KLF14 (KLF transcription factor 14) - Rat Genome Database

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Gene: KLF14 (KLF transcription factor 14) Canis lupus familiaris
Analyze
Symbol: KLF14
Name: KLF transcription factor 14
RGD ID: 12173686
Description: ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN positive regulation of sphingolipid mediated signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Dyslipidemias (ortholog); genetic disease (ortholog); Insulin Resistance (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Krueppel-like factor 14; Kruppel like factor 14
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1146,289,163 - 6,292,459 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl146,289,163 - 6,290,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,949,440 - 5,952,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0146,023,394 - 6,026,547 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl146,023,394 - 6,024,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1146,228,821 - 6,231,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0145,973,983 - 5,977,136 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,117,539 - 6,120,692 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
KLF14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1146,289,163 - 6,292,459 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl146,289,163 - 6,290,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha145,949,440 - 5,952,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0146,023,394 - 6,026,547 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl146,023,394 - 6,024,341 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1146,228,821 - 6,231,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0145,973,983 - 5,977,136 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,117,539 - 6,120,692 (+)NCBIUU_Cfam_GSD_1.0
KLF14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387130,730,697 - 130,734,207 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7130,730,697 - 130,734,207 (-)EnsemblGRCh38hg38GRCh38
GRCh377130,415,525 - 130,418,967 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367130,068,018 - 130,069,400 (-)NCBINCBI36Build 36hg18NCBI36
Build 347129,874,732 - 129,876,115NCBI
Celera7125,165,236 - 125,166,729 (-)NCBICelera
Cytogenetic Map7q32.2NCBI
HuRef7124,732,836 - 124,734,091 (-)NCBIHuRef
CHM1_17130,350,998 - 130,352,477 (-)NCBICHM1_1
T2T-CHM13v2.07132,044,973 - 132,048,483 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27129,753,857 - 129,755,336 (-)NCBI
Klf14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39630,932,956 - 30,935,925 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl630,932,958 - 30,936,013 (-)EnsemblGRCm39 Ensembl
GRCm38630,956,021 - 30,958,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl630,956,023 - 30,959,078 (-)EnsemblGRCm38mm10GRCm38
MGSCv37630,906,021 - 30,908,990 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36630,887,883 - 30,893,920 (-)NCBIMGSCv36mm8
MGSCv36631,109,536 - 31,115,573 (-)NCBIMGSCv36mm8
Celera630,940,993 - 30,943,962 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.54NCBI
Klf14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8460,521,363 - 60,524,285 (-)NCBIGRCr8
mRatBN7.2459,554,011 - 59,556,933 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl459,554,011 - 59,556,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx464,525,020 - 64,527,942 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0460,441,206 - 60,444,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,843,148 - 58,846,070 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0458,247,876 - 58,250,798 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl458,247,876 - 58,250,798 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0458,003,838 - 58,006,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4458,010,538 - 58,013,460 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1458,234,580 - 58,434,364 (-)NCBI
Celera454,647,664 - 54,650,586 (-)NCBICelera
Cytogenetic Map4q22NCBI
Klf14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541036,891,213 - 36,932,136 (+)NCBIChiLan1.0ChiLan1.0
KLF14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26167,549,657 - 167,551,313 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1719,558,044 - 19,561,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07122,695,015 - 122,696,635 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17135,211,891 - 135,212,975 (-)NCBIpanpan1.1PanPan1.1panPan2
Klf14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511824,454,475 - 24,455,914 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365794,587,081 - 4,588,010 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365794,587,072 - 4,588,505 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,147,124 - 18,149,177 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,147,124 - 18,149,177 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21819,167,742 - 19,169,796 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLF14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12199,361,461 - 99,363,067 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2199,361,955 - 99,362,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660424,025,569 - 4,027,384 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247835,593,860 - 5,594,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247835,593,860 - 5,595,803 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KLF14
19 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low
Below cutoff 7 2 3 9 3 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000038275   ⟹   ENSCAFP00000033964
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl146,289,163 - 6,290,110 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845029185   ⟹   ENSCAFP00845022952
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl146,023,394 - 6,024,341 (+)Ensembl
RefSeq Acc Id: XM_038495278   ⟹   XP_038351206
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1146,228,821 - 6,231,974 (+)NCBI
RefSeq Acc Id: XM_038556373   ⟹   XP_038412301
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0146,117,539 - 6,120,692 (+)NCBI
RefSeq Acc Id: XM_038620294   ⟹   XP_038476222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0145,973,983 - 5,977,136 (+)NCBI
RefSeq Acc Id: XM_038685971   ⟹   XP_038541899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0146,023,394 - 6,026,547 (+)NCBI
RefSeq Acc Id: XM_539373   ⟹   XP_539373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1146,289,163 - 6,292,459 (+)NCBI
Dog10K_Boxer_Tasha145,949,440 - 5,952,593 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_539373   ⟸   XM_539373
- UniProtKB: A0A8C0LDE5 (UniProtKB/TrEMBL),   A0A8C0P030 (UniProtKB/TrEMBL),   A0A8I3NZV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000033964   ⟸   ENSCAFT00000038275
RefSeq Acc Id: XP_038351206   ⟸   XM_038495278
RefSeq Acc Id: XP_038476222   ⟸   XM_038620294
RefSeq Acc Id: XP_038541899   ⟸   XM_038685971
- UniProtKB: A0A8C0LDE5 (UniProtKB/TrEMBL),   A0A8C0P030 (UniProtKB/TrEMBL),   A0A8I3NZV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412301   ⟸   XM_038556373
- UniProtKB: A0A8C0LDE5 (UniProtKB/TrEMBL),   A0A8C0P030 (UniProtKB/TrEMBL),   A0A8I3NZV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845022952   ⟸   ENSCAFT00845029185
Protein Domains
C2H2-type

Promoters
RGD ID:13685698
Promoter ID:EPDNEW_C3767
Type:multiple initiation site
Name:KLF14_1
Description:Kruppel like factor 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1146,289,102 - 6,289,162EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000024771 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021840 UniProtKB/TrEMBL
  ENSCAFG00845016458 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000038275.4 UniProtKB/TrEMBL
  ENSCAFT00030040041.1 UniProtKB/TrEMBL
  ENSCAFT00845029185 ENTREZGENE
  ENSCAFT00845029185.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene KLF14 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 14 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8C0LDE5 ENTREZGENE
  A0A8C0P030 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NZV2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:42433 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-11 KLF14  KLF transcription factor 14  KLF14  Kruppel like factor 14  Symbol and/or name change 19259463 PROVISIONAL