EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma) - Rat Genome Database

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Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma) Canis lupus familiaris
Analyze
Symbol: EIF2B3
Name: eukaryotic translation initiation factor 2B subunit gamma
RGD ID: 12123812
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); translation factor activity, RNA binding (ortholog); translation initiation factor activity (ortholog); INVOLVED IN hippocampus development (ortholog); oligodendrocyte development (ortholog); response to glucose (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN cytoplasm (ortholog); eukaryotic translation initiation factor 2B complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: translation initiation factor eIF-2B subunit gamma
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11515,337,421 - 15,481,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1515,337,483 - 15,481,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1515,458,142 - 15,601,622 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01515,492,735 - 15,636,800 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1515,492,756 - 15,636,794 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11515,289,691 - 15,433,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01515,357,619 - 15,501,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01515,429,796 - 15,574,243 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EIF2B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11515,337,421 - 15,481,427 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1515,337,483 - 15,481,425 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1515,458,142 - 15,601,622 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01515,492,735 - 15,636,800 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1515,492,756 - 15,636,794 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11515,289,691 - 15,433,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01515,357,619 - 15,501,550 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01515,429,796 - 15,574,243 (+)NCBIUU_Cfam_GSD_1.0
EIF2B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38144,850,522 - 44,986,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl144,850,522 - 44,986,722 (-)EnsemblGRCh38hg38GRCh38
GRCh37145,316,194 - 45,452,267 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,089,037 - 45,224,869 (-)NCBINCBI36Build 36hg18NCBI36
Build 34144,985,606 - 45,121,349NCBI
Celera143,598,935 - 43,735,148 (-)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef143,428,607 - 43,564,682 (-)NCBIHuRef
CHM1_1145,432,292 - 45,568,970 (-)NCBICHM1_1
T2T-CHM13v2.0144,721,756 - 44,858,197 (-)NCBIT2T-CHM13v2.0
Eif2b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,876,559 - 116,944,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,876,599 - 116,944,503 (+)EnsemblGRCm39 Ensembl
GRCm384117,019,399 - 117,086,852 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4117,019,402 - 117,087,306 (+)EnsemblGRCm38mm10GRCm38
MGSCv374116,692,013 - 116,759,457 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,517,334 - 116,585,238 (+)NCBIMGSCv36mm8
Celera4115,754,605 - 115,822,241 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.41NCBI
Eif2b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,728,764 - 135,795,276 (+)NCBIGRCr8
mRatBN7.25130,492,167 - 130,558,692 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,492,220 - 130,563,332 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5133,123,091 - 133,188,111 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,877,699 - 134,942,722 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,900,110 - 134,965,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,882,946 - 135,949,276 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,882,967 - 135,949,818 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,677,822 - 139,744,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45137,323,754 - 137,398,327 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15137,328,979 - 137,403,552 (+)NCBI
Celera5129,018,586 - 129,084,980 (+)NCBICelera
Cytogenetic Map5q36NCBI
Eif2b3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546413,254,228 - 13,378,832 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546413,254,228 - 13,378,832 (+)NCBIChiLan1.0ChiLan1.0
EIF2B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,821,005 - 181,956,859 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,962,564 - 181,098,380 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,154,600 - 44,290,407 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1145,520,587 - 45,655,424 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl145,525,137 - 45,650,259 (-)Ensemblpanpan1.1panPan2
Eif2b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,250,716 - 60,362,626 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,075,204 - 26,187,459 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,075,503 - 26,187,459 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6166,353,934 - 166,494,698 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16166,353,918 - 166,487,581 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,765,212 - 153,900,676 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,800,695 - 87,945,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,800,670 - 87,945,569 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603328,995,636 - 29,143,641 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2b3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624906733,146 - 892,362 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624906733,148 - 882,690 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EIF2B3
1593 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 15 5 6 5 12 8 10 6
Low 1 7 6 1 6 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000007530   ⟹   ENSCAFP00000006972
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1515,337,483 - 15,481,425 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000071940   ⟹   ENSCAFP00000045407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1515,337,483 - 15,481,248 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044572   ⟹   ENSCAFP00845034919
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1515,492,756 - 15,636,616 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044654   ⟹   ENSCAFP00845034988
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1515,492,756 - 15,623,579 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044753   ⟹   ENSCAFP00845035068
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1515,492,780 - 15,636,794 (+)Ensembl
RefSeq Acc Id: XM_038495877   ⟹   XP_038351805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11515,289,691 - 15,433,641 (+)NCBI
RefSeq Acc Id: XM_038558254   ⟹   XP_038414182
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01515,429,796 - 15,574,243 (+)NCBI
RefSeq Acc Id: XM_038622137   ⟹   XP_038478065
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01515,357,619 - 15,501,550 (+)NCBI
RefSeq Acc Id: XM_038687875   ⟹   XP_038543803
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01515,492,735 - 15,636,800 (+)NCBI
RefSeq Acc Id: XM_532603   ⟹   XP_532603
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11515,337,421 - 15,481,427 (+)NCBI
Dog10K_Boxer_Tasha1515,458,142 - 15,601,622 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_532603   ⟸   XM_532603
- UniProtKB: A0A8C0T4V7 (UniProtKB/TrEMBL),   A0A8P0N7H6 (UniProtKB/TrEMBL),   A0A8P0PJN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000045407   ⟸   ENSCAFT00000071940
RefSeq Acc Id: ENSCAFP00000006972   ⟸   ENSCAFT00000007530
RefSeq Acc Id: XP_038351805   ⟸   XM_038495877
RefSeq Acc Id: XP_038478065   ⟸   XM_038622137
RefSeq Acc Id: XP_038543803   ⟸   XM_038687875
- UniProtKB: A0A8I3PXU7 (UniProtKB/TrEMBL),   A0A8I3PPG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414182   ⟸   XM_038558254
- UniProtKB: A0A8C0T4V7 (UniProtKB/TrEMBL),   A0A8P0N7H6 (UniProtKB/TrEMBL),   A0A8P0PJN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845034919   ⟸   ENSCAFT00845044572
RefSeq Acc Id: ENSCAFP00845034988   ⟸   ENSCAFT00845044654
RefSeq Acc Id: ENSCAFP00845035068   ⟸   ENSCAFT00845044753
Protein Domains
Nucleotidyl transferase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004681 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015812 UniProtKB/TrEMBL
  ENSCAFG00040019246 UniProtKB/TrEMBL
  ENSCAFG00845025255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000007530.5 UniProtKB/TrEMBL
  ENSCAFT00000071940.2 UniProtKB/TrEMBL
  ENSCAFT00000094557.1 UniProtKB/TrEMBL
  ENSCAFT00030029135.1 UniProtKB/TrEMBL
  ENSCAFT00030029193.1 UniProtKB/TrEMBL
  ENSCAFT00040035620.1 UniProtKB/TrEMBL
  ENSCAFT00040035664.1 UniProtKB/TrEMBL
  ENSCAFT00845044572.1 UniProtKB/TrEMBL
  ENSCAFT00845044654.1 UniProtKB/TrEMBL
  ENSCAFT00845044753 ENTREZGENE
  ENSCAFT00845044753.1 UniProtKB/TrEMBL
Gene3D-CATH Hexapeptide repeat proteins UniProtKB/TrEMBL
InterPro NTP_transferase_dom UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/TrEMBL
NCBI Gene EIF2B3 ENTREZGENE
PANTHER TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA UniProtKB/TrEMBL
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA UniProtKB/TrEMBL
Pfam NTP_transferase UniProtKB/TrEMBL
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A0A8C0NDH5_CANLF UniProtKB/TrEMBL
  A0A8C0T4V7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PPG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PTS6_CANLF UniProtKB/TrEMBL
  A0A8I3PXU7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N7H6 ENTREZGENE
  A0A8P0PJN9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0N7H6 UniProtKB/TrEMBL
  A0A8P0SYJ6 UniProtKB/TrEMBL
VGNC ID VGNC:40262 ENTREZGENE