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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:63892
Term: zerumbone
Definition: A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.
Chemical ID: MESH:C403304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAdecreases phosphorylationEXP 6480464CTDzerumbone results in decreased phosphorylation of RELA proteinPMID:27567548
RELAmultiple interactionsEXP 6480464CTDzerumbone inhibits the reaction [CHUK protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Hydrogen Peroxide results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; zerumbone inhibits the reaction [MAP3K14 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Okadaic Acid results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; zerumbone inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; zerumbone inhibits the reaction [TNFRSF1A protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TRADD protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone inhibits the reaction [TRAF2 protein results in increased activity of [NFKB1 protein binds to RELA protein]]; zerumbone results in decreased activity of [NFKB1 protein binds to RELA protein]PMID:16007145 PMID:27567548
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