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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases phosphorylationEXP 6480464CTDTrinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 proteinPMID:30365937 PMID:33522063
Stat3multiple interactionsEXP 6480464CTDbergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]; cinnamaldehyde inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]PMID:30365937 PMID:33522063
Stat3increases phosphorylationISOStat3 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 proteinPMID:25740948
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTDstattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]PMID:25740948
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