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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pgr
Name: progesterone receptor
Acc ID: CHEBI:8772
Term: raloxifene
Definition: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Chemical ID: MESH:D020849
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pgrincreases expressionEXP 6480464CTDRaloxifene Hydrochloride results in increased expression of PGR proteinPMID:16837883
Pgrdecreases expressionISOPGR (Homo sapiens)6480464CTDRaloxifene Hydrochloride results in decreased expression of PGR mRNA; Raloxifene Hydrochloride results in decreased expression of PGR proteinPMID:11867264 PMID:16973256 PMID:26865669
Pgrmultiple interactionsISOPgr (Mus musculus)6480464CTD[Estradiol co-treated with Raloxifene Hydrochloride] results in increased expression of PGR mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PGR mRNA]PMID:26879975
Pgrmultiple interactionsISOPGR (Homo sapiens)6480464CTD[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PGR mRNA; [trichostatin A co-treated with Raloxifene Hydrochloride] results in decreased expression of PGR mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; trichostatin A inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PGR mRNA]PMID:21185374 PMID:22476901
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