Ctu1 (cytosolic thiouridylase subunit 1)

Gene: Ctu1 (cytosolic thiouridylase subunit 1) Ictidomys tridecemlineatus

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Symbol:

Ctu1

Name:

cytosolic thiouridylase subunit 1

RGD ID:

12445606

Description:

ENCODES a protein that exhibits ATP binding (inferred); catalytic activity (inferred); nucleotidyltransferase activity (inferred); INVOLVED IN protein urmylation (inferred); tRNA processing (inferred); tRNA thio-modification (inferred); ASSOCIATED WITH Animal Disease Models (ortholog); Breast Neoplasms (ortholog); Neoplasm Invasiveness (ortholog); FOUND IN cytoplasm (inferred); cytosolic tRNA wobble base thiouridylase complex (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytoplasmic tRNA 2-thiolation protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	22,852,966 - 22,859,793 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936889	728,362 - 733,141 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936889	728,956 - 735,692 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Breast Neoplasms (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein urmylation (IEA)

tRNA processing (IEA)

tRNA thio-modification (IEA)

tRNA wobble position uridine thiolation (IEA)

tRNA wobble uridine modification (IEA)

Cellular Component

cytoplasm (IEA)

cytosolic tRNA wobble base thiouridylase complex (IEA)

mitochondrion (IEA)

Molecular Function

ATP binding (IEA)

catalytic activity (IEA)

nucleotidyltransferase activity (IEA)

protein binding (ISO)

transferase activity (IEA)

tRNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ctu1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	22,852,966 - 22,859,793 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936889	728,362 - 733,141 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936889	728,956 - 735,692 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTU1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	51,097,606 - 51,108,409 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	51,097,606 - 51,108,409 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	51,600,863 - 51,611,666 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	56,293,587 - 56,299,659 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	48,652,948 - 48,663,731 (-)	NCBI		Celera
Cytogenetic Map	19	q13.41	NCBI
HuRef	19	47,934,059 - 47,944,843 (-)	NCBI		HuRef
CHM1_1	19	51,602,851 - 51,613,631 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	54,186,212 - 54,197,016 (-)	NCBI		T2T-CHM13v2.0

Ctu1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	43,321,400 - 43,327,724 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	43,321,440 - 43,327,722 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	43,671,971 - 43,678,301 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	43,672,016 - 43,678,298 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	50,927,401 - 50,933,668 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	43,540,073 - 43,546,340 (+)	NCBI		MGSCv36	mm8
Celera	7	39,136,142 - 39,142,406 (+)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	28.26	NCBI

Ctu1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	103,251,983 - 103,257,778 (+)	NCBI		GRCr8
mRatBN7.2	1	94,115,431 - 94,121,224 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	94,115,420 - 94,121,221 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	99,500,862 - 99,506,654 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	107,973,522 - 107,979,314 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	101,256,902 - 101,262,693 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	99,599,608 - 99,605,412 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	99,599,620 - 99,605,412 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	100,668,356 - 100,674,148 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	94,083,641 - 94,089,433 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	94,163,849 - 94,166,542 (+)	NCBI
Celera	1	88,384,549 - 88,390,341 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

Ctu1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955558	959,819 - 960,369 (-)	NCBI	ChiLan1.0	ChiLan1.0

CTU1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	57,167,965 - 57,177,933 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	59,089,406 - 59,099,402 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	48,065,741 - 48,075,758 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	56,953,113 - 56,963,262 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

CTU1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	105,795,273 - 105,800,722 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	105,367,922 - 105,373,684 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	106,304,349 - 106,310,133 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	106,304,316 - 106,310,133 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	105,976,104 - 105,981,866 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	105,617,196 - 105,623,369 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	106,412,402 - 106,418,193 (+)	NCBI		UU_Cfam_GSD_1.0

CTU1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	55,738,216 - 55,745,743 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CTU1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	44,117,233 - 44,132,657 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	44,117,331 - 44,124,145 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	24,163,516 - 24,174,918 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ctu1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624832	3,433,809 - 3,438,847 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005341692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000015294 ⟹ ENSSTOP00000013703

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936889	728,362 - 733,141 (-)	Ensembl

RefSeq Acc Id:

XM_005341692 ⟹ XP_005341749

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	22,852,966 - 22,859,793 (-)	NCBI
SpeTri2.0	NW_004936889	728,956 - 735,692 (-)	NCBI

Sequence:

show sequence

TCCGCACCGGGCTGAGCGTGGTAGGCGCGCGGCACTTCCCGACGTGGCGTTCTGCACCGGAGAA
GCCGACTCCGCGATGCCCGCCCCAACGTGCGCCTCCTGCCACACGGCTCGGGCAAACCTCCGGC
GCCCGCGCTCAGGGCAGGCGCTGTGTGGTGCCTGCTTCTGCAATGCCTTCGAAGCCGAGGTGCT
GCACACGGTGCTCGCTGGCCGCCTGCTACCACGTGGCGCTGTGGTGGCTGTGGGTGCCTCGGGT
GGCAAGGACTCCACCGTGCTCGCGCATGTCCTGCGCGCACTGGCACCCCAGCTGGACATCTCAC
TGCACCTTGTGGCCGTGGATGAGGGCATCGGCGGCTACCGGGATGCGGCGCTGGCAGCTGTTAG
GCACCAGGCAGCGCGCTGGGAACTGCCACTCACTGTCGTGGCCTACGAAGACCTCTTTGGGGGC
TGGACAATGGATGCGGTGGCCCGCAGTACAGCTGGCTCTGGCCGCAGCCGCTCCTGCTGCACTT
TCTGCGGGGTCCTGCGTCGCCGAGCCCTGGAGGAAGGGGCACGCCTTGTGGGAGCCACGCACAT
CGTGACAGGTCACAACGCGGACGACATGGCAGAGACGGTGCTCATGAACTTCCTGAGGGGTGAC
GCGGGGCGGCTGGCCCGGGGCGGCGGGCTGGGCTCCCCGGGCGAGGGGGGCGCGTTGCCGCGCT
GCCGGCCACTGCAGCTGGCGTCGCAGAAGGAGGTGGTGCTGTACGCGCACTTCCGCCGCCTGCA
CTACTTCTCTGAGGAGTGCGTCTACGCGCCCGAGGCCTTCCGCGGCCACGCTCGCGACCTGCTC
AAGCGCCTGGAGGCGGCGCGGCCGTCGGCTGTGCTGGACCTGGTGCACTCTGCCGAGCGCCTGG
CGCTGGCCCCGACCGCGAGGCCCCCGCGCCCCGGCGCCTGCTCCCGCTGTGGGGCGCTGGCCAG
CCGCGCGCTCTGCCAGGCCTGCGCGCTCCTGGACGGCCTGAACCGCGGCCTGCCCCGCCTGGCC
ATTGGCAAAGGTCGCCGCGAGCTGGAGCTGGAAGAGGCACCACGGCGGAGCGTCCCCGCCGCCG
ATGCCCTCACGGCCTTCTAGCGGCTCCAGGTCCCTCTGGGACCTGGCACCCGGGCGGGAGGGGC
TCCCTGTAAATAACACTGTGAATAAACTCAGAGCTGTCTGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005341749	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013703.2
GenBank Protein	KAG3256613	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005341749 ⟸ XM_005341692

- UniProtKB:

I3MPI2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAPTCASCHTARANLRRPRSGQALCGACFCNAFEAEVLHTVLAGRLLPRGAVVAVGASGGKDS
TVLAHVLRALAPQLDISLHLVAVDEGIGGYRDAALAAVRHQAARWELPLTVVAYEDLFGGWTMD
AVARSTAGSGRSRSCCTFCGVLRRRALEEGARLVGATHIVTGHNADDMAETVLMNFLRGDAGRL
ARGGGLGSPGEGGALPRCRPLQLASQKEVVLYAHFRRLHYFSEECVYAPEAFRGHARDLLKRLE
AARPSAVLDLVHSAERLALAPTARPPRPGACSRCGALASRALCQACALLDGLNRGLPRLAIGKG
RRELELEEAPRRSVPAADALTAF

hide sequence

RefSeq Acc Id:

ENSSTOP00000013703 ⟸ ENSSTOT00000015294

Protein Domains

Cytoplasmic tRNA 2-thiolation protein 1 C-terminal tRNA(Ile)-lysidine/2-thiocytidine synthase N-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000015294	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000015294.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.620	UniProtKB/TrEMBL
InterPro	CTU1_C	UniProtKB/TrEMBL
	Ncs6/Tuc1/Ctu1	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
	TilS/TtcA_N	UniProtKB/TrEMBL
	tRNA_thiolation_TtcA_Ctu1	UniProtKB/TrEMBL
NCBI Gene	Ctu1	ENTREZGENE
PANTHER	ATPASES OF THE PP SUPERFAMILY-RELATED	UniProtKB/TrEMBL
	PTHR11807:SF12	UniProtKB/TrEMBL
Pfam	ATP_bind_3	UniProtKB/TrEMBL
	zn-ribbon_14	UniProtKB/TrEMBL
PIRSF	ATPase_YdaO	UniProtKB/TrEMBL
Superfamily-SCOP	Adenine nucleotide alpha hydrolases-like	UniProtKB/TrEMBL
UniProt	I3MPI2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD