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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:47775
Term: high-density lipoprotein cholesterol
Definition: Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL).
Chemical ID: MESH:D008076
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFaffects abundanceEXP 6480464CTDTNF gene polymorphism affects the abundance of Cholesterol, HDLPMID:17823444
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTDCholesterol, HDL inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Carbon Tetrachloride] results in increased expression of TNF protein]PMID:15123356
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