MSL1 (MSL complex subunit 1) - Rat Genome Database

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Gene: MSL1 (MSL complex subunit 1) Canis lupus familiaris
Analyze
Symbol: MSL1
Name: MSL complex subunit 1
RGD ID: 12069810
Description: ENCODES a protein that exhibits protein-macromolecule adaptor activity (ortholog); INVOLVED IN chromatin remodeling (inferred); positive regulation of DNA-templated transcription (inferred); ASSOCIATED WITH hypertrophic cardiomyopathy 25 (ortholog); FOUND IN MSL complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: male specific lethal 1 homolog; male-specific lethal 1 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,429,371 - 22,441,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,429,522 - 22,441,767 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,901,643 - 21,913,922 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,222,191 - 23,234,472 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,222,204 - 23,234,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,995,939 - 22,008,217 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,254,672 - 22,266,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,379,645 - 22,391,924 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
MSL complex  (IEA,ISO)
nuclear speck  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MSL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,429,371 - 22,441,686 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,429,522 - 22,441,767 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,901,643 - 21,913,922 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,222,191 - 23,234,472 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,222,204 - 23,234,365 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,995,939 - 22,008,217 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,254,672 - 22,266,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,379,645 - 22,391,924 (-)NCBIUU_Cfam_GSD_1.0
MSL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,121,971 - 40,136,917 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,121,971 - 40,136,917 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,278,224 - 38,293,170 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,532,316 - 35,546,568 (+)NCBINCBI36Build 36hg18NCBI36
Celera1734,939,245 - 34,953,515 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1734,072,418 - 34,086,448 (+)NCBIHuRef
CHM1_11738,514,496 - 38,528,748 (+)NCBICHM1_1
T2T-CHM13v2.01740,985,855 - 41,000,801 (+)NCBIT2T-CHM13v2.0
Msl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,684,214 - 98,698,685 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,686,342 - 98,698,685 (+)EnsemblGRCm39 Ensembl
GRCm381198,793,508 - 98,807,862 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,795,516 - 98,807,859 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,657,083 - 98,669,173 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,611,606 - 98,622,517 (+)NCBIMGSCv36mm8
Celera11108,450,534 - 108,462,629 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.67NCBI
Msl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,251,362 - 84,263,384 (+)NCBIGRCr8
mRatBN7.21083,755,380 - 83,767,147 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,755,720 - 83,765,726 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,699,593 - 88,709,611 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,197,668 - 88,207,686 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01083,590,370 - 83,600,388 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01086,710,925 - 86,722,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,711,240 - 86,721,246 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,507,409 - 86,518,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,568,556 - 87,578,572 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1082,503,569 - 82,513,585 (+)NCBICelera
Cytogenetic Map10q31NCBI
Msl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,772,224 - 14,780,839 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,769,893 - 14,783,213 (+)NCBIChiLan1.0ChiLan1.0
MSL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,818,118 - 24,833,517 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,712,913 - 26,727,748 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,152,296 - 17,167,127 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,373,780 - 17,387,329 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,373,780 - 17,387,351 (-)Ensemblpanpan1.1panPan2
Msl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,825,478 - 21,839,052 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,236,081 - 15,249,926 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,236,087 - 15,249,661 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,224,615 - 22,237,587 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,224,611 - 22,237,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,502,558 - 22,515,232 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,040,879 - 66,055,975 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,040,661 - 66,055,942 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,944,141 - 36,960,612 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,068,887 - 3,083,751 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,070,233 - 3,083,746 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MSL1
56 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 6 4 12 8 10 6
Low 5 6 6 6 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005624538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005624539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038485632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038547399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038611383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038676576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002629904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005330665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005364396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005398821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005432152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000025622   ⟹   ENSCAFP00000023795
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,429,522 - 22,441,767 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000089324   ⟹   ENSCAFP00000055878
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl922,429,522 - 22,441,767 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017109   ⟹   ENSCAFP00845013326
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,222,204 - 23,234,365 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845017151   ⟹   ENSCAFP00845013362
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl923,222,204 - 23,234,365 (-)Ensembl
RefSeq Acc Id: XM_005624538   ⟹   XP_005624595
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,429,371 - 22,441,686 (-)NCBI
Dog10K_Boxer_Tasha921,901,643 - 21,913,919 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005624539   ⟹   XP_005624596
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,429,379 - 22,441,651 (-)NCBI
Dog10K_Boxer_Tasha921,901,643 - 21,913,921 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038485631   ⟹   XP_038341559
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1921,995,939 - 22,008,214 (-)NCBI
RefSeq Acc Id: XM_038485632   ⟹   XP_038341560
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1921,995,939 - 22,008,216 (-)NCBI
RefSeq Acc Id: XM_038547398   ⟹   XP_038403326
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0922,379,645 - 22,391,921 (-)NCBI
RefSeq Acc Id: XM_038547399   ⟹   XP_038403327
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0922,379,645 - 22,391,923 (-)NCBI
RefSeq Acc Id: XM_038611382   ⟹   XP_038467310
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0922,254,672 - 22,266,940 (-)NCBI
RefSeq Acc Id: XM_038611383   ⟹   XP_038467311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0922,254,672 - 22,266,942 (-)NCBI
RefSeq Acc Id: XM_038676575   ⟹   XP_038532503
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0923,222,191 - 23,234,469 (-)NCBI
RefSeq Acc Id: XM_038676576   ⟹   XP_038532504
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0923,222,191 - 23,234,471 (-)NCBI
RefSeq Acc Id: XR_002629904
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1922,431,889 - 22,441,653 (-)NCBI
Dog10K_Boxer_Tasha921,904,109 - 21,913,922 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005330665
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1921,998,403 - 22,008,217 (-)NCBI
RefSeq Acc Id: XR_005364396
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0922,382,109 - 22,391,924 (-)NCBI
RefSeq Acc Id: XR_005398821
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0922,257,136 - 22,266,943 (-)NCBI
RefSeq Acc Id: XR_005432152
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0923,224,655 - 23,234,472 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005624596   ⟸   XM_005624539
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PV85 (UniProtKB/TrEMBL),   A0A8I3NDZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005624595   ⟸   XM_005624538
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NJA9 (UniProtKB/TrEMBL),   A0A8I3NDW9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000023795   ⟸   ENSCAFT00000025622
RefSeq Acc Id: ENSCAFP00000055878   ⟸   ENSCAFT00000089324
RefSeq Acc Id: XP_038341560   ⟸   XM_038485632
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038341559   ⟸   XM_038485631
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038467311   ⟸   XM_038611383
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038467310   ⟸   XM_038611382
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038532504   ⟸   XM_038676576
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PV85 (UniProtKB/TrEMBL),   A0A8I3NDZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038532503   ⟸   XM_038676575
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NJA9 (UniProtKB/TrEMBL),   A0A8I3NDW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403327   ⟸   XM_038547399
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PV85 (UniProtKB/TrEMBL),   A0A8I3NDZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038403326   ⟸   XM_038547398
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NJA9 (UniProtKB/TrEMBL),   A0A8I3NDW9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845013362   ⟸   ENSCAFT00845017151
RefSeq Acc Id: ENSCAFP00845013326   ⟸   ENSCAFT00845017109
Protein Domains
PEHE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016146 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014465 UniProtKB/TrEMBL
  ENSCAFG00040000553 UniProtKB/TrEMBL
  ENSCAFG00845009660 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025622.5 UniProtKB/TrEMBL
  ENSCAFT00000089324.2 UniProtKB/TrEMBL
  ENSCAFT00030026747.1 UniProtKB/TrEMBL
  ENSCAFT00030026830.1 UniProtKB/TrEMBL
  ENSCAFT00040001099.1 UniProtKB/TrEMBL
  ENSCAFT00040001114.1 UniProtKB/TrEMBL
  ENSCAFT00845017109 ENTREZGENE
  ENSCAFT00845017109.1 UniProtKB/TrEMBL
  ENSCAFT00845017151 ENTREZGENE
  ENSCAFT00845017151.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  6.10.250.2000 UniProtKB/TrEMBL
InterPro Msl-1 UniProtKB/TrEMBL
  MSL1_dimer UniProtKB/TrEMBL
  PEHE_dom UniProtKB/TrEMBL
KEGG Report cfa:100688164 UniProtKB/TrEMBL
NCBI Gene MSL1 ENTREZGENE
PANTHER MALE-SPECIFIC LETHAL 1 HOMOLOG UniProtKB/TrEMBL
  PTHR21656 UniProtKB/TrEMBL
Pfam MSL1_dimer UniProtKB/TrEMBL
  PEHE UniProtKB/TrEMBL
SMART PEHE UniProtKB/TrEMBL
UniProt A0A8C0NJA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0PV85 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NDW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NDZ6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43443 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-22 MSL1  MSL complex subunit 1    male specific lethal 1 homolog  Symbol and/or name change 5135510 APPROVED