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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1321714
Species: Homo sapiens
RGD Object: Gene
Symbol: FLT3
Name: fms related receptor tyrosine kinase 3
Acc ID: CHEBI:90217
Term: quizartinib
Definition: A member of the class of phenylureas that is urea in which one of the amino groups has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group while the other has been substituted by a phenyl group substituted at the para- position by an imidazo[2,1-b][1,3]benzothiazol-2-yl group that, in turn, is substituted at position 7 by a 2-(morpholin-4-yl)ethoxy group.
Chemical ID: MESH:C544967
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FLT3decreases phosphorylationEXP 6480464CTDquizartinib results in decreased phosphorylation of FLT3 protein alternative formPMID:34665271
FLT3multiple interactionsEXP 6480464CTDquizartinib affects the reaction [RGFP966 results in decreased expression of and results in decreased phosphorylation of FLT3 protein alternative form]; quizartinib promotes the reaction [romidepsin results in decreased phosphorylation of FLT3 protein alternative form]; RGFP966 affects the reaction [quizartinib results in decreased phosphorylation of FLT3 protein alternative form]; romidepsin promotes the reaction [quizartinib results in decreased phosphorylation of FLT3 protein alternative form]PMID:34665271
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