RGD Reference Report - Fetal asphyxia induces acute and persisting changes in the ceramide metabolism in rat brain. - Rat Genome Database

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Fetal asphyxia induces acute and persisting changes in the ceramide metabolism in rat brain.

Authors: Vlassaks, Evi  Mencarelli, Chiara  Nikiforou, Maria  Strackx, Eveline  Ferraz, Maria J  Aerts, Johannes M  De Baets, Marc H  Martinez-Martinez, Pilar  Gavilanes, Antonio W D 
Citation: Vlassaks E, etal., J Lipid Res. 2013 Jul;54(7):1825-33. doi: 10.1194/jlr.M034447. Epub 2013 Apr 26.
RGD ID: 156431056
Pubmed: PMID:23625371   (View Abstract at PubMed)
PMCID: PMC3679385   (View Article at PubMed Central)
DOI: DOI:10.1194/jlr.M034447   (Journal Full-text)

Fetal asphyctic preconditioning, induced by a brief episode of experimental hypoxia-ischemia, offers neuroprotection to a subsequent more severe asphyctic insult at birth. Extensive cell stress and apoptosis are important contributing factors of damage in the asphyctic neonatal brain. Because ceramide acts as a second messenger for multiple apoptotic stimuli, including hypoxia/ischemia, we sought to investigate the possible involvement of the ceramide pathway in endogenous neuroprotection induced by fetal asphyctic preconditioning. Global fetal asphyxia was induced in rats by clamping both uterine and ovarian vasculature for 30 min. Fetal asphyxia resulted in acute changes in brain ceramide/sphingomyelin metabolic enzymes, ceramide synthase 1, 2, and 5, acid sphingomyelinase, sphingosine-1-phosphate phosphatase, and the ceramide transporter. This observation correlated with an increase in neuronal apoptosis and in astrocyte number. After birth, ceramide and sphingomyelin levels remained high in fetal asphyxia brains, suggesting that a long-term regulation of the ceramide pathway may be involved in the mechanism of tolerance to a subsequent, otherwise lethal, asphyctic event.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CERS1HumanPerinatal Asphyxia  ISOCers1 (Rattus norvegicus) RGD 
CERT1HumanPerinatal Asphyxia  ISOCert1 (Rattus norvegicus) RGD 
Cers1RatPerinatal Asphyxia  IEP  RGD 
Cers1MousePerinatal Asphyxia  ISOCers1 (Rattus norvegicus) RGD 
Cert1RatPerinatal Asphyxia  IEP  RGD 
Cert1MousePerinatal Asphyxia  ISOCert1 (Rattus norvegicus) RGD 
OSBPHumanPerinatal Asphyxia  ISOOsbp (Rattus norvegicus) RGD 
OsbpRatPerinatal Asphyxia  IEP  RGD 
OsbpMousePerinatal Asphyxia  ISOOsbp (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cers1  (ceramide synthase 1)
Cert1  (ceramide transporter 1)
Osbp  (oxysterol binding protein)

Genes (Mus musculus)
Cers1  (ceramide synthase 1)
Cert1  (ceramide transporter 1)
Osbp  (oxysterol binding protein)

Genes (Homo sapiens)
CERS1  (ceramide synthase 1)
CERT1  (ceramide transporter 1)
OSBP  (oxysterol binding protein)


Additional Information