Arfgef3 (ARFGEF family member 3) - Rat Genome Database

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Gene: Arfgef3 (ARFGEF family member 3) Ictidomys tridecemlineatus
Analyze
Symbol: Arfgef3
Name: ARFGEF family member 3
RGD ID: 12462532
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN regulation of ARF protein signal transduction (inferred); ASSOCIATED WITH dystonia (ortholog); Familial Behcet-Like Autoinflammatory Syndrome (ortholog); Febrile Seizures (ortholog); FOUND IN Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: brefeldin A-inhibited guanine nucleotide-exchange protein 3; Kiaa1244
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946125,569,562 - 125,721,243 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365605,348,791 - 5,500,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365605,348,786 - 5,501,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Arfgef3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946125,569,562 - 125,721,243 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365605,348,791 - 5,500,874 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365605,348,786 - 5,501,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARFGEF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386138,161,939 - 138,344,663 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6138,161,939 - 138,344,663 (+)EnsemblGRCh38hg38GRCh38
GRCh376138,483,076 - 138,665,800 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366138,524,917 - 138,701,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 346138,569,923 - 138,701,629NCBI
Celera6139,223,168 - 139,405,937 (+)NCBICelera
Cytogenetic Map6q23.3-q24.1NCBI
HuRef6136,044,516 - 136,227,216 (+)NCBIHuRef
CHM1_16138,745,409 - 138,928,150 (+)NCBICHM1_1
T2T-CHM13v2.06139,350,430 - 139,533,149 (+)NCBIT2T-CHM13v2.0
Arfgef3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391018,463,759 - 18,619,506 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1018,457,587 - 18,619,697 (-)EnsemblGRCm39 Ensembl
GRCm381018,588,011 - 18,743,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1018,581,839 - 18,743,949 (-)EnsemblGRCm38mm10GRCm38
MGSCv371018,307,817 - 18,463,564 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361018,277,427 - 18,433,174 (-)NCBIMGSCv36mm8
Celera1018,494,647 - 18,649,063 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map107.79NCBI
Arfgef3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,058,574 - 15,223,742 (-)NCBIGRCr8
mRatBN7.2113,245,578 - 13,404,319 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,244,830 - 13,404,084 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0113,837,861 - 13,918,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl113,838,707 - 13,915,594 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0113,986,480 - 14,064,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0115,548,420 - 15,637,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4113,680,369 - 13,841,423 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1113,680,844 - 13,841,485 (-)NCBI
Celera111,698,155 - 11,856,654 (-)NCBICelera
Cytogenetic Map1p12NCBI
Arfgef3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543621,220,743 - 21,366,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543621,220,743 - 21,366,477 (-)NCBIChiLan1.0ChiLan1.0
ARFGEF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25158,119,095 - 158,306,557 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16156,016,706 - 156,204,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06135,916,799 - 136,100,287 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16140,010,547 - 140,187,173 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6140,010,542 - 140,179,197 (+)Ensemblpanpan1.1panPan2
ARFGEF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1130,482,375 - 30,658,706 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl130,527,870 - 30,652,027 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,361,691 - 31,537,808 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0130,646,268 - 30,822,469 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl130,646,228 - 30,818,792 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1130,524,950 - 30,701,101 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0130,406,541 - 30,583,150 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0130,715,619 - 30,891,829 (+)NCBIUU_Cfam_GSD_1.0
ARFGEF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,076,302 - 26,255,421 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,069,337 - 26,256,871 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,205,357 - 29,262,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARFGEF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11335,066,605 - 35,247,749 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1335,069,082 - 35,247,727 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660407,234,046 - 7,425,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arfgef3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475315,554,360 - 15,700,481 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475315,526,452 - 15,700,365 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000025052   ⟹   ENSSTOP00000021598
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365605,348,791 - 5,500,874 (+)Ensembl
RefSeq Acc Id: XM_005329807   ⟹   XP_005329864
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946125,569,709 - 125,721,006 (+)NCBI
SpeTri2.0NW_0049365605,348,786 - 5,501,233 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040283386   ⟹   XP_040139320
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946125,569,562 - 125,721,243 (+)NCBI
RefSeq Acc Id: XM_040283387   ⟹   XP_040139321
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946125,648,411 - 125,721,243 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005329864 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139320 (Get FASTA)   NCBI Sequence Viewer  
  XP_040139321 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000021598.2
GenBank Protein KAG3290350 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005329864   ⟸   XM_005329807
- Peptide Label: isoform X2
- UniProtKB: I3NB51 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139320   ⟸   XM_040283386
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040139321   ⟸   XM_040283387
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000021598   ⟸   ENSSTOT00000025052
Protein Domains
SEC7


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028835 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000025052.2 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  DCB_dom UniProtKB/TrEMBL
  Sec7/BIG1-like_C UniProtKB/TrEMBL
  Sec7_C UniProtKB/TrEMBL
  Sec7_dom UniProtKB/TrEMBL
NCBI Gene Arfgef3 ENTREZGENE
PANTHER BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 3 UniProtKB/TrEMBL
  GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
Pfam BIG2_C UniProtKB/TrEMBL
  DCB UniProtKB/TrEMBL
  DUF1981 UniProtKB/TrEMBL
SMART Sec7 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt I3NB51 ENTREZGENE, UniProtKB/TrEMBL