Pole4 (DNA polymerase epsilon 4, accessory subunit) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Pole4 (DNA polymerase epsilon 4, accessory subunit) Ictidomys tridecemlineatus
Analyze
Symbol: Pole4
Name: DNA polymerase epsilon 4, accessory subunit
RGD ID: 12470420
Description: ENCODES a protein that exhibits protein heterodimerization activity (inferred); INVOLVED IN DNA-templated DNA replication (inferred); PARTICIPATES IN nucleotide excision repair pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN epsilon DNA polymerase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA polymerase epsilon subunit 4; polymerase (DNA-directed), epsilon 4, accessory subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,569,711 - 9,576,535 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,160,385 - 1,170,843 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,161,359 - 1,167,283 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pole4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,569,711 - 9,576,535 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,160,385 - 1,170,843 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,161,359 - 1,167,283 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLE4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,958,643 - 74,970,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,958,643 - 74,970,128 (+)EnsemblGRCh38hg38GRCh38
GRCh37275,185,770 - 75,197,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36275,039,283 - 75,050,367 (+)NCBINCBI36Build 36hg18NCBI36
Build 34275,097,429 - 75,108,514NCBI
Celera275,017,063 - 75,028,146 (+)NCBICelera
Cytogenetic Map2p12NCBI
HuRef274,922,607 - 74,933,690 (+)NCBIHuRef
CHM1_1275,115,083 - 75,126,167 (+)NCBICHM1_1
T2T-CHM13v2.0274,967,499 - 74,978,982 (+)NCBIT2T-CHM13v2.0
Pole4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,593,513 - 82,629,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,595,973 - 82,682,346 (-)EnsemblGRCm39 Ensembl
GRCm38682,616,532 - 82,653,043 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,618,992 - 82,705,365 (-)EnsemblGRCm38mm10GRCm38
MGSCv37682,596,706 - 82,602,859 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,612,370 - 82,618,523 (-)NCBIMGSCv36mm8
Celera684,622,456 - 84,628,609 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Pole4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,723,040 - 116,728,873 (-)NCBIGRCr8
mRatBN7.24115,165,285 - 115,171,097 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,165,285 - 115,171,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4120,628,783 - 120,634,693 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,403,999 - 116,409,911 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,025,483 - 115,031,343 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,491,644 - 113,497,455 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,491,644 - 113,497,455 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,170,534 - 178,176,366 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44116,856,445 - 116,862,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,101,557 - 117,106,737 (-)NCBI
Celera4104,161,837 - 104,167,648 (-)NCBICelera
Cytogenetic Map4q34NCBI
Pole4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,839,639 - 10,844,985 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542410,839,639 - 10,844,985 (-)NCBIChiLan1.0ChiLan1.0
POLE4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,421,620 - 51,432,858 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,424,374 - 51,435,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A75,023,087 - 75,034,178 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,526,385 - 76,537,463 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,526,385 - 76,537,463 (+)Ensemblpanpan1.1panPan2
POLE4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,241,641 - 48,251,679 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1747,884,498 - 47,894,541 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,082,627 - 49,114,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,104,025 - 49,114,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,097,751 - 48,129,173 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,162,605 - 48,194,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,724,719 - 48,756,385 (-)NCBIUU_Cfam_GSD_1.0
POLE4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,098,587 - 68,117,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,103,028 - 68,117,308 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,280,587 - 71,294,748 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLE4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,313,399 - 32,320,084 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,312,893 - 32,320,016 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,854,804 - 79,914,357 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pole4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,537,001 - 28,547,737 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,538,347 - 28,547,722 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005329392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010001352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000031541   ⟹   ENSSTOP00000026176
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365561,160,385 - 1,170,843 (+)Ensembl
RefSeq Acc Id: XM_005329392   ⟹   XP_005329449
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244062929,569,711 - 9,576,535 (-)NCBI
SpeTri2.0NW_0049365561,161,359 - 1,167,283 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005329449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000026176.1
GenBank Protein KAG3266993 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005329449   ⟸   XM_005329392
- UniProtKB: A0A287CY26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000026176   ⟸   ENSSTOT00000031541
Protein Domains
Transcription factor CBF/NF-Y/archaeal histone


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000030120 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000031541.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro CBFA_NFYB_domain UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
NCBI Gene Pole4 ENTREZGENE
PANTHER DNA POLYMERASE EPSILON SUBUNIT 4 UniProtKB/TrEMBL
  HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED UniProtKB/TrEMBL
Pfam CBFD_NFYB_HMF UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A287CY26 ENTREZGENE, UniProtKB/TrEMBL