LCN2 (lipocalin 2) - Rat Genome Database

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Gene: LCN2 (lipocalin 2) Pan paniscus
Analyze
Symbol: LCN2
Name: lipocalin 2
RGD ID: 11908284
Description: ENCODES a protein that exhibits enterobactin binding (ortholog); identical protein binding (ortholog); protease binding (ortholog); INVOLVED IN acute-phase response (ortholog); cellular response to amyloid-beta (ortholog); cellular response to hydrogen peroxide (ortholog); ASSOCIATED WITH Abscess (ortholog); acute cystitis (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neutrophil gelatinase-associated lipocalin
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,199,073 - 11,214,309 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,201,421 - 11,216,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,940,799 - 127,944,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abscess  (ISO)
acute cystitis  (ISO)
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Hepatitis  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
beta thalassemia  (ISO)
calcinosis  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chlamydophila Infections  (ISO)
chronic kidney disease  (ISO)
colon cancer  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Iu  (ISO)
contact dermatitis  (ISO)
Contrast-Induced Nephropathy  (ISO)
COVID-19  (ISO)
developmental and epileptic encephalopathy  (ISO)
developmental and epileptic encephalopathy 31A  (ISO)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
early infantile epileptic encephalopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Escherichia Coli Infections  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Radiation Injuries  (ISO)
Haemophilus Infections  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
hidradenitis suppurativa  (ISO)
hydronephrosis  (ISO)
hyperuricemia  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Klebsiella pneumonia  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oral candidiasis  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
primary coenzyme Q10 deficiency 7  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
renal fibrosis  (ISO)
Renal Ischemia  (ISO)
renovascular hypertension  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Streptococcal Infections  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
uveitis  (ISO)
West Nile encephalitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to increased oxygen levels  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to X-ray  (ISO)
defense response to bacterium  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
innate immune response  (ISO)
long-term memory  (ISO)
negative regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell projection organization  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of iron ion import across plasma membrane  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
response to bacterium  (ISO)
response to blue light  (ISO)
response to fructose  (ISO)
response to herbicide  (ISO)
response to iron(II) ion  (ISO)
response to kainic acid  (ISO)
response to lipopolysaccharide  (ISO)
response to mycotoxin  (ISO)
response to nutrient levels  (ISO)
response to oxidative stress  (ISO)
response to toxic substance  (ISO)
response to virus  (ISO)
response to xenobiotic stimulus  (ISO)
short-term memory  (ISO)
siderophore transport  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,199,073 - 11,214,309 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,201,421 - 11,216,652 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,940,799 - 127,944,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)Ensemblpanpan1.1panPan2
LCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,149,453 - 128,153,453 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,149,071 - 128,153,453 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,911,732 - 130,915,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,951,553 - 129,955,555 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,991,271 - 127,995,288NCBI
Celera9101,562,624 - 101,566,626 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,525,402 - 100,529,404 (+)NCBIHuRef
CHM1_19131,062,742 - 131,066,744 (+)NCBICHM1_1
T2T-CHM13v2.09140,356,542 - 140,360,542 (+)NCBIT2T-CHM13v2.0
Lcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,274,649 - 32,277,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,274,645 - 32,278,264 (-)EnsemblGRCm39 Ensembl
GRCm38232,384,637 - 32,387,739 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,384,633 - 32,388,252 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,240,157 - 32,243,259 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,206,646 - 32,209,748 (-)NCBIMGSCv36mm8
Celera232,090,046 - 32,093,150 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Lcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,078,432 - 36,081,851 (-)NCBIGRCr8
mRatBN7.2315,680,688 - 15,684,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,680,687 - 15,684,095 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,749,510 - 18,752,856 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,334,505 - 27,337,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,585,359 - 25,588,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,414,189 - 11,417,534 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,414,186 - 11,417,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,763,059 - 16,766,404 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,511,402 - 11,514,747 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,407,773 - 11,411,119 (-)NCBI
Celera310,423,569 - 10,426,914 (-)NCBICelera
Cytogenetic Map3p12NCBI
LCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,328,118 - 55,342,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,328,133 - 55,332,038 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,522,898 - 54,537,231 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,250,316 - 56,264,670 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,250,331 - 56,254,237 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,010,191 - 55,024,522 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,324,906 - 55,339,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,416,588 - 55,430,934 (-)NCBIUU_Cfam_GSD_1.0
Lcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,953,204 - 195,956,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,721,684 - 15,728,221 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,721,752 - 15,725,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,609,887 - 268,614,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,609,975 - 268,614,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,600,679 - 302,609,836 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,976,278 - 9,981,087 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,976,614 - 9,980,870 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,251,600 - 6,256,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000029753   ⟹   ENSPPAP00000007412
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl9127,940,799 - 127,944,798 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000029756   ⟹   ENSPPAP00000007415
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl9127,940,893 - 127,944,462 (+)Ensembl
RefSeq Acc Id: XM_034929144   ⟹   XP_034785035
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21111,199,073 - 11,213,210 (-)NCBI
NHGRI_mPanPan1911,201,421 - 11,215,558 (-)NCBI
Mhudiblu_PPA_v0999,260,371 - 99,274,494 (+)NCBI
RefSeq Acc Id: XM_034929145   ⟹   XP_034785036
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21111,199,073 - 11,206,807 (-)NCBI
NHGRI_mPanPan1911,201,421 - 11,209,155 (-)NCBI
Mhudiblu_PPA_v0999,266,762 - 99,274,494 (+)NCBI
RefSeq Acc Id: XM_034929146   ⟹   XP_034785037
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21111,199,073 - 11,214,309 (-)NCBI
NHGRI_mPanPan1911,201,421 - 11,216,652 (-)NCBI
Mhudiblu_PPA_v0999,259,278 - 99,274,494 (+)NCBI
RefSeq Acc Id: XM_055117208   ⟹   XP_054973183
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21111,199,073 - 11,211,996 (-)NCBI
NHGRI_mPanPan1911,201,421 - 11,213,374 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034785035 (Get FASTA)   NCBI Sequence Viewer  
  XP_034785036 (Get FASTA)   NCBI Sequence Viewer  
  XP_034785037 (Get FASTA)   NCBI Sequence Viewer  
  XP_054973183 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000007412.1
  ENSPPAP00000007415.1
Reference Protein Sequences
RefSeq Acc Id: XP_034785037   ⟸   XM_034929146
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZR17 (UniProtKB/TrEMBL),   A0A2R8ZWW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034785035   ⟸   XM_034929144
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034785036   ⟸   XM_034929145
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZWW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000007412   ⟸   ENSPPAT00000029753
RefSeq Acc Id: ENSPPAP00000007415   ⟸   ENSPPAT00000029756
RefSeq Acc Id: XP_054973183   ⟸   XM_055117208
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZR17 (UniProtKB/TrEMBL)
Protein Domains
Lipocalin/cytosolic fatty-acid binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000026663 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000029753.1 UniProtKB/TrEMBL
  ENSPPAT00000029756.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  LCN2/LCN12 UniProtKB/TrEMBL
  Lipocalin UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
KEGG Report pps:100971031 UniProtKB/TrEMBL
NCBI Gene LCN2 ENTREZGENE
PANTHER NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN UniProtKB/TrEMBL
  PTHR11430 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PRINTS LIPOCALIN UniProtKB/TrEMBL
  NGELATINASE UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/TrEMBL
UniProt A0A2R8ZR17 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZWW2 ENTREZGENE, UniProtKB/TrEMBL