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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:71045
Term: bisdemethoxycurcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.
Chemical ID: MESH:C034786
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2decreases expressionISOERBB2 (Homo sapiens)6480464CTDbisdemethoxycurcumin results in decreased expression of ERBB2 proteinPMID:34291863
Erbb2increases response to substanceISOERBB2 (Homo sapiens)6480464CTDERBB2 protein results in increased susceptibility to bisdemethoxycurcuminPMID:34291863
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