HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8)

Gene: HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8) Canis lupus familiaris

Analyze

Symbol:

HSD17B8

Name:

hydroxysteroid 17-beta dehydrogenase 8

RGD ID:

12224231

Description:

ENCODES a protein that exhibits (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity (ortholog); estradiol 17-beta-dehydrogenase [NAD(P)] activity (ortholog); NADH binding (ortholog); INVOLVED IN androgen metabolic process (ortholog); estrogen biosynthetic process (ortholog); estrogen metabolic process (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 5 (ortholog); proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN mitochondrial envelope (ortholog); oxidoreductase complex (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

(3R)-3-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 8; 17-beta-hydroxysteroid dehydrogenase 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; Estradiol 17-beta-dehydrogenase 8; KAR alpha subunit; Testosterone 17-beta-dehydrogenase 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,667,674 - 2,669,918 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	2,663,515 - 2,669,917 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	2,748,819 - 2,751,058 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	2,998,414 - 3,000,653 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	2,998,475 - 3,000,551 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	2,666,602 - 2,668,840 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,747,969 - 2,750,208 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,822,541 - 2,824,780 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 5 (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen metabolic process (ISO)

estrogen biosynthetic process (IBA,IEA,ISS)

estrogen metabolic process (ISO)

fatty acid biosynthetic process (IEA,ISS)

fatty acid metabolic process (IEA)

intracellular zinc ion homeostasis (IEA)

metal ion transport (IEA)

protein heterotetramerization (ISS)

steroid biosynthetic process (IEA)

transmembrane transport (IEA)

zinc ion transmembrane transport (IEA)

Cellular Component

Golgi apparatus (IEA)

membrane (IEA)

mitochondrial envelope (ISO)

mitochondrial matrix (IEA)

mitochondrion (IEA)

oxidoreductase complex (ISO)

plasma membrane (ISO)

Molecular Function

(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity (IEA,ISS)

estradiol 17-beta-dehydrogenase [NAD(P)] activity (IBA,IEA,ISS)

metal ion transmembrane transporter activity (IEA)

NADH binding (ISS)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on CH-OH group of donors (IEA)

protein binding (ISO)

testosterone dehydrogenase (NAD+) activity (IEA)

zinc ion transmembrane transporter activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

HSD17B8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,667,674 - 2,669,918 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	2,663,515 - 2,669,917 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	2,748,819 - 2,751,058 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	2,998,414 - 3,000,653 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	2,998,475 - 3,000,551 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	2,666,602 - 2,668,840 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,747,969 - 2,750,208 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,822,541 - 2,824,780 (+)	NCBI		UU_Cfam_GSD_1.0

HSD17B8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	33,204,655 - 33,206,831 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	33,204,655 - 33,206,831 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	33,172,432 - 33,174,608 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	33,280,397 - 33,282,585 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	33,280,396 - 33,282,585	NCBI
Celera	6	34,726,785 - 34,728,973 (+)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	32,914,459 - 32,916,653 (+)	NCBI		HuRef
CHM1_1	6	33,174,288 - 33,176,486 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,026,008 - 33,028,184 (+)	NCBI		T2T-CHM13v2.0

Hsd17b8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,245,007 - 34,247,029 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,245,007 - 34,247,034 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,026,033 - 34,028,055 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,026,033 - 34,028,060 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,162,978 - 34,165,000 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	33,636,489 - 33,638,511 (-)	NCBI		MGSCv36	mm8
Celera	17	36,772,162 - 36,774,185 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.98	NCBI

Hsd17b8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	4,828,571 - 4,830,635 (+)	NCBI		GRCr8
mRatBN7.2	20	4,826,725 - 4,828,742 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,822,026 - 4,828,742 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,578,527 - 5,580,523 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,940,281 - 4,942,277 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	5,421,165 - 5,423,160 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	3,817,212 - 3,819,316 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	3,817,179 - 3,819,235 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	5,896,543 - 5,898,654 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,964,860 - 4,966,855 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,965,086 - 4,967,082 (+)	NCBI
Celera	20	6,426,931 - 6,428,926 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Hsd17b8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	1,778,276 - 1,780,397 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	1,778,276 - 1,780,397 (+)	NCBI	ChiLan1.0	ChiLan1.0

HSD17B8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	47,682,351 - 47,684,652 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	43,554,020 - 43,556,322 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	32,776,837 - 32,779,042 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	33,891,753 - 33,893,950 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	33,891,753 - 33,893,950 (+)	Ensembl	panpan1.1		panPan2

Hsd17b8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,309,422 - 38,311,663 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	25,648,604 - 25,650,757 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	25,648,604 - 25,650,757 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD17B8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	25,247,608 - 25,249,785 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	25,247,577 - 25,249,786 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	29,753,837 - 29,756,042 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSD17B8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,868,307 - 38,870,564 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,868,685 - 38,870,459 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	33,038,755 - 33,041,527 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsd17b8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,600,706 - 23,602,751 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	23,600,706 - 23,602,786 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HSD17B8
23 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005627198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014118363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014118364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038491485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038491486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038491487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038491488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038553708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038553709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038553710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038553711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038617571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038617572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038617573	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038617574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038683179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038683180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038683181	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038683182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_845911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ630366	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000001426 ⟹ ENSCAFP00000001312

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	12	2,663,515 - 2,667,527 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000001431 ⟹ ENSCAFP00000001317

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	12	2,667,740 - 2,669,816 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000072842 ⟹ ENSCAFP00000059021

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	12	2,663,515 - 2,669,917 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000076851 ⟹ ENSCAFP00000061947

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	12	2,663,515 - 2,667,527 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000085978 ⟹ ENSCAFP00000065513

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	12	2,663,515 - 2,669,917 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845036315 ⟹ ENSCAFP00845028421

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	12	2,998,475 - 3,000,551 (+)	Ensembl

RefSeq Acc Id:

XM_005627198 ⟹ XP_005627255

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	12	2,667,675 - 2,669,888 (+)	NCBI
Dog10K_Boxer_Tasha	12	2,748,820 - 2,751,016 (+)	NCBI

Sequence:

show sequence

GATTGGCGCGGCTGCGCCCTGGCCACGCCCCCTGGCTGGGATTGGCTGAGTGCTGGGTGTCCGC
CCGCCCGCCCGCCTGACATGGCGTCTCCGCTCAGGCTCCGCTCCGCGCTGGCCCTGGTCACAGG
CGCGGGTAGCGGCATCGGCAGGGCCGTCAGTGTACGCCTGGCCAAAGAGGGGGCCACTGTGGCC
GCTTGCGACTTGGACCGGGCGGCGGCTTGCGAGACGGTGTGGCTGCTGGGCGGGCAGGGGAGCG
AGAAGGTGGCGCCCGGCGGGGCCCACACCGCCTTCCAGGCTGACGTGTCTGAGGCCGGGGCGGT
CAGGCGCCTGCTGGAACAAGTACAGGCCTGCTTTTCTCGCCCGCCATCTGTCGTCGTCTCCTGT
GCAGGCCTCACCAGGGATGAGTTTCTGCTCCGCATGTCTGAGGATGACTGGGACAGAGTCATAG
CTGTCAACCTCAAGGGCATCTTTCTAGTCACTCAGGCTGCAGCCCAAGCCCTGGTGTCCAGTGG
TTGCCGTGGGTCCATCATCAACATCAGTAGCATCGTAGGGAAGGTAGGGAACGTGGGACAGACA
AACTATGCAGCATCCAAGGCTGGAGTGATTGGCCTGACCCAGACTGCAGCTCGGGAGCTTGGAC
GGTTGGTCAGACACCCCTGGGGACACGGGATCCGCTGTAACTCTGTCCTCCCAGGGTTCATTAC
AACACCCATGACACAGAAAGTGCCACAGAAAGTGCTGGACAAGGTGATTGGAATGATTCCGATG
GGACATTTGGGGGATCCTGAGGATGTCGCAGATGCGGTCACATTCTTGGCGTCTGAAGACAGTG
GATACATCACAGGCGCCTCAGTGGAAGTCACTGGAGGTCTTTTCATGTAACTGCCTCACGGACC
CTGGACTCTGCTCACTCCCCCACCACTCCAACCGGCCTCCTGCTGATGAGGACTCTGAGTTCCC
AGGCTACAAAAGGCGCAGCAGTGTATGGCTCTGGAATGCTGAATATGGGAGGCAGGGGTGCTTG
TGACC

hide sequence

RefSeq Acc Id:

XM_014118363 ⟹ XP_013973838

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	12	2,667,674 - 2,669,918 (+)	NCBI
Dog10K_Boxer_Tasha	12	2,748,819 - 2,751,058 (+)	NCBI

Sequence:

show sequence

AGATTGGCGCGGCTGCGCCCTGGCCACGCCCCCTGGCTGGGATTGGCTGAGTGCTGGGTGTCCG
CCCGCCCGCCCGCCTGACATGGCGTCTCCGCTCAGGCTCCGCTCCGCGCTGGCCCTGGTCACAG
GCGCGGGTAGCGGCATCGGCAGGGCCGTCAGTGTACGCCTGGCCAAAGAGGGGGCCACTGTGGC
CGCTTGCGACTTGGACCGGGCGGCGGCTTGCGAGACGGTGTGGCTGCTGGGCGGGCAGGGGAGC
GAGAAGGTGGCGCCCGGCGGGGCCCACACCGCCTTCCAGGCTGACGTGTCTGAGGCCGGGGCGG
TCAGGCGCCTGCTGGAACAAGTACAGGCCTGCTTTTCTCGCCCGCCATCTGTCGTCGTCTCCTG
TGCAGGCCTCACCAGGGATGAGTTTCTGCTCCGCATGTCTGAGGATGACTGGGACAGAGTCATA
GCTGTCAACCTCAAGGGCATCTTTCTAGTCACTCAGGCTGCAGCCCAAGCCCTGGTGTCCAGTG
GTTGCCGTGGGTCCATCATCAACATCAGTAGCATCGTAGGGAAGGTAGGGAACGTGGGACAGAC
AAACTATGCAGCATCCAAGGCTGGAGTGATTGGCCTGACCCAGACTGCAGCTCGGGAGCTTGGA
CGGTTGGTCAGACACCCCTGGGGACACGGGATCCGCTGTAACTCTGTCCTCCCAGGGTTCATTA
CAACACCCATGACACAGAAAGTGCCACAGAAAGTGCTGGACAAGATGTCGCAGATGCGGTCACA
TTCTTGGCGTCTGAAGACAGTGGATACATCACAGGCGCCTCAGTGGAAGTCACTGGAGGTCTTT
TCATGTAACTGCCTCACGGACCCTGGACTCTGCTCACTCCCCCACCACTCCAACCGGCCTCCTG
CTGATGAGGACTCTGAGTTCCCAGGCTACAAAAGGCGCAGCAGTGTATGGCTCTGGAATGCTGA
ATATGGGAGGCAGGGGTGCTTGTGACCCTAATAAATTCCAAATCCTCTTCCCTGCCA

hide sequence

RefSeq Acc Id:

XM_014118364 ⟹ XP_013973839

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	12	2,667,675 - 2,669,918 (+)	NCBI
Dog10K_Boxer_Tasha	12	2,748,820 - 2,751,058 (+)	NCBI

Sequence:

show sequence

GATTGGCGCGGCTGCGCCCTGGCCACGCCCCCTGGCTGGGATTGGCTGAGTGCTGGGTGTCCGC
CCGCCCGCCCGCCTGACATGGCGTCTCCGCTCAGGCTCCGCTCCGCGCTGGCCCTGGTCACAGG
CGCGGGTAGCGGCATCGGCAGGGCCGTCAGTGTACGCCTGGCCAAAGAGGGGGCCACTGTGGCC
GCTTGCGACTTGGACCGGGCGGCGGCTTGCGAGACGGTGTGGCTGCTGGGCGGGCAGGGGAGCG
AGAAGGTGGCGCCCGGCGGGGCCCACACCGCCTTCCAGGCTGACGTGTCTGAGGCCGGGGCGGT
CAGGCGCCTGCTGGAACAAGTACAGGCCTGCTTTTCTCGCCCGCCATCTGTCGTCGTCTCCTGT
GCAGGCCTCACCAGGGATGAGTTTCTGCTCCGCATGTCTGAGGATGACTGGGACAGAGTCATAG
CTGTCAACCTCAAGGGCATCTTTCTAGTCACTCAGGCTGCAGCCCAAGCCCTGGTGTCCAGTGG
TTGCCGTGGGTCCATCATCAACATCAGTAGCATCGTAGGGAAGGTAGGGAACGTGGGACAGACA
AACTATGCAGCATCCAAGGCTGGAGTGATTGGCCTGACCCAGACTGCAGCTCGGGAGCTTGGAC
GACACGGGATCCGCTGTAACTCTGTCCTCCCAGGGTTCATTACAACACCCATGACACAGAAAGT
GCCACAGAAAGTGCTGGACAAGATGTCGCAGATGCGGTCACATTCTTGGCGTCTGAAGACAGTG
GATACATCACAGGCGCCTCAGTGGAAGTCACTGGAGGTCTTTTCATGTAACTGCCTCACGGACC
CTGGACTCTGCTCACTCCCCCACCACTCCAACCGGCCTCCTGCTGATGAGGACTCTGAGTTCCC
AGGCTACAAAAGGCGCAGCAGTGTATGGCTCTGGAATGCTGAATATGGGAGGCAGGGGTGCTTG
TGACCCTAATAAATTCCAAATCCTCTTCCCTGCCA

hide sequence

RefSeq Acc Id:

XM_038491485 ⟹ XP_038347413

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	12	2,666,602 - 2,668,840 (+)	NCBI

RefSeq Acc Id:

XM_038491486 ⟹ XP_038347414

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	12	2,666,603 - 2,668,840 (+)	NCBI

RefSeq Acc Id:

XM_038491487 ⟹ XP_038347415

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	12	2,666,603 - 2,668,798 (+)	NCBI

RefSeq Acc Id:

XM_038491488 ⟹ XP_038347416

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	12	2,666,603 - 2,668,840 (+)	NCBI

RefSeq Acc Id:

XM_038553708 ⟹ XP_038409636

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	12	2,822,541 - 2,824,780 (+)	NCBI

RefSeq Acc Id:

XM_038553709 ⟹ XP_038409637

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	12	2,822,542 - 2,824,780 (+)	NCBI

RefSeq Acc Id:

XM_038553710 ⟹ XP_038409638

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	12	2,822,542 - 2,824,738 (+)	NCBI

RefSeq Acc Id:

XM_038553711 ⟹ XP_038409639

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	12	2,822,542 - 2,824,780 (+)	NCBI

RefSeq Acc Id:

XM_038617571 ⟹ XP_038473499

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	12	2,747,969 - 2,750,208 (+)	NCBI

RefSeq Acc Id:

XM_038617572 ⟹ XP_038473500

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	12	2,747,970 - 2,750,208 (+)	NCBI

RefSeq Acc Id:

XM_038617573 ⟹ XP_038473501

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	12	2,747,970 - 2,750,166 (+)	NCBI

RefSeq Acc Id:

XM_038617574 ⟹ XP_038473502

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	12	2,747,970 - 2,750,208 (+)	NCBI

RefSeq Acc Id:

XM_038683179 ⟹ XP_038539107

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	12	2,998,414 - 3,000,653 (+)	NCBI

RefSeq Acc Id:

XM_038683180 ⟹ XP_038539108

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	12	2,998,415 - 3,000,653 (+)	NCBI

RefSeq Acc Id:

XM_038683181 ⟹ XP_038539109

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	12	2,998,415 - 3,000,611 (+)	NCBI

RefSeq Acc Id:

XM_038683182 ⟹ XP_038539110

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	12	2,998,415 - 3,000,653 (+)	NCBI

RefSeq Acc Id:

XM_845911 ⟹ XP_851004

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	12	2,667,675 - 2,669,918 (+)	NCBI
Dog10K_Boxer_Tasha	12	2,748,820 - 2,751,058 (+)	NCBI

Sequence:

show sequence

GATTGGCGCGGCTGCGCCCTGGCCACGCCCCCTGGCTGGGATTGGCTGAGTGCTGGGTGTCCGC
CCGCCCGCCCGCCTGACATGGCGTCTCCGCTCAGGCTCCGCTCCGCGCTGGCCCTGGTCACAGG
CGCGGGTAGCGGCATCGGCAGGGCCGTCAGTGTACGCCTGGCCAAAGAGGGGGCCACTGTGGCC
GCTTGCGACTTGGACCGGGCGGCGGCTTGCGAGACGGTGTGGCTGCTGGGCGGGCAGGGGAGCG
AGAAGGTGGCGCCCGGCGGGGCCCACACCGCCTTCCAGGCTGACGTGTCTGAGGCCGGGGCGGT
CAGGCGCCTGCTGGAACAAGTACAGGCCTGCTTTTCTCGCCCGCCATCTGTCGTCGTCTCCTGT
GCAGGCCTCACCAGGGATGAGTTTCTGCTCCGCATGTCTGAGGATGACTGGGACAGAGTCATAG
CTGTCAACCTCAAGGGCATCTTTCTAGTCACTCAGGCTGCAGCCCAAGCCCTGGTGTCCAGTGG
TTGCCGTGGGTCCATCATCAACATCAGTAGCATCGTAGGGAAGGTAGGGAACGTGGGACAGACA
AACTATGCAGCATCCAAGGCTGGAGTGATTGGCCTGACCCAGACTGCAGCTCGGGAGCTTGGAC
GACACGGGATCCGCTGTAACTCTGTCCTCCCAGGGTTCATTACAACACCCATGACACAGAAAGT
GCCACAGAAAGTGCTGGACAAGGTGATTGGAATGATTCCGATGGGACATTTGGGGGATCCTGAG
GATGTCGCAGATGCGGTCACATTCTTGGCGTCTGAAGACAGTGGATACATCACAGGCGCCTCAG
TGGAAGTCACTGGAGGTCTTTTCATGTAACTGCCTCACGGACCCTGGACTCTGCTCACTCCCCC
ACCACTCCAACCGGCCTCCTGCTGATGAGGACTCTGAGTTCCCAGGCTACAAAAGGCGCAGCAG
TGTATGGCTCTGGAATGCTGAATATGGGAGGCAGGGGTGCTTGTGACCCTAATAAATTCCAAAT
CCTCTTCCCTGCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005627255	(Get FASTA)	NCBI Sequence Viewer
	XP_013973838	(Get FASTA)	NCBI Sequence Viewer
	XP_013973839	(Get FASTA)	NCBI Sequence Viewer
	XP_038347413	(Get FASTA)	NCBI Sequence Viewer
	XP_038347414	(Get FASTA)	NCBI Sequence Viewer
	XP_038347415	(Get FASTA)	NCBI Sequence Viewer
	XP_038347416	(Get FASTA)	NCBI Sequence Viewer
	XP_038409636	(Get FASTA)	NCBI Sequence Viewer
	XP_038409637	(Get FASTA)	NCBI Sequence Viewer
	XP_038409638	(Get FASTA)	NCBI Sequence Viewer
	XP_038409639	(Get FASTA)	NCBI Sequence Viewer
	XP_038473499	(Get FASTA)	NCBI Sequence Viewer
	XP_038473500	(Get FASTA)	NCBI Sequence Viewer
	XP_038473501	(Get FASTA)	NCBI Sequence Viewer
	XP_038473502	(Get FASTA)	NCBI Sequence Viewer
	XP_038539107	(Get FASTA)	NCBI Sequence Viewer
	XP_038539108	(Get FASTA)	NCBI Sequence Viewer
	XP_038539109	(Get FASTA)	NCBI Sequence Viewer
	XP_038539110	(Get FASTA)	NCBI Sequence Viewer
	XP_851004	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAI11433	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000001317.2
	ENSCAFP00040033307.1
	ENSCAFP00040033480.1
	ENSCAFP00845028421
	ENSCAFP00845028421.1
GenBank Protein	Q5TJF5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_013973838 ⟸ XM_014118363

- Peptide Label:

isoform X1

- Sequence:

show sequence

MASPLRLRSALALVTGAGSGIGRAVSVRLAKEGATVAACDLDRAAACETVWLLGGQGSEKVAPG
GAHTAFQADVSEAGAVRRLLEQVQACFSRPPSVVVSCAGLTRDEFLLRMSEDDWDRVIAVNLKG
IFLVTQAAAQALVSSGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRLVRHP
WGHGIRCNSVLPGFITTPMTQKVPQKVLDKMSQMRSHSWRLKTVDTSQAPQWKSLEVFSCNCLT
DPGLCSLPHHSNRPPADEDSEFPGYKRRSSVWLWNAEYGRQGCL

hide sequence

RefSeq Acc Id:	XP_851004 ⟸ XM_845911
- Peptide Label:	isoform X4
- UniProtKB:	A0A8C0TC64 (UniProtKB/TrEMBL), A0A8P0S6V8 (UniProtKB/TrEMBL), A0A8C0JNZ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASPLRLRSALALVTGAGSGIGRAVSVRLAKEGATVAACDLDRAAACETVWLLGGQGSEKVAPG GAHTAFQADVSEAGAVRRLLEQVQACFSRPPSVVVSCAGLTRDEFLLRMSEDDWDRVIAVNLKG IFLVTQAAAQALVSSGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRC NSVLPGFITTPMTQKVPQKVLDKVIGMIPMGHLGDPEDVADAVTFLASEDSGYITGASVEVTGG LFM hide sequence

RefSeq Acc Id:

XP_013973839 ⟸ XM_014118364

- Peptide Label:

isoform X2

- Sequence:

show sequence

MASPLRLRSALALVTGAGSGIGRAVSVRLAKEGATVAACDLDRAAACETVWLLGGQGSEKVAPG
GAHTAFQADVSEAGAVRRLLEQVQACFSRPPSVVVSCAGLTRDEFLLRMSEDDWDRVIAVNLKG
IFLVTQAAAQALVSSGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRC
NSVLPGFITTPMTQKVPQKVLDKMSQMRSHSWRLKTVDTSQAPQWKSLEVFSCNCLTDPGLCSL
PHHSNRPPADEDSEFPGYKRRSSVWLWNAEYGRQGCL

hide sequence

RefSeq Acc Id:	XP_005627255 ⟸ XM_005627198
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0JNZ3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASPLRLRSALALVTGAGSGIGRAVSVRLAKEGATVAACDLDRAAACETVWLLGGQGSEKVAPG GAHTAFQADVSEAGAVRRLLEQVQACFSRPPSVVVSCAGLTRDEFLLRMSEDDWDRVIAVNLKG IFLVTQAAAQALVSSGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRLVRHP WGHGIRCNSVLPGFITTPMTQKVPQKVLDKVIGMIPMGHLGDPEDVADAVTFLASEDSGYITGA SVEVTGGLFM hide sequence

RefSeq Acc Id:

ENSCAFP00000001317 ⟸ ENSCAFT00000001431

RefSeq Acc Id:

ENSCAFP00000001312 ⟸ ENSCAFT00000001426

RefSeq Acc Id:

ENSCAFP00000061947 ⟸ ENSCAFT00000076851

RefSeq Acc Id:

ENSCAFP00000059021 ⟸ ENSCAFT00000072842

RefSeq Acc Id:

ENSCAFP00000065513 ⟸ ENSCAFT00000085978

RefSeq Acc Id:	XP_038347413 ⟸ XM_038491485
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038347416 ⟸ XM_038491488
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038347414 ⟸ XM_038491486
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038347415 ⟸ XM_038491487
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038473499 ⟸ XM_038617571
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038473502 ⟸ XM_038617574
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038473500 ⟸ XM_038617572
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038473501 ⟸ XM_038617573
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038539107 ⟸ XM_038683179
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038539110 ⟸ XM_038683182
- Peptide Label:	isoform X4
- UniProtKB:	Q5TJF5 (UniProtKB/Swiss-Prot), A0A8C0QUD7 (UniProtKB/TrEMBL), A0A8C0JNZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038539108 ⟸ XM_038683180
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038539109 ⟸ XM_038683181
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0JNZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038409636 ⟸ XM_038553708
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038409639 ⟸ XM_038553711
- Peptide Label:	isoform X4
- UniProtKB:	A0A8C0JNZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038409637 ⟸ XM_038553709
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038409638 ⟸ XM_038553710
- Peptide Label:	isoform X3
- UniProtKB:	A0A8C0JNZ3 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845028421 ⟸ ENSCAFT00845036315

Promoters

RGD ID:

13685377

Promoter ID:

EPDNEW_C3443

Type:

multiple initiation site

Name:

HSD17B8_1

Description:

hydroxysteroid 17-beta dehydrogenase 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	12	2,667,745 - 2,667,805	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000000917	Ensembl
	ENSCAFG00000055140	UniProtKB/TrEMBL
	ENSCAFG00040020645	UniProtKB/TrEMBL
	ENSCAFG00845020603	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSCAFT00000001431.4	UniProtKB/TrEMBL
	ENSCAFT00040038204.1	UniProtKB/TrEMBL
	ENSCAFT00040038387.1	UniProtKB/TrEMBL
	ENSCAFT00845036315	ENTREZGENE
	ENSCAFT00845036315.1	UniProtKB/Swiss-Prot
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDR_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZIP	UniProtKB/TrEMBL
NCBI Gene	HSD17B8	ENTREZGENE
PANTHER	(3R)-3-HYDROXYACYL-COA DEHYDROGENASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZINC TRANSPORTER SLC39A7	UniProtKB/TrEMBL
	ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4	UniProtKB/TrEMBL
Pfam	adh_short_C2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Zip	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	PKS_KR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8C0JNZ3	ENTREZGENE
	A0A8C0QUD7	ENTREZGENE
	A0A8C0T8E6_CANLF	UniProtKB/TrEMBL
	A0A8C0TC64	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0S6V8	ENTREZGENE
	DHB8_CANLF	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A8P0S6V8	UniProtKB/TrEMBL
VGNC ID	VGNC:41810	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar