Tktl1 (transketolase like 1) - Rat Genome Database

Name: Tktl1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Tktl1 (transketolase like 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Tktl1

Name:

transketolase like 1

RGD ID:

12487747

Description:

ENCODES a protein that exhibits catalytic activity (inferred); thiamine pyrophosphate binding (inferred); transferase activity (inferred); ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); Barth syndrome (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transketolase like 1, transcript variant X1; transketolase like 1, transcript variant X2; transketolase-like protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TKTL1 (transketolase like 1)	NCBI	Ortholog
Mus musculus (house mouse):	Tktl1 (transketolase-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tktl1 (transketolase-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tktl1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tktl1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,310,855 - 119,346,858 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	1,048,672 - 1,083,994 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	1,048,672 - 1,084,125 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

favism (ISO)

frontometaphyseal dysplasia (ISO)

genetic disease (ISO)

immunodeficiency 33 (ISO)

Juberg Hayward Syndrome (ISO)

Melnick-Needles syndrome (ISO)

methylmalonic acidemia and homocysteinemia cblX type (ISO)

otopalatodigital syndrome type 2 (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

Periventricular Nodular Heterotopia 4 (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

Molecular Function

catalytic activity (IEA)

thiamine pyrophosphate binding (IEA)

transferase activity (IEA)

transketolase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Tktl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,310,855 - 119,346,858 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	1,048,672 - 1,083,994 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	1,048,672 - 1,084,125 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TKTL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	154,295,795 - 154,330,350 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	154,295,795 - 154,330,350 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	153,524,148 - 153,558,700 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	153,177,345 - 153,211,894 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	153,044,997 - 153,079,545	NCBI
Celera	X	153,685,095 - 153,719,771 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	142,101,239 - 142,134,950 (+)	NCBI		HuRef
CHM1_1	X	153,435,658 - 153,470,347 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	152,532,310 - 152,566,865 (+)	NCBI		T2T-CHM13v2.0

Tktl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	73,220,865 - 73,252,104 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	73,220,865 - 73,252,106 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	74,177,259 - 74,208,498 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	74,177,259 - 74,208,500 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	71,422,598 - 71,453,837 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	70,430,004 - 70,461,211 (+)	NCBI		MGSCv36	mm8
Celera	X	65,429,659 - 65,462,614 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.83	NCBI

Tktl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,105,455 - 157,138,510 (+)	NCBI		GRCr8
mRatBN7.2	X	151,954,261 - 151,987,208 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,954,175 - 151,987,208 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,095,403 - 154,128,342 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,658,639 - 157,691,577 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,330,437 - 155,363,375 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,507,797 - 156,540,733 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,507,797 - 156,540,733 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,248,857 - 152,281,793 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	1	151,506,633 - 151,523,468 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,144,916 - 160,177,852 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	135,909,517 - 135,940,852 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

Tktl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	829,594 - 851,470 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	829,653 - 851,422 (+)	NCBI	ChiLan1.0	ChiLan1.0

TKTL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	154,263,474 - 154,304,907 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	154,267,079 - 154,308,512 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,736,589 - 143,772,277 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TKTL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	122,007,270 - 122,034,500 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	122,007,282 - 122,034,255 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	107,336,003 - 107,363,191 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	125,148,940 - 125,176,143 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	125,148,958 - 125,176,646 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	120,918,050 - 120,945,228 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	123,433,366 - 123,460,383 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	123,194,859 - 123,221,957 (+)	NCBI		UU_Cfam_GSD_1.0

TKTL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,839,995 - 124,867,614 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,840,072 - 124,867,313 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TKTL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	128,607,766 - 128,642,074 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	128,607,901 - 128,642,063 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	66,535,359 - 66,559,996 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tktl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624946	760,078 - 775,073 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005340632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005340633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000005020 ⟹ ENSSTOP00000004502

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936809	1,048,672 - 1,083,994 (+)	Ensembl

RefSeq Acc Id:

XM_005340632 ⟹ XP_005340689

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	119,310,855 - 119,346,858 (+)	NCBI
SpeTri2.0	NW_004936809	1,048,672 - 1,084,125 (+)	NCBI

Sequence:

show sequence

ATGTCTGATATTGAGGCTGGCAGTTTGATGGCCAAGGAGGCCAGACCCGACGAGAAGACAGTGC
AGGTGTTGCGGGATATGGCTAACCGCCTGCGCATCCATTCCATCAGGGCCACTTGCGCTTCGAG
CTCCGGCCACCCTACATCATGCAGCAGTGCTGCTGAGATCATGTCTGTGCTTTTCTTCCACACG
ATGAGATATAAACAGTCAGACCCAGAGAACCCAGACAACGACCGATTCATCCTCTCAAAGAGAC
TGTCCTTTGTTGATGTGGCAACAGGATGGCTTGGGCAAGGACTGGGGGCTGCGTGTGGGATGGC
ATATACTGGCAAGTACTTTGACCAGGCCAGCTACCGTGTGTTCTGCCTCCTGGGAGATGGTGAG
TCGTCTGAAGGCTCTGTCTGGGAGGCATTGGCCTTCGCTTCCTACTACAGTCTGGATAATCTTG
TGGTGATCTTTGATGTGAACCGCCTGGGACATGGTGGCACCTTGCCCCTTGAGCACTGCATAGA
AGTCTATCAGAAGCGCTGTGAAGCCTTTGGGTGGAACACTTATGTGGTGGATGGTCGTGATGTG
GAGGCACTGTGCCAGGTGTTCTGGCAAGCAGCCCAAGTGAAAAGCAAGCCCACTGCCGTGGTTG
CCAAGACCTTCAAGGGCCGGGGCATGCCAAATGTTGAAGATGCAGAAAATTGGTATGGAAAACC
AATGCCAAAAGAAAGAGCAGATGCAATTATCAAATTAATTGAGAGCCAGATACAGACCAACAGG
AGTCTTTTACCACAACCCCCTATTGAGGATTCACCTCAAGTCAATATCATGGATATAAAAATGA
CCTGTCCACCTGCTTATGAAGTTGGCGATGTGGTAGCTACTCGAAAAGCATGTGGTTTGGCTCT
AGCTAAGCTGGGCCATGCAAACAACAGAGTCATTGTGCTGGATGGTGACACCAAGAACTCCACC
TTCTCTGAGATATTCAAGAAAGAACACCCTGAACGATTCATCGAGTGTTTTATTGCTGAGCAAA
ACATGGTGAGCGTGGCACTGGGCTGTGCCACCCGTGGTCGGACCATTGCTTTTGCTAGCACTTT
TGCTGCCTTTTTGACCCGAGCATTTGATCAGATCCGCATGGGAGCCATCGCTCAAATCAACATC
AACCTTATTGGTTCTCACTGTGGGGTGTCCGTTGGTGAAGATGGCCCTTCCCAGATGGCCCTGG
AAGATCTGGCTATGTTCCGAGCAGTTCCCAACTGCACTATTTTTTATCCAAGTGATGCTGTCTC
CACGGAACATGCTATTTATTTAGCAGCCAATACCAAGGGAATGTGTTTCATTCGAACCAGCCGG
CCAGAAACTGCAGTTCTTTATACCCCTCAAGAAACCTTTAAGATTGGACAGGCTAAGGTTGTCC
GCCAAAGTGTCAATGACAAAGTCACGGTTATTGGAGCTGGAATTACTCTGCATGAAGCCTTAGT
GGCTGCTGATGATCTCTCTAAACAAGATATTTTTATCCGTGTCATTGATCTGTTTACCATTAAA
CCCCTGGATGTTGCCACCATCATTTCCAATGCAAGAGCCACAGGCGGCCGGATTATCACAGTGG
AGGATCACTACCCAGAAGGTGGCATTGGGGAAGCTGTCTCTGCAGCTGTCTCCATGGAGCCTGA
CATCCTGGTTCATCAGCTGGCAGTGATGGGAGTGCCTCGGAGCGGGAGACCCAGCGAGCTGCTG
GATACATTTGGAATCAGTGCCAGACACATCATTGTGGCTGTGAAATGCATGTTGATGAACTAAA
ATAGCTGTTGATTCTGTCTTAGAAGACTGGCCTCTGTACCTTATATTTAGGCTTGTTCTAAAAC
CATTGTTGAAACTCTTGACCTTTGCTCTCCTTAAAGCCAGCTAACACCTTTCTTCATTCCTAAT
TC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005340689	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004502.3
GenBank Protein	KAG3273226	(Get FASTA)	NCBI Sequence Viewer
	KAG3273227	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005340689 ⟸ XM_005340632

- UniProtKB:

I3M5B2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSDIEAGSLMAKEARPDEKTVQVLRDMANRLRIHSIRATCASSSGHPTSCSSAAEIMSVLFFHT
MRYKQSDPENPDNDRFILSKRLSFVDVATGWLGQGLGAACGMAYTGKYFDQASYRVFCLLGDGE
SSEGSVWEALAFASYYSLDNLVVIFDVNRLGHGGTLPLEHCIEVYQKRCEAFGWNTYVVDGRDV
EALCQVFWQAAQVKSKPTAVVAKTFKGRGMPNVEDAENWYGKPMPKERADAIIKLIESQIQTNR
SLLPQPPIEDSPQVNIMDIKMTCPPAYEVGDVVATRKACGLALAKLGHANNRVIVLDGDTKNST
FSEIFKKEHPERFIECFIAEQNMVSVALGCATRGRTIAFASTFAAFLTRAFDQIRMGAIAQINI
NLIGSHCGVSVGEDGPSQMALEDLAMFRAVPNCTIFYPSDAVSTEHAIYLAANTKGMCFIRTSR
PETAVLYTPQETFKIGQAKVVRQSVNDKVTVIGAGITLHEALVAADDLSKQDIFIRVIDLFTIK
PLDVATIISNARATGGRIITVEDHYPEGGIGEAVSAAVSMEPDILVHQLAVMGVPRSGRPSELL
DTFGISARHIIVAVKCMLMN

hide sequence

RefSeq Acc Id:

ENSSTOP00000004502 ⟸ ENSSTOT00000005020

Protein Domains

Transketolase-like pyrimidine-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005014	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005020.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.920	UniProtKB/TrEMBL
	3.40.50.970	UniProtKB/TrEMBL
InterPro	THDP-binding	UniProtKB/TrEMBL
	Transketo_C/PFOR_II	UniProtKB/TrEMBL
	Transketolase-like_Pyr-bd	UniProtKB/TrEMBL
	Transketolase_BS	UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/TrEMBL
	Transketolase_N	UniProtKB/TrEMBL
NCBI Gene	Tktl1	ENTREZGENE
PANTHER	TRANSKETOLASE	UniProtKB/TrEMBL
	TRANSKETOLASE-LIKE PROTEIN 1	UniProtKB/TrEMBL
Pfam	Transket_pyr	UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/TrEMBL
	Transketolase_N	UniProtKB/TrEMBL
PROSITE	TRANSKETOLASE_2	UniProtKB/TrEMBL
SMART	Transket_pyr	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52518	UniProtKB/TrEMBL
	SSF52922	UniProtKB/TrEMBL
UniProt	I3M5B2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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