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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310915
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mylk
Name: myosin light chain kinase
Acc ID: CHEBI:78761
Term: ML-7
Definition: An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Chemical ID: MESH:C070571
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mylkdecreases activityEXP 6480464CTDML 7 results in decreased activity of MYLK proteinPMID:17541957
Mylkmultiple interactionsEXP 6480464CTD[[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein] which results in increased secretion of REN protein; [ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 proteinPMID:18835913 PMID:9618396
Mylkdecreases activityISOMYLK (Homo sapiens)6480464CTD[ML 7 results in decreased activity of MYLK protein] which results in decreased activity of F2 protein; ML 7 results in decreased activity of MYLK proteinPMID:10733514 PMID:12534346 PMID:16675616
Mylkdecreases activityISOMylk (Mus musculus)6480464CTDML 7 results in decreased activity of MYLK proteinPMID:19943851
Mylkmultiple interactionsISOMYLK (Homo sapiens)6480464CTD[ML 7 results in decreased activity of MYLK protein] which results in decreased phosphorylation of MYL9 protein; [ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein; FADD protein affects the reaction [[ML 7 results in decreased activity of MYLK protein] which results in increased activity of CASP3 protein]; ML 7 inhibits the reaction [Calcium deficiency results in increased activity of MYLK protein]; ML 7 inhibits the reaction [Ethanol results in increased activity of MYLK protein]PMID:10198341 PMID:11054866 PMID:1643115 PMID:16723733
Mylkmultiple interactionsISOMylk (Mus musculus)6480464CTDML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK mRNA]; ML 7 inhibits the reaction [Lipopolysaccharides results in increased expression of MYLK protein]; ML 7 inhibits the reaction [MYLK protein results in increased uptake of Glucose]PMID:18773891 PMID:19374788
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