CD40LG (CD40 ligand) - Rat Genome Database

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Gene: CD40LG (CD40 ligand) Pan paniscus
Analyze
Symbol: CD40LG
Name: CD40 ligand
RGD ID: 11708494
Description: ENCODES a protein that exhibits CD40 receptor binding (ortholog); INVOLVED IN B cell differentiation (ortholog); cellular response to tumor necrosis factor (ortholog); dendritic cell differentiation (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; obesity pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Coronary Syndrome (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CD40L
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X136,065,286 - 136,078,025 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X136,068,886 - 136,081,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,776,138 - 125,788,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X136,042,849 - 136,055,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX136,042,849 - 136,058,202 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
Calcification of Aortic Valve  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
CD40 ligand deficiency  (ISO)
Cholangiofibrosis  (ISO)
Christianson syndrome  (ISO)
Chromosome Breakage  (ISO)
Chromosome Xq26.3 Duplication Syndrome  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic lymphocytic leukemia  (ISO)
cocaine abuse  (ISO)
Colonic Neoplasms  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
common variable immunodeficiency  (ISO)
Congenital Heart Defects, Multiple Types, 1, X-Linked  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
crescentic glomerulonephritis  (ISO)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Discoid Lupus Erythematosus  (ISO)
dysgammaglobulinemia  (ISO)
Ehrlich tumor carcinoma  (ISO)
end stage renal disease  (ISO)
eosinophilic esophagitis  (ISO)
erythema multiforme  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
factor VIII deficiency  (ISO)
familial hyperlipidemia  (ISO)
Fibrosis  (ISO)
follicular lymphoma  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
inflammatory bowel disease  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
lichen planus  (ISO)
lupus nephritis  (ISO)
Lyme Neuroborreliosis  (ISO)
malaria  (ISO)
membranous glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
Middle East respiratory syndrome  (ISO)
migraine  (ISO)
multiple myeloma  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
narcolepsy  (ISO)
Necrosis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
ovarian disease  (ISO)
Ovarian Neoplasms  (ISO)
overactive bladder syndrome  (ISO)
pemphigus  (ISO)
Penetrating Wounds  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontal disease  (ISO)
periodontitis  (ISO)
peritonitis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
Primary Graft Dysfunction  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
Sepsis  (ISO)
Shock  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
Subacute Combined Degeneration  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
tick-borne encephalitis  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Vascular Calcification  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
vitamin B12 deficiency  (ISO)
X-linked hyper IgM syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CD40LG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X136,065,286 - 136,078,025 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X136,068,886 - 136,081,625 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X125,776,138 - 125,788,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X136,042,849 - 136,055,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX136,042,849 - 136,058,202 (+)Ensemblpanpan1.1panPan2
CD40LG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,648,158 - 136,660,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX136,648,158 - 136,660,390 (+)EnsemblGRCh38hg38GRCh38
GRCh37X135,730,317 - 135,742,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,558,002 - 135,570,215 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X135,455,855 - 135,468,068NCBI
CeleraX136,094,012 - 136,106,224 (+)NCBICelera
Cytogenetic MapXq26.3NCBI
HuRefX125,001,305 - 125,013,640 (+)NCBIHuRef
CHM1_1X135,641,985 - 135,654,211 (+)NCBICHM1_1
T2T-CHM13v2.0X134,956,900 - 134,969,116 (+)NCBIT2T-CHM13v2.0
Cd40lg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,257,448 - 56,269,402 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)EnsemblGRCm39 Ensembl
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBIMGSCv36mm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
Cd40lg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X140,164,341 - 140,176,057 (+)NCBIGRCr8
mRatBN7.2X135,127,052 - 135,138,768 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX135,126,969 - 135,138,306 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX137,323,952 - 137,335,135 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X140,881,620 - 140,892,805 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X138,451,019 - 138,462,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X159,703,703 - 159,714,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX159,703,578 - 159,716,562 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X154,330,893 - 154,341,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,925,019 - 141,937,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X141,998,451 - 142,010,616 (+)NCBI
CeleraX143,160,596 - 143,171,765 (+)NCBICelera
Cytogenetic MapXq36NCBI
Cd40lg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,465,164 - 8,477,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,465,571 - 8,477,714 (-)NCBIChiLan1.0ChiLan1.0
CD40LG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X107,001,421 - 107,023,007 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX107,010,890 - 107,023,006 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,832,126 - 92,844,241 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X108,980,873 - 109,002,662 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX108,990,551 - 109,002,661 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X106,131,221 - 106,143,392 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X108,322,638 - 108,334,748 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X107,964,432 - 107,976,548 (+)NCBIUU_Cfam_GSD_1.0
Cd40lg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,994,220 - 105,007,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651310,607,617 - 10,620,403 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651310,607,617 - 10,620,403 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD40LG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,778,493 - 111,789,709 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,778,666 - 111,788,901 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,636,797 - 127,647,035 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD40LG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,655,301 - 111,667,602 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX111,655,397 - 111,666,639 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606549,341,810 - 49,354,077 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd40lg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480810,472,572 - 10,484,338 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480810,472,028 - 10,484,407 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000062777   ⟹   ENSPPAP00000039865
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX136,042,849 - 136,058,202 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000062787   ⟹   ENSPPAP00000039875
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX136,043,020 - 136,054,510 (+)Ensembl
RefSeq Acc Id: XM_003812322   ⟹   XP_003812370
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X136,065,286 - 136,078,025 (+)NCBI
NHGRI_mPanPan1X136,068,886 - 136,081,625 (+)NCBI
Mhudiblu_PPA_v0X125,776,138 - 125,788,820 (+)NCBI
PanPan1.1X136,042,849 - 136,055,158 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003812370 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABN12886 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000039865
  ENSPPAP00000039865.1
  ENSPPAP00000039875.1
RefSeq Acc Id: XP_003812370   ⟸   XM_003812322
- UniProtKB: A0A2R9CD52 (UniProtKB/TrEMBL),   A0A2R9CD61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000039865   ⟸   ENSPPAT00000062777
RefSeq Acc Id: ENSPPAP00000039875   ⟸   ENSPPAT00000062787
Protein Domains
TNF family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062777.1 UniProtKB/TrEMBL
  ENSPPAT00000062787.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro CD40L UniProtKB/TrEMBL
  TNF_CS UniProtKB/TrEMBL
  TNF_dom UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
KEGG Report pps:100975410 UniProtKB/TrEMBL
NCBI Gene CD40LG ENTREZGENE
PANTHER PTHR11471:SF5 UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR FAMILY MEMBER UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PIRSF TNF_5 UniProtKB/TrEMBL
PRINTS CD40LIGAND UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/TrEMBL
UniProt A0A2R9CD52 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CD61 ENTREZGENE, UniProtKB/TrEMBL