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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1increases expressionEXP 6480464CTDnickel sulfate results in increased expression of HMOX1 mRNAPMID:16314067 PMID:19033392 PMID:20146380 PMID:20491607 PMID:20566472
HMOX1decreases expressionISOHmox1 (Mus musculus)6480464CTDnickel sulfate results in decreased expression of HMOX1 proteinPMID:25957741
HMOX1multiple interactionsISOHmox1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [nickel sulfate results in decreased expression of HMOX1 protein]PMID:25957741
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