Ruvbl1 (RuvB like AAA ATPase 1) - Rat Genome Database

Name: Ruvbl1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Ruvbl1 (RuvB like AAA ATPase 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Ruvbl1

Name:

RuvB like AAA ATPase 1

RGD ID:

12438659

Description:

ENCODES a protein that exhibits 3'-5' DNA helicase activity (ortholog); INVOLVED IN positive regulation of plasminogen activation (ortholog); positive regulation of telomerase RNA localization to Cajal body (ortholog); regulation of fibroblast apoptotic process (ortholog); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; ASSOCIATED WITH alkaptonuria (ortholog); Autosomal Dominant Tubulointerstitial Kidney Disease 5 (ortholog); Common Variable Immunodeficiency 15 (ortholog); FOUND IN Ino80 complex (ortholog); NuA4 histone acetyltransferase complex (ortholog); nuclear matrix (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

RuvB-like 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RUVBL1 (RuvB like AAA ATPase 1)	NCBI	Ortholog
Mus musculus (house mouse):	Ruvbl1 (RuvB-like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ruvbl1 (RuvB-like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ruvbl1 (RuvB like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RUVBL1 (RuvB like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RUVBL1 (RuvB like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RUVBL1 (RuvB like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RUVBL1 (RuvB like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ruvbl1 (RuvB like AAA ATPase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	20,517,860 - 20,530,840 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936798	559,778 - 572,506 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936798	559,706 - 572,710 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alkaptonuria (ISO)

Autosomal Dominant Tubulointerstitial Kidney Disease 5 (ISO)

Common Variable Immunodeficiency 15 (ISO)

genetic disease (ISO)

immunodeficiency 21 (ISO)

polycystic liver disease (ISO)

Polycystic Liver Disease 1 (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

box C/D snoRNP assembly (IEA)

chromatin remodeling (IEA)

chromosome organization (IEA)

DNA duplex unwinding (IEA)

DNA recombination (IEA)

DNA repair (IEA)

positive regulation of canonical Wnt signaling pathway (IEA)

positive regulation of DNA repair (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of double-strand break repair via homologous recombination (IEA)

positive regulation of plasminogen activation (ISO)

positive regulation of telomerase RNA localization to Cajal body (ISO)

positive regulation of telomere maintenance in response to DNA damage (IEA)

regulation of cell cycle (IEA)

regulation of chromosome organization (IEA)

regulation of DNA repair (IEA)

regulation of DNA replication (IEA)

regulation of DNA strand elongation (IEA)

regulation of embryonic development (IEA)

regulation of fibroblast apoptotic process (ISO)

regulation of transcription by RNA polymerase II (IEA)

telomere maintenance (IEA)

Cellular Component

cytosol (IEA)

dynein axonemal particle (IEA)

Ino80 complex (IEA,ISO)

MLL1 complex (IEA)

NuA4 histone acetyltransferase complex (IEA,ISO)

nuclear matrix (ISO)

nucleoplasm (IEA)

nucleosome (IEA,ISO)

nucleus (IEA)

protein folding chaperone complex (IEA,ISO)

protein-containing complex (ISO)

R2TP complex (IEA,ISO)

ribonucleoprotein complex (IEA)

RPAP3/R2TP/prefoldin-like complex (IEA,ISO)

Swr1 complex (IEA)

Molecular Function

3'-5' DNA helicase activity (ISO)

ADP binding (IEA)

ATP binding (IEA)

ATP hydrolysis activity (IEA)

ATP-dependent activity, acting on DNA (IEA)

ATPase binding (IEA)

DNA helicase activity (IEA)

helicase activity (IEA)

hydrolase activity (IEA)

protein binding (ISO)

TBP-class protein binding (IEA)

TFIID-class transcription factor complex binding (IEA)

transcription coactivator activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

INO80 family mediated chromatin remodeling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ruvbl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	20,517,860 - 20,530,840 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936798	559,778 - 572,506 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936798	559,706 - 572,710 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RUVBL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	128,064,785 - 128,153,914 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	128,064,778 - 128,153,914 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	127,783,628 - 127,872,757 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	129,282,493 - 129,325,332 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	129,282,500 - 129,325,340	NCBI
Celera	3	126,230,848 - 126,272,604 (-)	NCBI		Celera
Cytogenetic Map	3	q21.3	NCBI
HuRef	3	125,180,247 - 125,223,118 (-)	NCBI		HuRef
CHM1_1	3	127,763,012 - 127,805,897 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	130,799,360 - 130,895,553 (-)	NCBI		T2T-CHM13v2.0

Ruvbl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	88,442,391 - 88,474,548 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	88,442,391 - 88,474,554 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	88,465,409 - 88,497,566 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	88,465,409 - 88,497,572 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	88,415,417 - 88,447,560 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	88,431,107 - 88,463,207 (+)	NCBI		MGSCv36	mm8
Celera	6	90,403,044 - 90,439,348 (+)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	39.51	NCBI

Ruvbl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	122,489,754 - 122,524,666 (+)	NCBI		GRCr8
mRatBN7.2	4	120,932,486 - 120,967,400 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	120,932,417 - 121,029,384 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	126,403,089 - 126,438,005 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	122,177,844 - 122,212,760 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	120,802,088 - 120,837,004 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	120,411,917 - 120,447,458 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	120,411,991 - 120,447,455 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	185,651,851 - 185,687,385 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	122,556,857 - 122,591,769 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	122,801,337 - 122,836,249 (+)	NCBI
Celera	4	109,888,321 - 109,923,233 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Ruvbl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	15,598,465 - 15,633,713 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	15,598,465 - 15,632,290 (+)	NCBI	ChiLan1.0	ChiLan1.0

RUVBL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	125,999,065 - 126,078,403 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	126,003,787 - 126,083,009 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	125,120,524 - 125,200,859 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	132,486,229 - 132,528,925 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	132,486,229 - 132,528,918 (-)	Ensembl	panpan1.1		panPan2

RUVBL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	2,095,807 - 2,137,528 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	2,095,786 - 2,137,579 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	2,132,722 - 2,174,676 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	2,117,012 - 2,159,070 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	2,117,017 - 2,159,053 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	1,837,866 - 1,879,813 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	2,164,688 - 2,206,489 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	2,124,982 - 2,166,796 (-)	NCBI		UU_Cfam_GSD_1.0

RUVBL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	72,200,511 - 72,248,582 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	72,196,219 - 72,246,514 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RUVBL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	52,887,374 - 52,967,728 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	52,924,819 - 52,967,830 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	113,388,160 - 113,468,540 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ruvbl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624961	427,836 - 460,887 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021720303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040291577	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000004675 ⟹ ENSSTOP00000004196

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936798	559,778 - 572,506 (+)	Ensembl

RefSeq Acc Id:

XM_040291577 ⟹ XP_040147511

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404942	20,517,860 - 20,530,840 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_040147511	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004196.3
GenBank Protein	KAG3295204	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_040147511 ⟸ XM_040291577

RefSeq Acc Id:

ENSSTOP00000004196 ⟸ ENSSTOT00000004675

Protein Domains

AAA+ ATPase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000004659	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000004675.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	NA-bd_OB-fold	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RuvB-like	UniProtKB/TrEMBL
	RuvB-like_C	UniProtKB/TrEMBL
	TIP49_P-loop	UniProtKB/TrEMBL
NCBI Gene	Ruvbl1	ENTREZGENE
PANTHER	PTHR11093	UniProtKB/TrEMBL
	PTHR11093:SF6	UniProtKB/TrEMBL
Pfam	TIP49	UniProtKB/TrEMBL
	TIP49_C	UniProtKB/TrEMBL
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50249	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	I3M4N9_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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