Pla2g2a (phospholipase A2 group IIA) - Rat Genome Database

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Gene: Pla2g2a (phospholipase A2 group IIA) Ictidomys tridecemlineatus
Analyze
Symbol: Pla2g2a
Name: phospholipase A2 group IIA
RGD ID: 12573709
Description: ENCODES a protein that exhibits calcium-dependent phospholipase A2 activity (ortholog); INVOLVED IN cell population proliferation (ortholog); intestinal stem cell homeostasis (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN glypican signaling pathway; indometacin pharmacodynamics pathway; indometacin pharmacodynamics pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); Acute Lung Injury (ortholog); Adrenal Insufficiency (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phospholipase A2, membrane associated
RGD Orthologs
Human
Mouse
Rat
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,267,196 - 40,271,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,091,941 - 6,096,057 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,091,978 - 6,095,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pla2g2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,267,196 - 40,271,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,091,941 - 6,096,057 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,091,978 - 6,095,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38119,975,431 - 19,980,434 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl119,975,431 - 19,980,416 (-)EnsemblGRCh38hg38GRCh38
GRCh37120,301,924 - 20,306,927 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,174,518 - 20,179,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 34120,047,239 - 20,052,215NCBI
Celera118,628,736 - 18,633,743 (-)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef118,547,710 - 18,552,716 (-)NCBIHuRef
CHM1_1120,411,642 - 20,416,650 (-)NCBICHM1_1
T2T-CHM13v2.0119,799,116 - 19,804,113 (-)NCBIT2T-CHM13v2.0
Pla2g2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,559,168 - 138,562,500 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,559,171 - 138,562,497 (+)EnsemblGRCm39 Ensembl
GRCm384138,831,857 - 138,835,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,831,857 - 138,835,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv374138,387,772 - 138,391,104 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,103,933 - 138,107,259 (+)NCBIMGSCv36mm8
Celera4140,618,192 - 140,621,524 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.57NCBI
Pla2g2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,359,725 - 156,362,302 (+)NCBIGRCr8
mRatBN7.25151,076,442 - 151,079,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,076,442 - 151,079,014 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,773,843 - 153,776,420 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,548,152 - 155,550,729 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,529,916 - 155,532,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,282,650 - 157,285,295 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,282,669 - 157,285,328 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05161,024,039 - 161,026,650 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,654,786 - 157,657,360 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,664,332 - 157,667,400 (+)NCBI
Celera5149,464,001 - 149,466,577 (+)NCBICelera
Cytogenetic Map5q36NCBI
PLA2G2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21207,109,330 - 207,143,737 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,226,298 - 206,260,589 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0118,930,294 - 18,934,563 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1119,973,352 - 19,977,627 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl119,971,084 - 19,977,627 (-)Ensemblpanpan1.1panPan2
PLA2G2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,327,319 - 78,330,699 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,327,728 - 78,339,546 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,517,061 - 72,556,712 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,564,414 - 112,569,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,565,165 - 112,569,786 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660333,610,631 - 3,615,025 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,144,549 - 5,151,995 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,144,549 - 5,152,517 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005317537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000021550   ⟹   ENSSTOP00000019146
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364746,091,941 - 6,096,057 (-)Ensembl
RefSeq Acc Id: XM_005317537   ⟹   XP_005317594
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505840,267,196 - 40,271,190 (-)NCBI
SpeTri2.0NW_0049364746,091,978 - 6,095,961 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005317594 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000019146.1
GenBank Protein KAG3282302 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005317594   ⟸   XM_005317537
- UniProtKB: I3N450 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000019146   ⟸   ENSSTOT00000021550
Protein Domains
Phospholipase A2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000022385 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021550.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLipase_A2 UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
NCBI Gene Pla2g2a ENTREZGENE
PANTHER PHOSPHOLIPASE A2, MEMBRANE ASSOCIATED UniProtKB/TrEMBL
  PTHR11716 UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/TrEMBL
PRINTS PHPHLIPASEA2 UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/TrEMBL
  PA2_HIS UniProtKB/TrEMBL
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt I3N450 ENTREZGENE, UniProtKB/TrEMBL