GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP2E1 | affects response to substance | EXP | | 6480464 | CTD | CYP2E1 gene polymorphism affects the susceptibility to Isoniazid; CYP2E1 gene SNP affects the susceptibility to Isoniazid | PMID:12668988 PMID:20485159 | CYP2E1 | increases expression | EXP | | 6480464 | CTD | Isoniazid results in increased expression of CYP2E1 protein | PMID:8074729 | CYP2E1 | increases metabolic processing | EXP | | 6480464 | CTD | CYP2E1 protein results in increased metabolism of Isoniazid | PMID:17950035 | CYP2E1 | increases response to substance | EXP | | 6480464 | CTD | CYP2E1 protein results in increased susceptibility to Isoniazid | PMID:28762043 | CYP2E1 | multiple interactions | EXP | | 6480464 | CTD | GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid] | PMID:28762043 | CYP2E1 | increases activity | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | Isoniazid results in increased activity of CYP2E1 protein | PMID:12458634 PMID:15132840 PMID:15205388 PMID:19683030 PMID:23211455 PMID:25683034 PMID:26880746 PMID:9051121 PMID:9129171 | CYP2E1 | increases expression | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Isoniazid results in increased expression of CYP2E1 mRNA | PMID:22342832 | CYP2E1 | increases expression | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | Isoniazid results in increased expression of CYP2E1; Isoniazid results in increased expression of CYP2E1 mRNA; Isoniazid results in increased expression of CYP2E1 protein | PMID:11752103 PMID:15205388 PMID:15763544 PMID:20566340 PMID:24929095 PMID:25683034 PMID:3113478 PMID:9065729 | CYP2E1 | multiple interactions | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA] | PMID:22342832 | CYP2E1 | multiple interactions | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | 2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene; [Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein] | PMID:12458634 PMID:15132840 PMID:18754103 PMID:19683030 PMID:20566340 PMID:26880746 PMID:27919644 PMID:7710944 PMID:9051121 PMID:9065729 | | ||||||||||||||||||||||
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