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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:50207
Term: sophoraflavanone B
Definition: A trihydroxyflavanone that is (S)-naringenin having a prenyl group at position 8.
Chemical ID: MESH:C119737
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PGRincreases expressionEXP 6480464CTD8-prenylnaringenin results in increased expression of PGR mRNAPMID:16076101
PGRincreases expressionISOPgr (Rattus norvegicus)6480464CTD8-prenylnaringenin results in increased expression of PGR mRNA; 8-prenylnaringenin results in increased expression of PGR proteinPMID:16522720 PMID:16837889 PMID:34848279
PGRmultiple interactionsISOPgr (Rattus norvegicus)6480464CTDFulvestrant inhibits the reaction [8-prenylnaringenin results in increased expression of PGR mRNA]PMID:34848279
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