salvage (IEA,ISO)

hypoxanthine metabolic process (IEA)

IMP salvage (IEA)

purine ribonucleoside salvage (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

Molecular Function

glycosyltransferase activity (IEA)

guanine phosphoribosyltransferase activity (IEA)

hypoxanthine phosphoribosyltransferase activity (IEA,ISO)

magnesium ion binding (IEA)

metal ion binding (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Prtfdc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	24,402,890 - 24,485,471 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	566,543 - 650,896 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	568,056 - 650,820 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRTFDC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	24,848,614 - 24,952,606 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	24,848,614 - 24,952,606 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	25,137,543 - 25,241,535 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	25,177,560 - 25,281,539 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	25,177,559 - 25,281,539	NCBI
Celera	10	24,838,423 - 24,942,409 (-)	NCBI		Celera
Cytogenetic Map	10	p12.1	NCBI
HuRef	10	24,799,013 - 24,902,637 (-)	NCBI		HuRef
CHM1_1	10	25,138,118 - 25,242,059 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	24,866,903 - 24,970,863 (-)	NCBI		T2T-CHM13v2.0

Gm13377
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	21,049,620 - 21,144,493 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	21,049,619 - 21,146,765 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	21,044,809 - 21,139,682 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	21,044,808 - 21,141,954 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	20,966,435 - 21,061,308 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	20,966,435 - 21,061,308 (-)	NCBI		MGSCv36	mm8
Celera	2	20,929,324 - 21,017,413 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	14.73	NCBI

Prtfdc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	88,457,872 - 88,563,109 (-)	NCBI		GRCr8
mRatBN7.2	17	83,549,608 - 83,654,517 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	83,548,803 - 83,655,179 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	87,029,561 - 87,127,894 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	90,864,956 - 90,963,271 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	84,881,888 - 84,980,212 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	87,926,242 - 88,037,040 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	87,927,058 - 88,037,040 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	89,615,538 - 89,724,742 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	95,021,578 - 95,140,362 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	95,031,593 - 95,151,192 (-)	NCBI
Celera	17	82,809,745 - 82,908,068 (-)	NCBI		Celera
Cytogenetic Map	17	q12.3	NCBI

Prtfdc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955429	4,234,806 - 4,325,896 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRTFDC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	37,488,479 - 37,652,082 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	37,531,998 - 37,657,392 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	25,023,015 - 25,127,770 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	25,393,227 - 25,497,054 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	25,393,227 - 25,497,054 (-)	Ensembl	panpan1.1		panPan2

PRTFDC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	8,551,008 - 8,643,710 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	8,559,319 - 8,642,533 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	7,245,705 - 7,339,234 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	6,750,858 - 6,844,460 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	6,750,953 - 6,844,460 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	6,120,472 - 6,213,933 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	6,197,179 - 6,290,517 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	6,365,431 - 6,458,849 (+)	NCBI		UU_Cfam_GSD_1.0

PRTFDC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	50,365,587 - 50,461,324 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	50,365,654 - 50,458,487 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	55,787,876 - 55,911,201 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PRTFDC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	24,568,867 - 24,678,020 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	24,568,692 - 24,677,550 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	30,505,955 - 30,638,727 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prtfdc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624796	4,014,076 - 4,095,920 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021722979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040277611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040277612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005730589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005730590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000038724 ⟹ ENSSTOP00000025244

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936484	566,543 - 650,896 (-)	Ensembl

RefSeq Acc Id:

XM_005320242 ⟹ XP_005320299

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	24,403,720 - 24,485,471 (-)	NCBI
SpeTri2.0	NW_004936484	568,355 - 650,820 (-)	NCBI

Sequence:

show sequence

CGAGCAGGCGGCGGGGCTCACGAGCTCGCAGACGGACACGCGGCAGGCGGCAGCCGCCAGGGAC
GCGCCCGGGGCCTGCGCTCAGGTGGAGCGGGCGCTGCTCCGCAGCTGCTCCCCGCGCTGCGCCC
CGGGGACCCGCGGGGGTAGGGGGCGCGGCGGCCGAGGCGCTGGCGCCGCGCCAGGCTTGCTTTC
CCGCCGGCTGGCCGAGGGCGGGGCGGCCCCGGTCCCATCCCCCAGCCCAGCCCGGGCCTCCCGG
ATCCTTCCCGCGCCGGTCTTTCCTTCCCGCTTTCCCCGGGAGAAACATGGCCGGGAGCACGGAG
GAGGCGCCAGACTGCGGGCGAGGCGTCGTGATTACAGACAGCTGGCCAGGGTACGACTTAGATT
TGTTCACATACCCACAGCACTATTACGGAGATTTGGAATATGTACTCATACCCCATGGCATCAT
TGTGGACAGAATTGAGCGGCTGGCAAAGGATATAATGAAAGACATTGGATACTGCGACATTATG
GTCCTGTGTGTACTTAAAGGTGGTTACAAATTCTGTGCTGATCTTGTAGAACACCTTAAGAACA
TCAGCCGAAATTCAGATCGGTTTGTCTCTATGAAGGTTGATTTCATCAGACTAAAAAGTTACAA
GAATGATCAATCCATGGGCGAGATGCAGATAATTGGAGGCGAGGATCTTTCAACGCTGGCTGGA
AAGAATGTCCTCATTGTTGAGGATGTCGTTGGAACTGGGAGGACCATGAAAGCCCTGCTCACCA
GCATAAAGAAATACAAGCCCAACATGATTAAGGTAGCCAGTTTGTTGGTAAAGAGAACACCTAG
AAGCGATGGCTTTAGACCTGACTATGCTGGATTTGAGATTCCAAACTTATTTGTGGTGGGATAT
GCCTTAGATTACAATGAGTACTTCAGAGATCTGAATCACATCTGCGTGATCAATGAACACGGTA
AAGAAAAATATCGAGTCTGAAGAAGCAAATTCTTACCATCAACTTCCCAGATAACATCGTTCTT
ACTACTATACTACACTCAGGAAGCCAGCCCATAAAATCTGTCTCCCCGGGCGACTTCACGCAAC
AGGATGTAAAAGAAAAAAAAAAAACGTTTTAAGTGAAAGCTTTCTTTTCTGAGATATAAAGAGT
ACTAAAGGTTCTTAAGGAAAAGAAAGCAGTGCTTTTATTTGACTTGTTCCAAATTCAACACTCC
ACCTTATGACTCATAAGTTCTCTCCACCTTCACACTCCTGAGTTACACCTTCTTTTGTTTTGAT
AATCATTATGCTTGACTACCATTCCCAGGAATACCCCCACTTAGTTACTCAAATATTTTTCACC
TAACTTTTTTTTAACACCTTAATTTTGTAATATTTTATACTATTAAGAACTGAGAAACTTTTTA
AAGTAAGTCCTGAAGAACTGACATACTAGGAATGCAGCTAGATTCCCATGCTAAAAAAGGGAGG
GAAAGAATAACTTAGTATAAATTCCTGTTTGCGCCTCTCTGACAGGACATCATTATCTGCTGTG
ACAAGGCCTTTCAGAAAGGCAGGGTAGGATGAATCTTAATGATGTTATGAAATGAGCCTTTGCT
TAGTGCTCTTGATCAGAGCTTCCGGTATGTGATGACAGTGTGTCGTGTATGCATGGATGTACTC
AACTGTGTTTAATACTCTGAATTTTAATTAGAAAA

hide sequence

RefSeq Acc Id:

XM_040277611 ⟹ XP_040133545

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	24,402,890 - 24,479,782 (-)	NCBI

RefSeq Acc Id:

XM_040277612 ⟹ XP_040133546

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	24,451,193 - 24,479,985 (-)	NCBI

RefSeq Acc Id:

XR_005730589

Type:

NON-CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	24,450,866 - 24,479,985 (-)	NCBI

RefSeq Acc Id:

XR_005730590

Type:

NON-CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	24,451,193 - 24,479,985 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005320299	(Get FASTA)	NCBI Sequence Viewer
	XP_040133545	(Get FASTA)	NCBI Sequence Viewer
	XP_040133546	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000025244.1
GenBank Protein	KAG3257631	(Get FASTA)	NCBI Sequence Viewer
	KAG3257632	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005320299 ⟸ XM_005320242
- Peptide Label:	isoform X3
- UniProtKB:	A0A287CVE2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGSTEEAPDCGRGVVITDSWPGYDLDLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDI GYCDIMVLCVLKGGYKFCADLVEHLKNISRNSDRFVSMKVDFIRLKSYKNDQSMGEMQIIGGED LSTLAGKNVLIVEDVVGTGRTMKALLTSIKKYKPNMIKVASLLVKRTPRSDGFRPDYAGFEIPN LFVVGYALDYNEYFRDLNHICVINEHGKEKYRV hide sequence

RefSeq Acc Id:	XP_040133545 ⟸ XM_040277611
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040133546 ⟸ XM_040277612
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000025244 ⟸ ENSSTOT00000038724

Protein Domains

Phosphoribosyltransferase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000033462	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000038724.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.2020	UniProtKB/TrEMBL
InterPro	Hxn_phspho_trans	UniProtKB/TrEMBL
	PRibTrfase_dom	UniProtKB/TrEMBL
	PRTase-like	UniProtKB/TrEMBL
NCBI Gene	Prtfdc1	ENTREZGENE
PANTHER	HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE	UniProtKB/TrEMBL
	PHOSPHORIBOSYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
Pfam	Pribosyltran	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53271	UniProtKB/TrEMBL
UniProt	A0A287CVE2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD