S1PR3 (sphingosine-1-phosphate receptor 3) - Rat Genome Database

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Gene: S1PR3 (sphingosine-1-phosphate receptor 3) Canis lupus familiaris
Analyze
Symbol: S1PR3
Name: sphingosine-1-phosphate receptor 3
RGD ID: 12128577
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); integrin binding (inferred); sphingosine-1-phosphate receptor activity (inferred); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); inflammatory response (ortholog); Notch signaling pathway (ortholog); PARTICIPATES IN sphingosine 1-phosphate signaling pathway; FOUND IN presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: EDG3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; sphingosine 1-phosphate receptor 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1197,102,708 - 97,107,611 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl197,104,652 - 97,105,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha197,565,504 - 97,576,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0197,714,499 - 97,725,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl197,714,526 - 97,725,557 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1197,342,250 - 97,353,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0197,061,323 - 97,072,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0197,819,845 - 97,830,838 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
S1PR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1197,102,708 - 97,107,611 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl197,104,652 - 97,105,857 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha197,565,504 - 97,576,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0197,714,499 - 97,725,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl197,714,526 - 97,725,557 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1197,342,250 - 97,353,244 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0197,061,323 - 97,072,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0197,819,845 - 97,830,838 (-)NCBIUU_Cfam_GSD_1.0
S1PR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38988,990,863 - 89,005,155 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl988,990,863 - 89,005,155 (+)EnsemblGRCh38hg38GRCh38
GRCh37991,605,778 - 91,620,070 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36990,796,182 - 90,809,745 (+)NCBINCBI36Build 36hg18NCBI36
Build 34988,835,915 - 88,849,478NCBI
Celera962,189,011 - 62,202,574 (+)NCBICelera
Cytogenetic Map9q22.1NCBI
HuRef961,438,768 - 61,452,511 (+)NCBIHuRef
CHM1_1991,754,483 - 91,768,224 (+)NCBICHM1_1
T2T-CHM13v2.09101,153,351 - 101,167,644 (+)NCBIT2T-CHM13v2.0
S1pr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391351,562,654 - 51,576,833 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1351,562,675 - 51,576,833 (+)EnsemblGRCm39 Ensembl
GRCm381351,408,618 - 51,422,797 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1351,408,639 - 51,422,797 (+)EnsemblGRCm38mm10GRCm38
MGSCv371351,503,987 - 51,518,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361351,421,260 - 51,435,293 (+)NCBIMGSCv36mm8
Celera1352,481,303 - 52,495,482 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1326.12NCBI
S1pr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81713,932,773 - 13,946,213 (-)NCBIGRCr8
mRatBN7.21713,781,050 - 13,794,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1713,781,050 - 13,794,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1713,704,546 - 13,717,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01715,315,258 - 15,328,555 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01713,631,365 - 13,644,660 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01713,799,383 - 13,812,877 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1713,799,383 - 13,812,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01715,871,251 - 15,884,751 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41719,657,822 - 19,661,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1713,529,246 - 13,542,351 (-)NCBICelera
Cytogenetic Map17p14NCBI
S1pr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555153,024,258 - 3,035,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555153,024,258 - 3,035,996 (-)NCBIChiLan1.0ChiLan1.0
S1PR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21150,455,855 - 50,460,900 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1950,459,337 - 50,463,288 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0960,080,189 - 60,094,311 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1988,126,416 - 88,140,149 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl988,126,476 - 88,137,333 (+)Ensemblpanpan1.1panPan2
S1pr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494410,793,383 - 10,849,904 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493764539,701 - 42,497 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493764539,690 - 40,790 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S1PR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14659,309 - 671,706 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114659,314 - 674,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214880,158 - 898,709 (+)NCBISscrofa10.2Sscrofa10.2susScr3
S1PR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11299,484,615 - 99,498,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1299,494,423 - 99,495,559 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603887,806,079 - 87,819,666 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
S1pr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476523,659,973 - 23,673,809 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476523,660,155 - 23,673,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in S1PR3
52 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 5
Low 3 5 19 6 6 6 6 12 2 6
Below cutoff 3 6 8 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003462   ⟹   ENSCAFP00000003210
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl197,104,652 - 97,105,857 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845035498   ⟹   ENSCAFP00845027776
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl197,714,526 - 97,725,557 (-)Ensembl
RefSeq Acc Id: XM_038466620   ⟹   XP_038322548
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1197,342,250 - 97,353,244 (-)NCBI
RefSeq Acc Id: XM_038527326   ⟹   XP_038383254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0197,819,845 - 97,830,838 (-)NCBI
RefSeq Acc Id: XM_038591631   ⟹   XP_038447559
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0197,061,323 - 97,072,318 (-)NCBI
RefSeq Acc Id: XM_038607228   ⟹   XP_038463156
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha197,565,504 - 97,576,501 (-)NCBI
RefSeq Acc Id: XM_038655422   ⟹   XP_038511350
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0197,714,499 - 97,725,495 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000003210   ⟸   ENSCAFT00000003462
RefSeq Acc Id: XP_038322548   ⟸   XM_038466620
RefSeq Acc Id: XP_038447559   ⟸   XM_038591631
RefSeq Acc Id: XP_038511350   ⟸   XM_038655422
- UniProtKB: A0A8C0K3D5 (UniProtKB/TrEMBL),   A0A8C0M481 (UniProtKB/TrEMBL),   A0A8I3P7L3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038463156   ⟸   XM_038607228
- UniProtKB: A0A8C0PQB6 (UniProtKB/TrEMBL),   A0A8P0N5B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038383254   ⟸   XM_038527326
- UniProtKB: A0A8C0K3D5 (UniProtKB/TrEMBL),   A0A8C0M481 (UniProtKB/TrEMBL),   A0A8I3P7L3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845027776   ⟸   ENSCAFT00845035498
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002204 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030002714 UniProtKB/TrEMBL
  ENSCAFG00040000450 UniProtKB/TrEMBL
  ENSCAFG00845020161 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003462.4 UniProtKB/TrEMBL
  ENSCAFT00030005029.1 UniProtKB/TrEMBL
  ENSCAFT00040000762.1 UniProtKB/TrEMBL
  ENSCAFT00845035498 ENTREZGENE
  ENSCAFT00845035498.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro EDG3_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  S1P_rcpt UniProtKB/TrEMBL
NCBI Gene S1PR3 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  SPHINGOSINE 1-PHOSPHATE RECEPTOR 3 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS EDG3RECEPTOR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
  S1PRECEPTOR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8C0K3D5 ENTREZGENE
  A0A8C0M481 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PQB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P7L3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N5B1 ENTREZGENE
UniProt Secondary A0A8P0N5B1 UniProtKB/TrEMBL
VGNC ID VGNC:45837 ENTREZGENE