RPA3 (replication protein A3) - Rat Genome Database

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Gene: RPA3 (replication protein A3) Canis lupus familiaris
Analyze
Symbol: RPA3
Name: replication protein A3
RGD ID: 12156781
Description: ENCODES a protein that exhibits damaged DNA binding (inferred); DNA binding (inferred); single-stranded DNA binding (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); regulation of mitotic cell cycle (ortholog); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; FOUND IN DNA replication factor A complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: replication protein A 14 kDa subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11423,230,447 - 23,234,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,893,352 - 2,893,717 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,805,480 - 22,809,588 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01423,045,005 - 23,049,117 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11423,197,309 - 23,201,240 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01422,930,101 - 22,934,209 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01423,187,728 - 23,191,835 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RPA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11423,230,447 - 23,234,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl112,893,352 - 2,893,717 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1422,805,480 - 22,809,588 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01423,045,005 - 23,049,117 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11423,197,309 - 23,201,240 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01422,930,101 - 22,934,209 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01423,187,728 - 23,191,835 (-)NCBIUU_Cfam_GSD_1.0
RPA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3877,636,518 - 7,718,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl77,636,518 - 7,718,607 (-)EnsemblGRCh38hg38GRCh38
GRCh3777,676,149 - 7,758,238 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3677,643,100 - 7,724,763 (-)NCBINCBI36Build 36hg18NCBI36
Build 3477,449,816 - 7,531,478NCBI
Celera77,644,982 - 7,725,987 (-)NCBICelera
Cytogenetic Map7p21.3NCBI
HuRef77,525,171 - 7,607,577 (-)NCBIHuRef
CHM1_177,676,293 - 7,757,838 (-)NCBICHM1_1
T2T-CHM13v2.077,754,317 - 7,837,139 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v277,723,782 - 7,804,410 (-)NCBI
Rpa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3968,255,936 - 8,259,141 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl68,255,936 - 8,259,173 (-)EnsemblGRCm39 Ensembl
GRCm3868,255,936 - 8,259,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl68,255,936 - 8,259,173 (-)EnsemblGRCm38mm10GRCm38
MGSCv3768,205,936 - 8,209,141 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3668,205,937 - 8,209,113 (-)NCBIMGSCv36mm8
Celera68,397,638 - 8,400,833 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map63.53NCBI
Rpa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8437,270,966 - 37,273,997 (-)NCBIGRCr8
mRatBN7.2436,304,649 - 36,307,755 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl436,304,651 - 36,307,709 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx441,272,230 - 41,275,262 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0437,198,431 - 37,201,463 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0435,609,727 - 35,612,758 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0434,279,320 - 34,282,351 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl434,279,320 - 34,282,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0434,139,498 - 34,142,529 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4433,304,334 - 33,307,365 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1433,422,871 - 33,425,905 (-)NCBI
Celera431,808,230 - 31,811,261 (-)NCBICelera
Cytogenetic Map4q21NCBI
Rpa3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543214,723,751 - 14,727,290 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543214,723,933 - 14,727,356 (-)NCBIChiLan1.0ChiLan1.0
RPA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2612,536,575 - 12,540,340 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1760,861,290 - 60,864,770 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v078,361,623 - 8,365,098 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.177,713,632 - 7,794,199 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl77,713,629 - 7,717,169 (-)Ensemblpanpan1.1panPan2
Rpa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511836,592,667 - 36,596,130 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365852,266,706 - 2,272,259 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365852,267,113 - 2,270,635 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl977,910,881 - 77,937,060 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1977,910,876 - 77,914,872 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RPA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12150,570,027 - 50,574,270 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2150,570,751 - 50,574,216 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604253,812,402 - 53,816,643 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rpa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248135,247,033 - 5,253,413 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248135,248,794 - 5,252,264 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RPA3
39 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 2 19 4 6 4 5 11 6 9 5
Below cutoff 3 3 2 2 1 2 1 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000000410   ⟹   ENSCAFP00000000375
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl112,893,352 - 2,893,717 (-)Ensembl
RefSeq Acc Id: XM_038494639   ⟹   XP_038350567
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11423,197,309 - 23,201,240 (-)NCBI
RefSeq Acc Id: XM_038556921   ⟹   XP_038412849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01423,187,728 - 23,191,835 (-)NCBI
RefSeq Acc Id: XM_038620858   ⟹   XP_038476786
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01422,930,101 - 22,934,209 (-)NCBI
RefSeq Acc Id: XM_038686549   ⟹   XP_038542477
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01423,045,005 - 23,049,117 (-)NCBI
RefSeq Acc Id: XM_538570   ⟹   XP_538570
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11423,230,447 - 23,234,554 (-)NCBI
Dog10K_Boxer_Tasha1422,805,480 - 22,809,588 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_538570   ⟸   XM_538570
- UniProtKB: A0A8C0SS84 (UniProtKB/TrEMBL),   A0A8C0KC50 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000000375   ⟸   ENSCAFT00000000410
RefSeq Acc Id: XP_038350567   ⟸   XM_038494639
RefSeq Acc Id: XP_038476786   ⟸   XM_038620858
RefSeq Acc Id: XP_038542477   ⟸   XM_038686549
- UniProtKB: A0A8C0SS84 (UniProtKB/TrEMBL),   A0A8C0KC50 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038412849   ⟸   XM_038556921
- UniProtKB: A0A8C0KC50 (UniProtKB/TrEMBL),   A0A8C0SS84 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000261 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00000049566 UniProtKB/TrEMBL
  ENSCAFG00030005335 UniProtKB/TrEMBL
  ENSCAFG00030016731 UniProtKB/TrEMBL
  ENSCAFG00040009943 UniProtKB/TrEMBL
  ENSCAFG00040015889 UniProtKB/TrEMBL
  ENSCAFG00845023019 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000410.5 UniProtKB/TrEMBL
  ENSCAFT00000107178.1 UniProtKB/TrEMBL
  ENSCAFT00030009774.1 UniProtKB/TrEMBL
  ENSCAFT00030030873.1 UniProtKB/TrEMBL
  ENSCAFT00040018415.1 UniProtKB/TrEMBL
  ENSCAFT00040029267.1 UniProtKB/TrEMBL
  ENSCAFT00845040634.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  Rfa2 UniProtKB/TrEMBL
KEGG Report cfa:481449 UniProtKB/TrEMBL
NCBI Gene RPA3 ENTREZGENE
PANTHER REPLICATION PROTEIN A 14 KDA SUBUNIT UniProtKB/TrEMBL
  REPLICATION PROTEIN A3 UniProtKB/TrEMBL
Pfam Rep_fac-A_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
UniProt A0A8C0KC50 ENTREZGENE
  A0A8C0S596_CANLF UniProtKB/TrEMBL
  A0A8C0SS84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PQZ7_CANLF UniProtKB/TrEMBL
  A0A8P0TUV8_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45704 ENTREZGENE