HSPB8 (heat shock protein family B (small) member 8) - Rat Genome Database

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Gene: HSPB8 (heat shock protein family B (small) member 8) Canis lupus familiaris
Analyze
Symbol: HSPB8
Name: heat shock protein family B (small) member 8
RGD ID: 12237880
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN cellular response to unfolded protein (inferred); positive regulation of aggrephagy (inferred); ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 2 (ortholog); Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease axonal type 2L (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: H11 kinase; heat shock 27kDa protein 8; heat shock protein beta-8; protein kinase H11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12615,337,718 - 15,349,993 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2615,336,864 - 15,355,757 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2615,343,116 - 15,355,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02615,606,043 - 15,618,322 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2615,605,664 - 15,625,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12615,575,862 - 15,588,132 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02615,643,221 - 15,655,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02615,685,151 - 15,697,445 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISS)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA,ISS)
protein folding chaperone complex  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
HSPB8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12615,337,718 - 15,349,993 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2615,336,864 - 15,355,757 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2615,343,116 - 15,355,393 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02615,606,043 - 15,618,322 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2615,605,664 - 15,625,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12615,575,862 - 15,588,132 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02615,643,221 - 15,655,514 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02615,685,151 - 15,697,445 (+)NCBIUU_Cfam_GSD_1.0
HSPB8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812119,178,931 - 119,194,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12119,171,555 - 119,224,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3712119,616,736 - 119,632,551 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612118,100,978 - 118,116,934 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412118,079,314 - 118,095,270NCBI
Celera12119,249,740 - 119,265,695 (+)NCBICelera
Cytogenetic Map12q24.23NCBI
HuRef12116,624,758 - 116,640,724 (+)NCBIHuRef
CHM1_112119,584,428 - 119,600,385 (+)NCBICHM1_1
T2T-CHM13v2.012119,166,359 - 119,182,179 (+)NCBIT2T-CHM13v2.0
Hspb8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395116,546,550 - 116,560,923 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5116,546,550 - 116,560,923 (-)EnsemblGRCm39 Ensembl
GRCm385116,408,491 - 116,422,864 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5116,408,491 - 116,422,864 (-)EnsemblGRCm38mm10GRCm38
MGSCv375116,858,504 - 116,872,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365116,669,494 - 116,683,863 (-)NCBIMGSCv36mm8
Celera5113,505,586 - 113,520,087 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.41NCBI
Hspb8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81245,835,899 - 45,866,449 (+)NCBIGRCr8
mRatBN7.21240,176,405 - 40,205,002 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,176,532 - 40,191,185 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1241,351,855 - 41,366,486 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,965,698 - 41,980,331 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01241,026,095 - 41,040,728 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01245,905,371 - 45,920,014 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1245,905,371 - 45,920,013 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01247,717,762 - 47,731,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,407,166 - 41,421,565 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,270,553 - 41,284,952 (+)NCBI
Celera1241,813,553 - 41,828,157 (+)NCBICelera
Cytogenetic Map12q16NCBI
Hspb8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545512,290,587 - 12,304,656 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545512,290,884 - 12,304,588 (-)NCBIChiLan1.0ChiLan1.0
HSPB8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210127,244,376 - 127,260,703 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112127,240,755 - 127,257,082 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012116,758,785 - 116,774,883 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112120,136,986 - 120,153,102 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12120,136,986 - 120,153,102 (+)Ensemblpanpan1.1panPan2
Hspb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118146,997,711 - 147,017,378 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366681,496,600 - 1,505,650 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPB8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1433,626,120 - 33,640,792 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11433,626,125 - 33,639,824 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21435,688,321 - 35,701,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSPB8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111114,522,236 - 114,540,186 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11114,522,248 - 114,540,477 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037130,563,295 - 130,581,391 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspb8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474714,383,421 - 14,397,528 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474714,383,600 - 14,397,440 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HSPB8
174 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 2 2 3 1
Medium 5 3 16 6 6 4 12 7 5
Low 6 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000049861   ⟹   ENSCAFP00000041782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2615,336,864 - 15,350,402 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000064424   ⟹   ENSCAFP00000066603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2615,336,864 - 15,355,757 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845050898   ⟹   ENSCAFP00845039903
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2615,605,664 - 15,625,601 (+)Ensembl
RefSeq Acc Id: NM_001003029   ⟹   NP_001003029
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12615,337,718 - 15,349,993 (+)NCBI
Dog10K_Boxer_Tasha2615,343,116 - 15,355,393 (+)NCBI
ROS_Cfam_1.02615,606,043 - 15,618,322 (+)NCBI
UMICH_Zoey_3.12615,575,862 - 15,588,132 (+)NCBI
UNSW_CanFamBas_1.02615,643,221 - 15,655,514 (+)NCBI
UU_Cfam_GSD_1.02615,685,151 - 15,697,445 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003029 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM90297 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000066603.2
  ENSCAFP00845039903.1
GenBank Protein Q8MJ36 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001003029   ⟸   NM_001003029
- UniProtKB: Q8MJ36 (UniProtKB/Swiss-Prot),   A0A8I3PXI8 (UniProtKB/TrEMBL),   A0A8P0PF55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000066603   ⟸   ENSCAFT00000064424
RefSeq Acc Id: ENSCAFP00000041782   ⟸   ENSCAFT00000049861
RefSeq Acc Id: ENSCAFP00845039903   ⟸   ENSCAFT00845050898
Protein Domains
sHSP

Promoters
RGD ID:13687920
Promoter ID:EPDNEW_C5989
Type:single initiation site
Name:HSPB8_1
Description:heat shock protein beta-8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12615,337,339 - 15,337,399EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030537 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845028809 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000064424.2 UniProtKB/TrEMBL
  ENSCAFT00845050898.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-crystallin/Hsp20_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-crystallin/sHSP_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP20-like_chaperone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSPB8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HspB8_ACD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:403553 UniProtKB/Swiss-Prot
NCBI Gene HSPB8 ENTREZGENE
PANTHER HEAT SHOCK PROTEIN BETA-8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46906 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ACRYSTALLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SHSP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I3PXI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PF55 ENTREZGENE, UniProtKB/TrEMBL
  HSPB8_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:52935 ENTREZGENE