SULT1C4 (sulfotransferase family 1C member 4)

Gene: SULT1C4 (sulfotransferase family 1C member 4) Canis lupus familiaris

Analyze

Symbol:

SULT1C4

Name:

sulfotransferase family 1C member 4

RGD ID:

12224788

Description:

ENCODES a protein that exhibits aryl sulfotransferase activity (inferred); sulfotransferase activity (inferred); transferase activity (inferred); INVOLVED IN 3'-phosphoadenosine 5'-phosphosulfate metabolic process (inferred); doxorubicin metabolic process (inferred); ethanol catabolic process (inferred); ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 7 (ortholog); ectodermal dysplasia 10A (ortholog); ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3 (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sulfotransferase 1C4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	35,494,614 - 35,504,162 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	35,495,727 - 35,504,125 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	35,417,189 - 35,426,790 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	36,347,852 - 36,357,542 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	36,347,858 - 36,357,539 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	36,076,446 - 36,086,062 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	36,364,428 - 36,374,052 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	36,552,740 - 36,562,343 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant distal hereditary motor neuronopathy 7 (ISO)

ectodermal dysplasia 10A (ISO)

ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

3'-phosphoadenosine 5'-phosphosulfate metabolic process (IEA)

doxorubicin metabolic process (IEA)

ethanol catabolic process (IEA)

flavonoid metabolic process (IEA)

sulfation (IEA)

xenobiotic metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

Molecular Function

aryl sulfotransferase activity (IEA)

sulfotransferase activity (IEA)

transferase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SULT1C4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	35,494,614 - 35,504,162 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	35,495,727 - 35,504,125 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	35,417,189 - 35,426,790 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	36,347,852 - 36,357,542 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	36,347,858 - 36,357,539 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	36,076,446 - 36,086,062 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	36,364,428 - 36,374,052 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	36,552,740 - 36,562,343 (-)	NCBI		UU_Cfam_GSD_1.0

SULT1C4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	108,377,954 - 108,388,989 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	108,377,911 - 108,388,989 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	108,994,410 - 109,005,445 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	108,360,853 - 108,370,702 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	108,452,938 - 108,462,788	NCBI
Celera	2	103,302,687 - 103,312,533 (+)	NCBI		Celera
Cytogenetic Map	2	q12.3	NCBI
HuRef	2	102,593,594 - 102,603,444 (+)	NCBI		HuRef
CHM1_1	2	108,998,692 - 109,008,539 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	108,838,857 - 108,849,892 (+)	NCBI		T2T-CHM13v2.0

SULT1C4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	20,506,186 - 20,532,472 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	20,508,946 - 20,529,689 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	94,508,492 - 94,519,963 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	109,612,337 - 109,623,365 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	109,572,466 - 109,622,211 (+)	Ensembl	panpan1.1		panPan2

LOC100623441
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	47,766,407 - 47,776,867 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	47,765,022 - 47,777,178 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	49,934,288 - 49,946,616 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103241211
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	11,860,065 - 11,882,111 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	11,861,211 - 11,871,767 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	179,677,126 - 179,685,878 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in SULT1C4
171 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5		21	6	6	6	6		10		10	6
Low		5	1					6	2	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038488899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038550864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038614783	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038680150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_531771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000003238 ⟹ ENSCAFP00000003010

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	35,495,727 - 35,504,125 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000093828 ⟹ ENSCAFP00000063326

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	35,495,727 - 35,504,125 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845015393 ⟹ ENSCAFP00845011955

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	36,347,858 - 36,357,539 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845015413 ⟹ ENSCAFP00845011972

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	36,347,858 - 36,357,539 (-)	Ensembl

RefSeq Acc Id:

XM_038488899 ⟹ XP_038344827

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	10	36,076,446 - 36,086,062 (-)	NCBI

RefSeq Acc Id:

XM_038550864 ⟹ XP_038406792

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	10	36,552,740 - 36,562,343 (-)	NCBI

RefSeq Acc Id:

XM_038614783 ⟹ XP_038470711

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	10	36,364,428 - 36,374,052 (-)	NCBI

RefSeq Acc Id:

XM_038680150 ⟹ XP_038536078

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	36,347,852 - 36,357,542 (-)	NCBI

RefSeq Acc Id:

XM_531771 ⟹ XP_531771

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	35,494,614 - 35,504,162 (-)	NCBI
Dog10K_Boxer_Tasha	10	35,417,189 - 35,426,790 (-)	NCBI

Sequence:

show sequence

GGGCTGGAGCTCATTAAGAAAACGCCTGAGTACAAAGGCCTACATCGCAGTTCCGTGCTTCCTG
GAACTTGGGCGGACAGAGCTGTAGCTACTTTCTCCTTTGACTGACAGCCATCCCCAGCTGTCCA
GGAAGAATTTGCAGTCTGAATTTTGCATCGCCTGTGCAATAACAGAAGTGCAGCTTTGTGCTGA
CTGAGCAGTAACATTTTATCTGGAGCACTACTCTGATTTCTGACACTAATGGCCTTAAACAAAA
TGGAGGATTTTAAATTTGATGGAACAACACGCCTACCTGTCGCTTATGTGGAGGGGATTTTACA
ACCCACACCTACCTGTGACATCTGGGACCAGATCTGGAATTTCCAAGCCAAGTCTGATGATCTG
CTTATTGCCACCTATCCTAAAGCAGGAACAACATGGACTCAGGAGATAGTGGACTTAATACAAA
ATGAAGGGGATGTTGACAAAAGTCAAAGAGCACCTATTCATGTACGAATTCCTTTCATTGAATG
GATAATCCCATCCATTGGATCTGGTTTGGAAAGAGCTAATGAAATGCCCTCACCACGGACCCTG
AAAACACATCTTCCCATCCATTTGCTGCCACCATCCTTCATAGAAAAAAACTGCAAGATAATCT
ATGTGGCAAGAAATCCAAAGGACAATATGGTGTCTTATTACCATTTCCAAAGAATGAATAAATC
TCTTCCTGCTCCAGGAACCTGGGAAGAGTATTTTGAGAATTTTCTGGCTGGGAAAGTATGCTGG
GGTTCTTGGTATGACCACGTGAAAGGATGGTGGAAAGCCAAAGACCAACACCGCATTCTCTACC
TCTTCTATGAGGACCTGAAGAAGAATACAAAGCATGAAATTCAGAAGGTGGCAGAGTTTATTGG
AAAAAACCTAGATGATGAAATCCTAGATAAAATTGTCCATCACACTTCATTTGATGTTATGAAG
GAGAATCCAATGTCAAACTATTCATCAGTTCCTGCTAAAATCATGAACCACTCTGTGTCTCCAT
TCATGAGAAAAGGGATAGTTGGAGACTGGAAGAATCACTTTACCGTGGCTCAGAATGAAAGATT
TAATGAAGACTACAAGAAGAAAATGGCTGATACCAATCTAACTTTTCACTTCCAATTCTCATAA
AAAAGAAAAGAACCAACATTTTTTTAGTTTGTTACTTAATTTACTGGTAATAACCAATAAAACT
TTATTACCCACATGATACTAAATTCAGATTCTCAGACTAGCTGTGTATTATATTTGCTCTTGCT
CACTCTAAAAAAAATAGGAATAAAGCTAGCAGAGATTGAGCACAAGGTAGAAAGTGGAAGCATG
ATAGCATGTGGAGGAAGAAGGTTCAATAATTACTAATTACAATCATGGCATCATCGCTGATTAT
CATAATATTTATGTTTTCGACAGGTCATGTGTTTGTTGACATACTAGAAATGTCTCATTCCTTG
TGTAAGAAAACACTAAAGCTTTCAAAGTAAGCATTGGTTCAGGCTAATTTTTCAATGCAGCACT
AAAATATGTAGATAGTGACTATCTCTCCCAGAAATTTCTTGGTAGTCAAGTAACCATCAAGTGA
CTGTTTCCTCATAAAACTTTCTGATTCACTTCAGTGTTCCTCCTATAATACATCTATGCCTATC
TCTTACCACATCATATATACTTAACTCTTTTTCTCACCCCAGTTAATGCCGATTGAGTCTTGGA
GTCACATCTTGACTCTTTACGTCTATGGAGTCTTGTTCGTGTAGCCACCCTTCTGGCTCAGAAA
CATGTAACCTCTTGCCCATACTAGTATAAGCTTCATAACTCGTTTCTCTGTCTCTCACACATCT
ACCAGGGTTACTTTCCTAAAACAAAATTTCATTATATTTCTCTTTAGCTCTAAATCCTATGTTT
TTTTAGCCATCAATTCAAAGGGAGCTATAATGATATGATATGGTAGATCTCACCTTCCAAAACA
CTTTTCTAGCTTAATTTCACCTTCTAAACCACTTCCATACTTCAGCAAATAAGTCTACTCACTG
AGTCCTAATCACATCTTGCAGGTTCCTATCCTACTAGTTTTATTTTTACCATGCCTCCATCTGA
AATTTCCTTTCCTTTCTTTCTACCTATCCAAAATATATAACATGCTTCAATAACCAGTGCAAGT
AGTTCATTATCCTGAAGATAGCATTTGCTTTTCTGAAGTCCTCTACACTTGGTATAATTCATTT
GTCATTAAAATTAAAGTATATTGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038344827	(Get FASTA)	NCBI Sequence Viewer
	XP_038406792	(Get FASTA)	NCBI Sequence Viewer
	XP_038470711	(Get FASTA)	NCBI Sequence Viewer
	XP_038536078	(Get FASTA)	NCBI Sequence Viewer
	XP_531771	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000003010.3
	ENSCAFP00000063326.1
	ENSCAFP00030036234.1
	ENSCAFP00030036288.1
	ENSCAFP00040026115.1
	ENSCAFP00040026141.1
	ENSCAFP00845011955
	ENSCAFP00845011955.1
	ENSCAFP00845011972.1

RefSeq Acc Id:

XP_531771 ⟸ XM_531771

- UniProtKB:

A0A8C0KCE6 (UniProtKB/TrEMBL), A0A8C0YZR2 (UniProtKB/TrEMBL), A0A8I3N072 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALNKMEDFKFDGTTRLPVAYVEGILQPTPTCDIWDQIWNFQAKSDDLLIATYPKAGTTWTQEI
VDLIQNEGDVDKSQRAPIHVRIPFIEWIIPSIGSGLERANEMPSPRTLKTHLPIHLLPPSFIEK
NCKIIYVARNPKDNMVSYYHFQRMNKSLPAPGTWEEYFENFLAGKVCWGSWYDHVKGWWKAKDQ
HRILYLFYEDLKKNTKHEIQKVAEFIGKNLDDEILDKIVHHTSFDVMKENPMSNYSSVPAKIMN
HSVSPFMRKGIVGDWKNHFTVAQNERFNEDYKKKMADTNLTFHFQFS

hide sequence

RefSeq Acc Id:

ENSCAFP00000063326 ⟸ ENSCAFT00000093828

RefSeq Acc Id:

ENSCAFP00000003010 ⟸ ENSCAFT00000003238

RefSeq Acc Id:

XP_038344827 ⟸ XM_038488899

RefSeq Acc Id:

XP_038470711 ⟸ XM_038614783

RefSeq Acc Id:	XP_038536078 ⟸ XM_038680150
- UniProtKB:	A0A8C0KCE6 (UniProtKB/TrEMBL), A0A8C0YZR2 (UniProtKB/TrEMBL), A0A8I3N072 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038406792 ⟸ XM_038550864
- UniProtKB:	A0A8C0KCE6 (UniProtKB/TrEMBL), A0A8C0YZR2 (UniProtKB/TrEMBL), A0A8I3N072 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845011955 ⟸ ENSCAFT00845015393

RefSeq Acc Id:

ENSCAFP00845011972 ⟸ ENSCAFT00845015413

Protein Domains

Sulfotransferase

Promoters

RGD ID:

13685019

Promoter ID:

EPDNEW_C3085

Type:

initiation region

Name:

SULT1C4_1

Description:

sulfotransferase family 1C member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	35,504,116 - 35,504,176	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000023655	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030022586	UniProtKB/TrEMBL
	ENSCAFG00040016285	UniProtKB/TrEMBL
	ENSCAFG00845008747	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000003238.5	UniProtKB/TrEMBL
	ENSCAFT00000093828.2	UniProtKB/TrEMBL
	ENSCAFT00030041535.1	UniProtKB/TrEMBL
	ENSCAFT00030041590.1	UniProtKB/TrEMBL
	ENSCAFT00040030056.1	UniProtKB/TrEMBL
	ENSCAFT00040030086.1	UniProtKB/TrEMBL
	ENSCAFT00845015393	ENTREZGENE
	ENSCAFT00845015393.1	UniProtKB/TrEMBL
	ENSCAFT00845015413.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Sulfotransferase_dom	UniProtKB/TrEMBL
KEGG Report	cfa:474542	UniProtKB/TrEMBL
NCBI Gene	SULT1C4	ENTREZGENE
PANTHER	SULFOTRANSFERASE 1C4	UniProtKB/TrEMBL
	SULFOTRANSFERASE SULT	UniProtKB/TrEMBL
Pfam	Sulfotransfer_1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A8C0KCE6	ENTREZGENE
	A0A8C0P7X5_CANLF	UniProtKB/TrEMBL
	A0A8C0YZR2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3N072	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RUS4_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:46978	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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