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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3403
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prl
Name: prolactin
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prldecreases expressionEXP 6480464CTDbeta-Naphthoflavone results in decreased expression of PRL mRNAPMID:22975028
Prlmultiple interactionsEXP 6480464CTDalpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of PRL mRNA]PMID:22975028
Prlmultiple interactionsISOPrl (Mus musculus)6480464CTDbeta-Naphthoflavone inhibits the reaction [[PRL protein co-treated with Dexamethasone] results in increased expression of CSN2 mRNA]; beta-Naphthoflavone inhibits the reaction [[PRL protein co-treated with Dexamethasone] results in increased expression of LALBA mRNA]; beta-Naphthoflavone inhibits the reaction [[PRL protein co-treated with Dexamethasone] results in increased expression of WAP mRNA]; beta-Naphthoflavone promotes the reaction [[PRL protein co-treated with Dexamethasone] results in increased expression of CYP1A1 mRNA]PMID:29521512
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