ERCC6 (ERCC excision repair 6, chromatin remodeling factor) - Rat Genome Database

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Pathways
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Gene: ERCC6 (ERCC excision repair 6, chromatin remodeling factor) Pan paniscus
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Symbol: ERCC6
Name: ERCC excision repair 6, chromatin remodeling factor
RGD ID: 11670021
Description: ENCODES a protein that exhibits DNA helicase activity (ortholog); RNA polymerase binding (ortholog); INVOLVED IN DNA damage response (ortholog); DNA protection (ortholog); DNA repair (ortholog); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH age related macular degeneration 5 (ortholog); arthrogryposis multiplex congenita (ortholog); cataract (ortholog); FOUND IN B-WICH complex (ortholog); nuclear body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA excision repair protein ERCC-6; excision repair cross-complementing rodent repair deficiency, complementation group 6; LOC100978198; piggyBac transposable element-derived protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2861,722,441 - 61,811,183 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11061,721,084 - 61,812,606 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01044,703,720 - 44,784,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
base-excision repair  (IEA)
chromatin remodeling  (IEA)
DNA damage checkpoint signaling  (IEA)
DNA damage response  (IEA,ISO)
DNA protection  (ISO)
DNA repair  (IEA,ISO)
double-strand break repair via classical nonhomologous end joining  (IEA)
double-strand break repair via synthesis-dependent strand annealing  (IEA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
JNK cascade  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of double-strand break repair via nonhomologous end joining  (IEA)
neurogenesis  (IEA)
neuron differentiation  (IEA)
neuron projection development  (IEA)
photoreceptor cell maintenance  (IEA,ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of DNA repair  (IEA)
positive regulation of DNA-templated transcription, elongation  (IEA)
positive regulation of double-strand break repair via homologous recombination  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation of STAT protein  (ISO)
positive regulation of transcription by RNA polymerase III  (IEA)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO)
pyrimidine dimer repair  (IEA,ISO)
reciprocal meiotic recombination  (IEA)
regulation of DNA-templated transcription elongation  (IEA)
regulation of transcription elongation by RNA polymerase II  (ISO)
response to gamma radiation  (IEA,ISO)
response to oxidative stress  (IEA,ISO)
response to superoxide  (IEA,ISO)
response to toxic substance  (IEA,ISO)
response to UV  (IEA,ISO)
response to UV-B  (IEA,ISO)
response to X-ray  (IEA,ISO)
single strand break repair  (IEA)
transcription elongation by RNA polymerase I  (IEA,ISO)
transcription-coupled nucleotide-excision repair  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ERCC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2861,722,441 - 61,811,183 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11061,721,084 - 61,812,606 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01044,703,720 - 44,784,948 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ERCC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381049,434,881 - 49,539,538 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1049,454,168 - 49,539,538 (-)EnsemblGRCh38hg38GRCh38
GRCh371050,642,927 - 50,747,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361050,336,715 - 50,417,078 (-)NCBINCBI36Build 36hg18NCBI36
Build 341050,336,714 - 50,417,078NCBI
Celera1044,250,656 - 44,333,241 (-)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1044,927,342 - 45,011,950 (-)NCBIHuRef
CHM1_11050,944,706 - 51,029,274 (-)NCBICHM1_1
T2T-CHM13v2.01050,283,667 - 50,388,257 (-)NCBIT2T-CHM13v2.0
Ercc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,235,248 - 32,302,947 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,235,478 - 32,302,947 (+)EnsemblGRCm39 Ensembl
GRCm381432,513,291 - 32,580,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,513,521 - 32,580,990 (+)EnsemblGRCm38mm10GRCm38
MGSCv371433,326,707 - 33,394,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,342,530 - 31,409,998 (+)NCBIMGSCv36mm8
Celera1428,771,098 - 28,837,767 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.4NCBI
Ercc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,771,311 - 7,841,895 (+)NCBIGRCr8
mRatBN7.2167,764,983 - 7,835,587 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl167,765,013 - 7,835,587 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx167,780,912 - 7,847,534 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0168,925,860 - 8,992,482 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0167,779,882 - 7,846,470 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0168,734,028 - 8,804,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl168,734,035 - 8,804,610 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,699,983 - 10,770,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,024,881 - 8,091,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,024,868 - 8,088,560 (+)NCBI
Celera167,365,531 - 7,432,176 (-)NCBICelera
Cytogenetic Map16p16NCBI
Ercc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955556748,231 - 813,133 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955556745,175 - 812,215 (+)NCBIChiLan1.0ChiLan1.0
ERCC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1281,358,383 - 1,432,276 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl281,361,107 - 1,427,162 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,593,582 - 1,667,457 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0281,534,813 - 1,608,719 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl281,534,813 - 1,608,641 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,333,055 - 1,406,921 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0281,370,132 - 1,444,015 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,502,030 - 1,575,915 (-)NCBIUU_Cfam_GSD_1.0
Ercc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721379,558,979 - 79,640,918 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936728761,804 - 844,690 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936728706,499 - 843,447 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,002,024 - 90,075,898 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11489,998,125 - 90,075,911 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21497,907,746 - 97,985,104 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ercc6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624928463,279 - 530,115 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624928458,651 - 532,201 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_003809030   ⟹   XP_003809078
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2861,722,441 - 61,810,335 (-)NCBI
NHGRI_mPanPan11061,721,084 - 61,812,606 (-)NCBI
Mhudiblu_PPA_v01044,703,749 - 44,784,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008961167   ⟹   XP_008959415
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2861,722,441 - 61,810,335 (-)NCBI
NHGRI_mPanPan11061,721,084 - 61,812,563 (-)NCBI
Mhudiblu_PPA_v01044,703,788 - 44,784,948 (+)NCBI
Sequence:
RefSeq Acc Id: XM_057298888   ⟹   XP_057154871
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2861,774,751 - 61,811,183 (-)NCBI
NHGRI_mPanPan11061,780,071 - 61,812,606 (-)NCBI
RefSeq Acc Id: XM_057298889   ⟹   XP_057154872
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2861,774,751 - 61,811,183 (-)NCBI
NHGRI_mPanPan11061,780,071 - 61,812,567 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003809078 (Get FASTA)   NCBI Sequence Viewer  
  XP_008959415 (Get FASTA)   NCBI Sequence Viewer  
  XP_057154871 (Get FASTA)   NCBI Sequence Viewer  
  XP_057154872 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000001762.1
  ENSPPAP00000001791.1
  ENSPPAP00000001806.1
Reference Protein Sequences
RefSeq Acc Id: XP_003809078   ⟸   XM_003809030
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZA95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008959415   ⟸   XM_008961167
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZA95 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_057154871   ⟸   XM_057298888
- Peptide Label: isoform X2
RefSeq Acc Id: XP_057154872   ⟸   XM_057298889
- Peptide Label: isoform X2
Protein Domains
Helicase ATP-binding   Helicase C-terminal   PiggyBac transposable element-derived protein


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000008110 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000008792.1 UniProtKB/TrEMBL
  ENSPPAT00000008911.1 UniProtKB/TrEMBL
  ENSPPAT00000008960.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10810 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PGBD UniProtKB/TrEMBL
  SNF2-like_sf UniProtKB/TrEMBL
  SNF2/RAD54-like_C UniProtKB/TrEMBL
  SNF2_N UniProtKB/TrEMBL
KEGG Report pps:100978198 UniProtKB/TrEMBL
NCBI Gene LOC100978198 ENTREZGENE
PANTHER DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED UniProtKB/TrEMBL
  PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2-RELATED UniProtKB/TrEMBL
  SNF2/RAD54 FAMILY MEMBER UniProtKB/TrEMBL
Pfam DDE_Tnp_1_7 UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  SNF2_N UniProtKB/TrEMBL
PROSITE HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A2R8Z9V9_PANPA UniProtKB/TrEMBL
  A0A2R8ZA95 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-08 ERCC6  ERCC excision repair 6, chromatin remodeling factor  LOC100978198  DNA excision repair protein ERCC-6  Symbol and/or name change 5135510 APPROVED