TIAM1 (TIAM Rac1 associated GEF 1) - Rat Genome Database

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Gene: TIAM1 (TIAM Rac1 associated GEF 1) Pan paniscus
Analyze
Symbol: TIAM1
Name: TIAM Rac1 associated GEF 1
RGD ID: 11701296
Description: ENCODES a protein that exhibits ephrin receptor binding (ortholog); microtubule binding (ortholog); phospholipid binding (ortholog); INVOLVED IN activation of GTPase activity (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); cardiac muscle hypertrophy (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); genetic disease (ortholog); FOUND IN axonal growth cone (ortholog); dendritic spine (ortholog); extrinsic component of postsynaptic density membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: collagen alpha-1(I) chain-like; LOC129394954; rho guanine nucleotide exchange factor TIAM1; T cell lymphoma invasion and metastasis 1; T-cell lymphoma invasion and metastasis 1; T-lymphoma invasion and metastasis-inducing protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22227,233,667 - 27,675,376 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12122,092,736 - 22,319,849 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02117,483,273 - 17,925,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12130,868,308 - 31,213,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2130,868,308 - 31,016,883 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TIAM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22227,233,667 - 27,675,376 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12122,092,736 - 22,319,849 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02117,483,273 - 17,925,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12130,868,308 - 31,213,846 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2130,868,308 - 31,016,883 (-)Ensemblpanpan1.1panPan2
TIAM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,118,418 - 31,559,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2131,118,416 - 31,559,977 (-)EnsemblGRCh38hg38GRCh38
GRCh372132,490,736 - 32,931,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,412,607 - 31,853,161 (-)NCBINCBI36Build 36hg18NCBI36
Build 342131,238,437 - 31,853,161NCBI
Celera2117,673,700 - 18,114,602 (-)NCBICelera
Cytogenetic Map21q22.11ENTREZGENE
HuRef2117,900,683 - 18,341,390 (-)NCBIHuRef
CHM1_12132,052,512 - 32,493,303 (-)NCBICHM1_1
T2T-CHM13v2.02129,486,163 - 29,927,068 (-)NCBIT2T-CHM13v2.0
Tiam1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391689,583,999 - 89,942,488 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1689,583,999 - 89,940,657 (-)EnsemblGRCm39 Ensembl
GRCm381689,787,111 - 90,145,600 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1689,787,111 - 90,143,769 (-)EnsemblGRCm38mm10GRCm38
MGSCv371689,787,356 - 89,974,944 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361689,675,971 - 89,849,686 (-)NCBIMGSCv36mm8
Celera1689,988,286 - 90,179,618 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.5NCBI
Tiam1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,517,527 - 42,866,280 (-)NCBIGRCr8
mRatBN7.21129,031,347 - 29,380,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,031,348 - 29,159,901 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1137,718,984 - 37,847,530 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,419,012 - 30,547,477 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01129,580,961 - 29,709,993 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01129,931,083 - 30,061,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1129,933,163 - 30,051,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,551,577 - 33,681,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41130,123,752 - 30,252,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11130,128,732 - 30,252,936 (+)NCBI
Celera1128,721,403 - 28,849,496 (-)NCBICelera
Cytogenetic Map11q11NCBI
Tiam1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540730,803,653 - 30,942,854 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540730,804,769 - 31,178,420 (-)NCBIChiLan1.0ChiLan1.0
TIAM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,058,858 - 26,440,059 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3125,932,697 - 26,202,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,051,519 - 26,432,492 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03126,177,246 - 26,558,745 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3126,049,131 - 26,558,793 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13126,123,696 - 26,504,723 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03126,135,327 - 26,516,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03126,641,221 - 27,022,148 (-)NCBIUU_Cfam_GSD_1.0
Tiam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497126,655,584 - 27,016,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650010,688,236 - 10,812,192 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650010,451,599 - 10,812,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13194,774,497 - 195,005,089 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113194,774,495 - 195,235,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,172,464 - 205,307,819 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIAM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1260,573,187 - 61,015,599 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl260,865,819 - 61,017,191 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660713,120,127 - 3,563,047 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tiam1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474519,561,195 - 19,760,095 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474519,563,166 - 19,941,511 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000043351   ⟹   ENSPPAP00000020556
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2130,868,308 - 31,016,883 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000043366   ⟹   ENSPPAP00000020571
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2130,870,251 - 31,016,883 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000043370   ⟹   ENSPPAP00000020575
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2130,870,251 - 30,910,082 (-)Ensembl
RefSeq Acc Id: XM_003813220   ⟹   XP_003813268
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22227,233,667 - 27,460,745 (-)NCBI
NHGRI_mPanPan12122,092,736 - 22,319,849 (-)NCBI
Mhudiblu_PPA_v02117,483,273 - 17,710,424 (-)NCBI
PanPan1.12130,868,308 - 31,094,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024926974   ⟹   XP_024782742
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22227,233,667 - 27,276,235 (-)NCBI
NHGRI_mPanPan12122,092,736 - 22,135,303 (-)NCBI
Mhudiblu_PPA_v02117,483,273 - 17,525,841 (-)NCBI
PanPan1.12130,868,308 - 30,910,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063601293   ⟹   XP_063457363
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22227,233,667 - 27,675,376 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003813268 (Get FASTA)   NCBI Sequence Viewer  
  XP_024782742 (Get FASTA)   NCBI Sequence Viewer  
  XP_063457363 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000020556.1
  ENSPPAP00000020571.1
  ENSPPAP00000020575
  ENSPPAP00000020575.1
Reference Protein Sequences
RefSeq Acc Id: XP_003813268   ⟸   XM_003813220
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024782742   ⟸   XM_024926974
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AXM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000020556   ⟸   ENSPPAT00000043351
RefSeq Acc Id: ENSPPAP00000020571   ⟸   ENSPPAT00000043366
RefSeq Acc Id: ENSPPAP00000020575   ⟸   ENSPPAT00000043370
RefSeq Acc Id: XP_063457363   ⟸   XM_063601293
- Peptide Label: isoform X1
Protein Domains
DH   PDZ   PH   RBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033381 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000043351.1 UniProtKB/TrEMBL
  ENSPPAT00000043366.1 UniProtKB/TrEMBL
  ENSPPAT00000043370.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
  6.10.140.680 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  Tiam1/Tiam2/Sif UniProtKB/TrEMBL
  TIAM1_CC-Ex UniProtKB/TrEMBL
KEGG Report pps:100967869 UniProtKB/TrEMBL
NCBI Gene TIAM1 ENTREZGENE
PANTHER PTHR46001 UniProtKB/TrEMBL
  PTHR46001:SF1 UniProtKB/TrEMBL
Pfam PDZ UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  Tiam_CC_Ex UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
SMART PDZ UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
UniProt A0A2R9ATA0_PANPA UniProtKB/TrEMBL
  A0A2R9ATB8_PANPA UniProtKB/TrEMBL
  A0A2R9AXM4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-03-14 TIAM1  TIAM Rac1 associated GEF 1  LOC129394954  collagen alpha-1(I) chain-like  Data Merged 737654 PROVISIONAL
2019-09-10 TIAM1  TIAM Rac1 associated GEF 1  TIAM1  T cell lymphoma invasion and metastasis 1  Symbol and/or name change 5135510 APPROVED
2017-12-19 TIAM1  T cell lymphoma invasion and metastasis 1    T-cell lymphoma invasion and metastasis 1  Symbol and/or name change 5135510 APPROVED