ZSWIM2 (zinc finger SWIM-type containing 2) - Rat Genome Database

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Gene: ZSWIM2 (zinc finger SWIM-type containing 2) Canis lupus familiaris
Analyze
Symbol: ZSWIM2
Name: zinc finger SWIM-type containing 2
RGD ID: 12263332
Description: ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase ZSWIM2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,989,780 - 29,023,128 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,989,212 - 29,022,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,888,712 - 28,919,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03629,216,604 - 29,246,962 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3629,216,603 - 29,248,654 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13629,273,320 - 29,304,097 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03629,208,762 - 29,239,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03629,376,285 - 29,407,166 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ZSWIM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13628,989,780 - 29,023,128 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3628,989,212 - 29,022,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3628,888,712 - 28,919,697 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03629,216,604 - 29,246,962 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3629,216,603 - 29,248,654 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13629,273,320 - 29,304,097 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03629,208,762 - 29,239,789 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03629,376,285 - 29,407,166 (-)NCBIUU_Cfam_GSD_1.0
ZSWIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382186,827,475 - 186,849,170 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2186,827,475 - 186,849,208 (-)EnsemblGRCh38hg38GRCh38
GRCh372187,692,202 - 187,713,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362187,400,452 - 187,422,142 (-)NCBINCBI36Build 36hg18NCBI36
Build 342187,518,067 - 187,539,403NCBI
Celera2181,287,838 - 181,310,094 (-)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2179,552,221 - 179,573,906 (-)NCBIHuRef
CHM1_12187,698,209 - 187,719,897 (-)NCBICHM1_1
T2T-CHM13v2.02187,316,754 - 187,338,450 (-)NCBIT2T-CHM13v2.0
Zswim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39283,745,414 - 83,771,596 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl283,745,423 - 83,771,572 (-)EnsemblGRCm39 Ensembl
GRCm38283,915,079 - 83,941,226 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl283,915,079 - 83,941,228 (-)EnsemblGRCm38mm10GRCm38
MGSCv37283,755,236 - 83,781,383 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36283,715,918 - 83,742,065 (-)NCBIMGSCv36mm8
Celera285,573,761 - 85,599,958 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.33NCBI
Zswim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8389,401,887 - 89,422,308 (-)NCBIGRCr8
mRatBN7.2368,993,422 - 69,015,441 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl368,995,027 - 69,015,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx372,383,774 - 72,404,276 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0380,982,424 - 81,002,926 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0378,723,407 - 78,743,872 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0371,274,341 - 71,295,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,274,337 - 71,295,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0377,799,741 - 77,821,020 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,101,242 - 67,121,620 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1366,997,614 - 67,017,992 (-)NCBI
Celera368,365,685 - 68,386,070 (-)NCBICelera
Cytogenetic Map3q24NCBI
Zswim2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540311,479,808 - 11,495,577 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540311,478,682 - 11,494,725 (+)NCBIChiLan1.0ChiLan1.0
ZSWIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21389,505,429 - 89,533,071 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B89,520,409 - 89,548,051 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B74,120,669 - 74,142,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B191,921,210 - 191,942,554 (-)NCBIpanpan1.1PanPan1.1panPan2
Zswim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303146,187,316 - 146,203,819 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650610,634,364 - 10,650,469 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650610,634,364 - 10,650,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZSWIM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1591,840,944 - 91,864,332 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11591,840,694 - 91,865,227 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215101,850,741 - 101,872,225 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZSWIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11072,368,406 - 72,391,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1072,368,927 - 72,390,417 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040127,111,072 - 127,133,399 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zswim2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248993,107,902 - 3,129,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248993,107,362 - 3,129,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZSWIM2
598 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8
Low
Below cutoff 5 3 17 3 5 3 6 3 12 8 6

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005640386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014110691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014110692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022414797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038446754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038463240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038521371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038584524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038648941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000023376   ⟹   ENSCAFP00000021707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3628,989,212 - 29,019,884 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000062257   ⟹   ENSCAFP00000056273
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3628,989,212 - 29,022,057 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032835   ⟹   ENSCAFP00845025700
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3629,216,603 - 29,248,654 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845032941   ⟹   ENSCAFP00845025774
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3629,216,603 - 29,247,249 (-)Ensembl
RefSeq Acc Id: XM_038446754   ⟹   XP_038302682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03629,216,604 - 29,246,962 (-)NCBI
RefSeq Acc Id: XM_038463240   ⟹   XP_038319168
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3628,888,712 - 28,919,697 (-)NCBI
RefSeq Acc Id: XM_038521371   ⟹   XP_038377299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13629,273,320 - 29,304,097 (-)NCBI
RefSeq Acc Id: XM_038584524   ⟹   XP_038440452
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03629,376,285 - 29,407,166 (-)NCBI
RefSeq Acc Id: XM_038648941   ⟹   XP_038504869
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03629,208,762 - 29,239,789 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000056273   ⟸   ENSCAFT00000062257
RefSeq Acc Id: ENSCAFP00000021707   ⟸   ENSCAFT00000023376
RefSeq Acc Id: XP_038377299   ⟸   XM_038521371
RefSeq Acc Id: XP_038504869   ⟸   XM_038648941
RefSeq Acc Id: XP_038302682   ⟸   XM_038446754
- UniProtKB: A0A8C0S3C9 (UniProtKB/TrEMBL),   A0A8P0PMI3 (UniProtKB/TrEMBL),   A0A8C0N171 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038319168   ⟸   XM_038463240
- UniProtKB: A0A8C0S3C9 (UniProtKB/TrEMBL),   A0A8P0PMI3 (UniProtKB/TrEMBL),   A0A8C0N171 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440452   ⟸   XM_038584524
- UniProtKB: A0A8C0N171 (UniProtKB/TrEMBL),   A0A8C0S3C9 (UniProtKB/TrEMBL),   A0A8P0PMI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845025774   ⟸   ENSCAFT00845032941
RefSeq Acc Id: ENSCAFP00845025700   ⟸   ENSCAFT00845032835
Protein Domains
RING-type   SWIM-type   ZZ-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014719 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030010874 UniProtKB/TrEMBL
  ENSCAFG00040009405 UniProtKB/TrEMBL
  ENSCAFG00845018547 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023376.4 UniProtKB/TrEMBL
  ENSCAFT00000062257.2 UniProtKB/TrEMBL
  ENSCAFT00000105080.1 UniProtKB/TrEMBL
  ENSCAFT00030020148.1 UniProtKB/TrEMBL
  ENSCAFT00040017437.1 UniProtKB/TrEMBL
  ENSCAFT00040017502.1 UniProtKB/TrEMBL
  ENSCAFT00040017601.1 UniProtKB/TrEMBL
  ENSCAFT00845032835 ENTREZGENE
  ENSCAFT00845032835.1 UniProtKB/TrEMBL
  ENSCAFT00845032941.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  3.30.60.90 UniProtKB/TrEMBL
InterPro Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_SWIM UniProtKB/TrEMBL
  Znf_ZZ UniProtKB/TrEMBL
  Znf_ZZ_sf UniProtKB/TrEMBL
  Zswim2 UniProtKB/TrEMBL
NCBI Gene ZSWIM2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2 UniProtKB/TrEMBL
  PTHR21540 UniProtKB/TrEMBL
Pfam PF00569 UniProtKB/TrEMBL
  SWIM UniProtKB/TrEMBL
  zf-RING_2 UniProtKB/TrEMBL
PROSITE ZF_RING_2 UniProtKB/TrEMBL
  ZF_SWIM UniProtKB/TrEMBL
  ZF_ZZ_1 UniProtKB/TrEMBL
  ZF_ZZ_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8C0N171 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S381_CANLF UniProtKB/TrEMBL
  A0A8C0S3C9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0YSR8_CANLF UniProtKB/TrEMBL
  A0A8I3NWX6_CANLF UniProtKB/TrEMBL
  A0A8I3P0Y5_CANLF UniProtKB/TrEMBL
  A0A8P0PMI3 ENTREZGENE
UniProt Secondary A0A8P0PMI3 UniProtKB/TrEMBL
VGNC ID VGNC:48855 ENTREZGENE