Acot8 (acyl-CoA thioesterase 8) - Rat Genome Database

Name: Acot8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Acot8 (acyl-CoA thioesterase 8) Ictidomys tridecemlineatus

Analyze

Symbol:

Acot8

Name:

acyl-CoA thioesterase 8

RGD ID:

12475233

Description:

ENCODES a protein that exhibits choloyl-CoA hydrolase activity (ortholog); long-chain fatty acyl-CoA hydrolase activity (ortholog); INVOLVED IN acyl-CoA metabolic process (ortholog); ASSOCIATED WITH focal epilepsy (ortholog); T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ortholog); FOUND IN cytosol (inferred); peroxisomal matrix (inferred); peroxisome (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

acyl-CoA thioesterase 8, transcript variant X1; acyl-CoA thioesterase 8, transcript variant X2; acyl-CoA thioesterase 8, transcript variant X3; acyl-coenzyme A thioesterase 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	191,713,172 - 191,726,893 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	7,166,818 - 7,180,537 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	7,166,392 - 7,180,537 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal epilepsy (ISO)

T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acyl-CoA metabolic process (IEA,ISO)

dicarboxylic acid catabolic process (IEA)

fatty acid catabolic process (IEA)

negative regulation of CD4 production (IEA)

peroxisome fission (IEA)

Cellular Component

cytosol (IEA)

peroxisomal matrix (IEA)

peroxisome (IEA)

Molecular Function

choloyl-CoA hydrolase activity (ISO)

fatty acyl-CoA hydrolase activity (IEA)

hydrolase activity (IEA)

long-chain fatty acyl-CoA hydrolase activity (IEA,ISO)

medium-chain fatty acyl-CoA hydrolase activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Acot8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	191,713,172 - 191,726,893 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	7,166,818 - 7,180,537 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	7,166,392 - 7,180,537 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ACOT8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	45,841,721 - 45,857,392 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	45,841,721 - 45,857,405 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	44,470,360 - 44,486,031 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	43,903,768 - 43,919,442 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	43,903,767 - 43,919,442	NCBI
Celera	20	41,180,856 - 41,196,530 (-)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	41,212,129 - 41,227,770 (-)	NCBI		HuRef
CHM1_1	20	44,373,492 - 44,389,180 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	47,578,222 - 47,593,911 (-)	NCBI		T2T-CHM13v2.0

Acot8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	164,634,688 - 164,662,132 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	164,634,685 - 164,646,802 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	164,792,768 - 164,820,219 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	164,792,765 - 164,804,882 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	164,618,268 - 164,630,381 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	164,483,973 - 164,496,077 (-)	NCBI		MGSCv36	mm8
Celera	2	170,730,175 - 170,742,288 (-)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	85.27	NCBI

Acot8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	173,950,530 - 173,962,188 (-)	NCBI		GRCr8
mRatBN7.2	3	153,531,192 - 153,542,851 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	153,531,193 - 153,542,851 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	157,339,669 - 157,351,337 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	165,838,639 - 165,850,307 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	163,582,412 - 163,594,081 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	161,260,837 - 161,272,495 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	161,259,735 - 161,272,460 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	167,446,048 - 167,457,779 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	155,828,209 - 155,839,862 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	155,734,245 - 155,745,898 (-)	NCBI
Celera	3	152,138,819 - 152,150,462 (-)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Acot8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	11,434,082 - 11,454,806 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	11,434,649 - 11,454,806 (+)	NCBI	ChiLan1.0	ChiLan1.0

ACOT8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	51,583,277 - 51,599,011 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	51,576,385 - 51,592,109 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	42,180,734 - 42,196,466 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	43,268,264 - 43,283,989 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	43,268,264 - 43,283,989 (-)	Ensembl	panpan1.1		panPan2

ACOT8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	33,149,415 - 33,163,086 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	33,128,290 - 33,163,050 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	32,676,438 - 32,690,112 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	33,859,698 - 33,873,388 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	33,859,700 - 33,873,380 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	33,118,251 - 33,131,923 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	33,233,332 - 33,246,997 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	33,772,459 - 33,786,134 (-)	NCBI		UU_Cfam_GSD_1.0

ACOT8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	48,039,628 - 48,054,335 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	48,039,627 - 48,054,335 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	53,685,696 - 53,700,414 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACOT8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	18,026,927 - 18,043,940 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	18,027,016 - 18,043,823 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	66,666,666 - 66,683,894 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013358597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013358598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006529 ⟹ ENSSTOP00000005838

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936514	7,166,818 - 7,180,537 (+)	Ensembl

RefSeq Acc Id:

XM_005325255 ⟹ XP_005325312

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	191,713,172 - 191,726,893 (+)	NCBI
SpeTri2.0	NW_004936514	7,166,818 - 7,180,537 (+)	NCBI

Sequence:

show sequence

GGTAGCTAAGGCAGTCTGCCGGAAGCGCCGGGATCCTATGTAGGTCTCCGTGTGTCCTGCTCAG
AGCGGTGTCCCGACCCACAGCAAGGAAACAAGATGTCGTCCCCACAGGTCCCGGAGGACGGGCA
GGGCAGTGGCGACAGCGGCGATCCCTCCGGGGACCTCCGTAGCGTCCTGGTCACCAGCGTGCTC
AGCCTTGAGCCGCTAGACGAGGATCTCTTCAGAGGAAGGCATTACTGGGTACCCACCACCCAGC
GGCTCTTTGGGGGTCAGATCGTGGGCCAGGCCCTGGTGGCTGCCGCCAAGTCTGTGAGTGAAGA
CATCCACGTGCACTCCCTGCACTGCTACTTTGTCCGGGCAGGAGACCCAAAGGTGCCTGTGCTG
TACCAGGTGGAGCGGACACGAACAGGGTCGAGCTTCTCGGTGCGCTCCGTGAAGGCCGTGCAGC
ATGGCAAGCCCATCTTCATCTTCCAGGCCTCCTTCCAGCAGACCCAGCCCAGCCCTGTGCAGCA
CCAGTTCTCCATGCCTGCTGTGCCACCACCAGAAGAGCTGCTTGACCACCAGGCCCTCATTGAC
CAGTATTTAAGGGACCCTAACCTCAAAGAGAAGTACCGAGTGGGGCTGAACCGAATTGCTGCCC
AGGAGGTACCCATTGAGATCAAGCTGGTAAATCCACCCACCCTGAGCCAGCTGCAGAGAATGGA
GCCCAAACAGATGTTCTGGGTGCGAGCCCGGGGCTATATCGGGGAGGGCGACATCAAGATGCAC
TGCTGCGTGGCCGCTTATATCTCAGACTATGCTTTCCTGGGCACGGCACTGCTGCCCCATCAGT
GGAAACATAAAGTGCACTTCATGGTCTCTCTAGACCACTCTATGTGGTTCCATGCCCCCTTCCG
AGCCGACCACTGGATGCTGTATGAGTGCGAGAGCCCCTGGGCCGGTGGCTCTCGGGGGCTAGTC
CACGGGCGGCTGTGGCGTCGGGATGGGATCCTGGCTGTGTCCTGTGCCCAGGAAGGCGTCATCC
GAGTAAAGCCCAGAGTGTCAGAGAGCAAGCTGTAGCCAGAGGTATCAGCTTGCCTCGGTCTTCA
AGGATCTCCCTTCTACCACCATTCCTGAGGTGGGGCTATGTGGAGGGCTGGACCTTCTGCCCCT
CACACTTAATAAAGAGACTGACACCATTGGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005325312	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000005838.2
GenBank Protein	KAG3263541	(Get FASTA)	NCBI Sequence Viewer
	KAG3263542	(Get FASTA)	NCBI Sequence Viewer
	KAG3263543	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005325312 ⟸ XM_005325255

- UniProtKB:

I3M835 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSPQVPEDGQGSGDSGDPSGDLRSVLVTSVLSLEPLDEDLFRGRHYWVPTTQRLFGGQIVGQA
LVAAAKSVSEDIHVHSLHCYFVRAGDPKVPVLYQVERTRTGSSFSVRSVKAVQHGKPIFIFQAS
FQQTQPSPVQHQFSMPAVPPPEELLDHQALIDQYLRDPNLKEKYRVGLNRIAAQEVPIEIKLVN
PPTLSQLQRMEPKQMFWVRARGYIGEGDIKMHCCVAAYISDYAFLGTALLPHQWKHKVHFMVSL
DHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRRDGILAVSCAQEGVIRVKPRVSESKL

hide sequence

RefSeq Acc Id:

ENSSTOP00000005838 ⟸ ENSSTOT00000006529

Protein Domains

Acyl-CoA thioesterase II Acyl-CoA thioesterase-like N-terminal HotDog

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006540	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006529.3	UniProtKB/TrEMBL
Gene3D-CATH	2.40.160.210	UniProtKB/TrEMBL
InterPro	Acyl-CoA_hotdog	UniProtKB/TrEMBL
	Acyl_CoA_thio	UniProtKB/TrEMBL
	Acyl_CoA_thio_II_dom	UniProtKB/TrEMBL
	HotDog_dom_sf	UniProtKB/TrEMBL
	TesB_ACOT8-like_N	UniProtKB/TrEMBL
NCBI Gene	Acot8	ENTREZGENE
PANTHER	ACYL-COENZYME A THIOESTERASE 8	UniProtKB/TrEMBL
	PTHR11066	UniProtKB/TrEMBL
Pfam	4HBT_3	UniProtKB/TrEMBL
	Acyl_CoA_thio	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54637	UniProtKB/TrEMBL
UniProt	I3M835	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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