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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353629
Species: Homo sapiens
RGD Object: Gene
Symbol: IL12B
Name: interleukin 12B
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL12Bdecreases response to substanceISOIl12b (Mus musculus)6480464CTDIL12B protein results in decreased susceptibility to Trinitrobenzenesulfonic AcidPMID:11782017
IL12Bincreases expressionISOIl12b (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of IL12B mRNAPMID:16867261
IL12Bincreases expressionISOIl12b (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA; Trinitrobenzenesulfonic Acid results in increased expression of IL12B proteinPMID:17375199 PMID:23596210
IL12Bmultiple interactionsISOIl12b (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B mRNA]PMID:16867261
IL12Bmultiple interactionsISOIl12b (Mus musculus)6480464CTDicilin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL12B protein]PMID:23596210
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