MYO5B (myosin VB) - Rat Genome Database

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Gene: MYO5B (myosin VB) Pan paniscus
Analyze
Symbol: MYO5B
Name: myosin VB
RGD ID: 11825349
Description: ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); ionotropic glutamate receptor binding (ortholog); small GTPase binding (ortholog); INVOLVED IN cellular response to glycine (ortholog); dendritic spine morphogenesis (ortholog); modulation of chemical synaptic transmission (ortholog); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH amphetamine abuse (ortholog); diarrhea (ortholog); genetic disease (ortholog); FOUND IN brush border (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: unconventional myosin-Vb
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21767,353,649 - 67,723,298 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11853,046,252 - 53,415,901 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01843,207,387 - 43,575,951 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11846,551,603 - 46,783,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1846,555,259 - 46,786,223 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MYO5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21767,353,649 - 67,723,298 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11853,046,252 - 53,415,901 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01843,207,387 - 43,575,951 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11846,551,603 - 46,783,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1846,555,259 - 46,786,223 (-)Ensemblpanpan1.1panPan2
MYO5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381849,822,789 - 50,195,147 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1849,822,789 - 50,195,164 (-)EnsemblGRCh38hg38GRCh38
GRCh371847,349,159 - 47,721,517 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361845,603,099 - 45,975,382 (-)NCBINCBI36Build 36hg18NCBI36
Build 341845,603,183 - 45,975,176NCBI
Celera1844,205,823 - 44,578,011 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1844,203,440 - 44,575,850 (-)NCBIHuRef
CHM1_11847,344,771 - 47,717,073 (-)NCBICHM1_1
T2T-CHM13v2.01850,024,565 - 50,396,878 (-)NCBIT2T-CHM13v2.0
Myo5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391874,575,435 - 74,905,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1874,574,007 - 74,904,564 (+)EnsemblGRCm39 Ensembl
GRCm381874,442,364 - 74,772,698 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1874,440,936 - 74,771,493 (+)EnsemblGRCm38mm10GRCm38
MGSCv371874,602,273 - 74,931,131 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361874,567,984 - 74,896,170 (+)NCBIMGSCv36mm8
Celera1875,677,935 - 75,995,786 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1850.7NCBI
Myo5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81870,313,717 - 70,613,918 (+)NCBIGRCr8
mRatBN7.21868,038,759 - 68,341,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,038,759 - 68,338,745 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1870,146,914 - 70,446,818 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,812,463 - 71,116,126 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01868,671,318 - 68,972,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01870,426,865 - 70,729,985 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1870,427,007 - 70,729,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01869,568,169 - 69,869,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41871,381,068 - 71,580,824 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11871,454,267 - 71,654,025 (+)NCBI
Celera1866,217,242 - 66,515,213 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
Myo5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540234,892,652 - 35,143,704 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540234,892,652 - 35,247,431 (-)NCBIChiLan1.0ChiLan1.0
MYO5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1778,671,636 - 79,006,010 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl778,671,616 - 79,006,006 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha778,076,067 - 78,407,834 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0778,734,540 - 79,067,184 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl778,734,614 - 79,067,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1778,448,208 - 78,782,608 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0778,479,066 - 78,811,670 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0778,763,776 - 79,096,706 (+)NCBIUU_Cfam_GSD_1.0
Myo5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494437,781,039 - 37,998,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,932,789 - 13,234,244 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,932,367 - 13,236,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl199,418,449 - 99,810,139 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1199,418,242 - 99,810,934 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21109,021,575 - 109,119,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYO5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11830,759,345 - 31,143,139 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1830,759,764 - 31,143,474 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660504,906,479 - 5,290,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477813,347,705 - 13,740,767 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477813,352,285 - 13,740,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000063206   ⟹   ENSPPAP00000040291
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1846,555,259 - 46,786,223 (-)Ensembl
RefSeq Acc Id: XM_034943673   ⟹   XP_034799564
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21767,353,649 - 67,723,298 (-)NCBI
NHGRI_mPanPan11853,046,252 - 53,415,901 (-)NCBI
Mhudiblu_PPA_v01843,207,387 - 43,575,951 (-)NCBI
RefSeq Acc Id: XM_034943674   ⟹   XP_034799565
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21767,353,649 - 67,723,291 (-)NCBI
NHGRI_mPanPan11853,046,252 - 53,415,894 (-)NCBI
Mhudiblu_PPA_v01843,207,387 - 43,575,889 (-)NCBI
RefSeq Acc Id: XM_055102690   ⟹   XP_054958665
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21767,353,649 - 67,670,378 (-)NCBI
NHGRI_mPanPan11853,046,252 - 53,362,981 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034799564 (Get FASTA)   NCBI Sequence Viewer  
  XP_034799565 (Get FASTA)   NCBI Sequence Viewer  
  XP_054958665 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000040291.1
Reference Protein Sequences
RefSeq Acc Id: XP_034799564   ⟸   XM_034943673
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CEC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034799565   ⟸   XM_034943674
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CEC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000040291   ⟸   ENSPPAT00000063206
RefSeq Acc Id: XP_054958665   ⟸   XM_055102690
- Peptide Label: isoform X3
Protein Domains
Dilute   Myosin motor   Myosin N-terminal SH3-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042788 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063206.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
InterPro Dilute_dom UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myo5b_CBD UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  MYSc_Myo5 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene MYO5B ENTREZGENE
PANTHER MYOSIN UniProtKB/TrEMBL
  MYOSIN MOTOR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam DIL UniProtKB/TrEMBL
  Myosin_head UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE DILUTE UniProtKB/TrEMBL
  MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
SMART DIL UniProtKB/TrEMBL
  MYSc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9CEC0 ENTREZGENE, UniProtKB/TrEMBL