MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) - Rat Genome Database

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Gene: MFNG (MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase) Canis lupus familiaris
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Symbol: MFNG
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGD ID: 12266566
Description: ENCODES a protein that exhibits glycosyltransferase activity (inferred); metal ion binding (inferred); O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity (inferred); INVOLVED IN blastocyst formation (ortholog); positive regulation of Notch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); myoclonic dystonia 26 (ortholog); FOUND IN Golgi apparatus (inferred); Golgi membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-1,3-N-acetylglucosaminyltransferase manic fringe
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,082,616 - 27,098,994 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,082,789 - 27,098,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,037,155 - 27,053,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,874,455 - 27,890,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,846,464 - 27,890,680 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,596,327 - 27,612,563 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,904,972 - 27,921,207 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,082,732 - 28,098,966 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MFNG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,082,616 - 27,098,994 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,082,789 - 27,098,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,037,155 - 27,053,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,874,455 - 27,890,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,846,464 - 27,890,680 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,596,327 - 27,612,563 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,904,972 - 27,921,207 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,082,732 - 28,098,966 (+)NCBIUU_Cfam_GSD_1.0
MFNG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382237,469,063 - 37,486,384 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2237,469,063 - 37,486,393 (-)EnsemblGRCh38hg38GRCh38
GRCh372237,865,101 - 37,882,422 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,195,049 - 36,212,331 (-)NCBINCBI36Build 36hg18NCBI36
Build 342236,189,602 - 36,206,885NCBI
Celera2221,665,904 - 21,683,281 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2220,831,325 - 20,848,704 (-)NCBIHuRef
CHM1_12237,823,899 - 37,841,275 (-)NCBICHM1_1
T2T-CHM13v2.02237,929,523 - 37,947,248 (-)NCBIT2T-CHM13v2.0
Mfng
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391578,640,082 - 78,657,678 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1578,640,082 - 78,657,675 (-)EnsemblGRCm39 Ensembl
GRCm381578,755,882 - 78,773,516 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1578,755,882 - 78,773,475 (-)EnsemblGRCm38mm10GRCm38
MGSCv371578,586,313 - 78,603,875 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361578,583,138 - 78,600,700 (-)NCBIMGSCv36mm8
Celera1580,221,888 - 80,237,486 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.69NCBI
Mfng
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,191,288 - 112,209,129 (-)NCBIGRCr8
mRatBN7.27110,310,810 - 110,328,653 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,310,812 - 110,328,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,061,715 - 112,079,333 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,285,241 - 114,302,863 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,252,907 - 114,270,641 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,978,981 - 119,996,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,978,983 - 119,996,824 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,970,579 - 119,988,416 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47116,717,405 - 116,735,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17116,751,634 - 116,769,510 (-)NCBI
Celera7106,646,792 - 106,664,572 (-)NCBICelera
Cytogenetic Map7q34NCBI
Mfng
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,902,707 - 23,917,542 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,901,987 - 23,917,720 (-)NCBIChiLan1.0ChiLan1.0
MFNG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,328,155 - 47,349,696 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,016,754 - 50,038,296 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,385,664 - 18,407,056 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,218,403 - 36,236,402 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,218,403 - 36,239,804 (-)Ensemblpanpan1.1panPan2
Mfng
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,536,906 - 10,551,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,547,282 - 3,562,022 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,547,345 - 3,561,940 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFNG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl510,319,816 - 10,344,832 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1510,319,821 - 10,334,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,856,078 - 7,869,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MFNG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,177,108 - 20,195,406 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1920,176,878 - 20,194,915 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045105,630,340 - 105,651,186 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfng
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475210,394,008 - 10,412,412 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475210,394,025 - 10,411,265 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MFNG
130 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 6 5 6
Low 5 3 22 6 6 6 6 12 4 5
Below cutoff 4

Sequence


RefSeq Acc Id: ENSCAFT00000002342   ⟹   ENSCAFP00000002164
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1027,082,789 - 27,098,617 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012488   ⟹   ENSCAFP00845009757
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,846,464 - 27,890,680 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012509   ⟹   ENSCAFP00845009772
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,846,464 - 27,889,830 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012549   ⟹   ENSCAFP00845009803
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,874,476 - 27,890,674 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845012575   ⟹   ENSCAFP00845009820
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1027,874,682 - 27,889,830 (+)Ensembl
RefSeq Acc Id: XM_038488691   ⟹   XP_038344619
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11027,596,327 - 27,612,563 (+)NCBI
RefSeq Acc Id: XM_038550652   ⟹   XP_038406580
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01028,082,732 - 28,098,966 (+)NCBI
RefSeq Acc Id: XM_038614587   ⟹   XP_038470515
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01027,904,972 - 27,921,207 (+)NCBI
RefSeq Acc Id: XM_038679947   ⟹   XP_038535875
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01027,874,455 - 27,890,695 (+)NCBI
RefSeq Acc Id: XM_847776   ⟹   XP_852869
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11027,082,616 - 27,098,994 (+)NCBI
Dog10K_Boxer_Tasha1027,037,155 - 27,053,393 (+)NCBI
Sequence:
RefSeq Acc Id: XP_852869   ⟸   XM_847776
- UniProtKB: A0A8C0JRZ8 (UniProtKB/TrEMBL),   A0A8I3NG67 (UniProtKB/TrEMBL),   A0A8P0PM89 (UniProtKB/TrEMBL),   A0A8C0MWH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000002164   ⟸   ENSCAFT00000002342
RefSeq Acc Id: XP_038344619   ⟸   XM_038488691
RefSeq Acc Id: XP_038470515   ⟸   XM_038614587
RefSeq Acc Id: XP_038535875   ⟸   XM_038679947
- UniProtKB: A0A8C0JRZ8 (UniProtKB/TrEMBL),   A0A8I3NG67 (UniProtKB/TrEMBL),   A0A8P0PM89 (UniProtKB/TrEMBL),   A0A8C0MWH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406580   ⟸   XM_038550652
- UniProtKB: A0A8C0JRZ8 (UniProtKB/TrEMBL),   A0A8C0MWH5 (UniProtKB/TrEMBL),   A0A8I3NG67 (UniProtKB/TrEMBL),   A0A8P0PM89 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009820   ⟸   ENSCAFT00845012575
RefSeq Acc Id: ENSCAFP00845009803   ⟸   ENSCAFT00845012549
RefSeq Acc Id: ENSCAFP00845009757   ⟸   ENSCAFT00845012488
RefSeq Acc Id: ENSCAFP00845009772   ⟸   ENSCAFT00845012509

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001503 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009759 UniProtKB/TrEMBL
  ENSCAFG00040009793 UniProtKB/TrEMBL
  ENSCAFG00845007032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000002342.5 UniProtKB/TrEMBL
  ENSCAFT00000098281.1 UniProtKB/TrEMBL
  ENSCAFT00000099095.1 UniProtKB/TrEMBL
  ENSCAFT00000106062.1 UniProtKB/TrEMBL
  ENSCAFT00030018066.1 UniProtKB/TrEMBL
  ENSCAFT00040018259.1 UniProtKB/TrEMBL
  ENSCAFT00040018314.1 UniProtKB/TrEMBL
  ENSCAFT00845012488 ENTREZGENE
  ENSCAFT00845012488.1 UniProtKB/TrEMBL
  ENSCAFT00845012509.1 UniProtKB/TrEMBL
  ENSCAFT00845012549.1 UniProtKB/TrEMBL
  ENSCAFT00845012575.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.550.50 UniProtKB/TrEMBL
InterPro Fringe UniProtKB/TrEMBL
  Fringe-like UniProtKB/TrEMBL
KEGG Report cfa:610303 UniProtKB/TrEMBL
NCBI Gene MFNG ENTREZGENE
PANTHER BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE UniProtKB/TrEMBL
  FRINGE-RELATED UniProtKB/TrEMBL
Pfam Fringe UniProtKB/TrEMBL
PIRSF B-acetylgalactosaminyltfrase UniProtKB/TrEMBL
UniProt A0A8C0JRZ8 ENTREZGENE
  A0A8C0MWH5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S4U2_CANLF UniProtKB/TrEMBL
  A0A8C0YTI8_CANLF UniProtKB/TrEMBL
  A0A8I3N0Q7_CANLF UniProtKB/TrEMBL
  A0A8I3N4V9_CANLF UniProtKB/TrEMBL
  A0A8I3NG67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RV56_CANLF UniProtKB/TrEMBL
  A0A8P0PM89 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0S7P8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43194 ENTREZGENE