Osbp (oxysterol binding protein) - Rat Genome Database

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Gene: Osbp (oxysterol binding protein) Ictidomys tridecemlineatus
Analyze
Symbol: Osbp
Name: oxysterol binding protein
RGD ID: 12451470
Description: ENCODES a protein that exhibits lipid binding (inferred); phosphatidylinositol-4-phosphate binding (inferred); protein domain specific binding (inferred); INVOLVED IN positive regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); positive regulation of secretory granule organization (ortholog); positive regulation of tyrosine phosphorylation of STAT protein (ortholog); ASSOCIATED WITH colorectal cancer (ortholog); dengue hemorrhagic fever (ortholog); Dwarfism (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC101956774; oxysterol-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494713,004,370 - 13,035,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365813,118,192 - 3,149,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365813,118,198 - 3,148,882 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Osbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494713,004,370 - 13,035,064 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365813,118,192 - 3,149,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365813,118,198 - 3,148,882 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,574,398 - 59,615,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,574,398 - 59,615,774 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,341,871 - 59,383,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,098,447 - 59,140,193 (-)NCBINCBI36Build 36hg18NCBI36
Build 341159,098,446 - 59,140,193NCBI
Celera1156,704,609 - 56,746,356 (-)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1155,689,279 - 55,730,916 (-)NCBIHuRef
CHM1_11159,207,877 - 59,249,624 (-)NCBICHM1_1
T2T-CHM13v2.01159,525,317 - 59,566,697 (-)NCBIT2T-CHM13v2.0
Osbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,943,208 - 11,971,478 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,943,305 - 11,971,476 (+)EnsemblGRCm39 Ensembl
GRCm381911,965,844 - 11,994,114 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,965,941 - 11,994,112 (+)EnsemblGRCm38mm10GRCm38
MGSCv371912,040,334 - 12,068,604 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361912,025,792 - 12,061,163 (+)NCBIMGSCv36mm8
Celera1912,661,014 - 12,689,281 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map198.58NCBI
Osbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81218,313,455 - 218,343,263 (+)NCBIGRCr8
mRatBN7.21208,888,697 - 208,918,511 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1208,887,895 - 208,918,506 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,263,376 - 217,293,183 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01224,239,275 - 224,269,100 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,017,813 - 217,047,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01228,395,237 - 228,425,366 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1228,395,558 - 228,425,361 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01235,459,945 - 235,490,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,813,081 - 214,843,558 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,971,585 - 214,999,891 (+)NCBI
Celera1206,354,248 - 206,384,069 (+)NCBICelera
Cytogenetic Map1q43NCBI
Osbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555114,057,514 - 4,076,046 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555114,057,514 - 4,076,039 (-)NCBIChiLan1.0ChiLan1.0
OSBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2960,706,560 - 60,746,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11161,749,682 - 61,789,770 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,800,756 - 54,841,191 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,250,743 - 58,292,797 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,252,925 - 58,291,154 (-)Ensemblpanpan1.1panPan2
OSBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11837,159,511 - 37,191,720 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1837,159,576 - 37,189,731 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1836,807,234 - 36,841,694 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01837,798,279 - 37,832,754 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1837,798,294 - 37,832,754 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11837,388,157 - 37,422,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01836,964,263 - 36,998,700 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01837,593,776 - 37,628,258 (+)NCBIUU_Cfam_GSD_1.0
OSBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl211,876,324 - 11,911,656 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1211,876,294 - 11,911,660 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2211,349,981 - 11,385,515 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OSBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1114,009,735 - 14,053,232 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl114,010,020 - 14,051,605 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038111,337,416 - 111,379,527 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Osbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248641,176,173 - 1,198,217 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248641,176,619 - 1,199,905 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005331547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000027150   ⟹   ENSSTOP00000022373
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365813,118,192 - 3,149,005 (+)Ensembl
RefSeq Acc Id: XM_005331547   ⟹   XP_005331604
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494713,004,370 - 13,035,064 (+)NCBI
SpeTri2.0NW_0049365813,118,198 - 3,148,882 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005331604 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022373.2
GenBank Protein KAG3284967 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005331604   ⟸   XM_005331547
- UniProtKB: I3NDC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000022373   ⟸   ENSSTOT00000027150
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000024413 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000027150.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.40.160.120 UniProtKB/TrEMBL
InterPro OSBP_sf UniProtKB/TrEMBL
  Oxysterol-bd UniProtKB/TrEMBL
  Oxysterol-bd_CS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene Osbp ENTREZGENE
PANTHER OXYSTEROL-BINDING PROTEIN 1 UniProtKB/TrEMBL
  PTHR10972 UniProtKB/TrEMBL
Pfam Oxysterol_BP UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PROSITE OSBP UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF144000 UniProtKB/TrEMBL
UniProt I3NDC6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 Osbp  oxysterol binding protein  LOC101956774  oxysterol binding protein  Symbol and/or name change 5135510 APPROVED
2021-03-26 LOC101956774  oxysterol binding protein  Osbp  oxysterol binding protein  Symbol and/or name change 5135510 APPROVED