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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735729
Species: Homo sapiens
RGD Object: Gene
Symbol: FOS
Name: Fos proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:4469
Term: (S)-amphetamine
Definition: A 1-phenylpropan-2-amine that has S configuration.
Chemical ID: MESH:D003913
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOSaffects expressionISOFos (Mus musculus)6480464CTDDextroamphetamine affects the expression of FOS proteinPMID:19194377
FOSincreases expressionISOFos (Mus musculus)6480464CTDDextroamphetamine results in increased expression of FOS mRNAPMID:12205029
FOSincreases expressionISOFos (Rattus norvegicus)6480464CTDDextroamphetamine results in increased expression of FOS mRNA; Dextroamphetamine results in increased expression of FOS proteinPMID:11160452 PMID:11403691 PMID:11716816 PMID:11750902 PMID:12105094 PMID:12377393 PMID:12510024 PMID:12641732 PMID:12807422 PMID:1347779 PMID:16678866
FOSmultiple interactionsISOFos (Mus musculus)6480464CTDSOD1 inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]PMID:12205029
FOSmultiple interactionsISOFos (Rattus norvegicus)6480464CTD3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Dextroamphetamine results in increased expression of FOS protein]; [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [FOS protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] results in increased expression of FOS protein; [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOS protein; Dextroamphetamine promotes the reaction [FOS protein binds to FOS promoter]; Dextroamphetamine promotes the reaction [SRF protein binds to FOS promoter]; Dizocilpine Maleate inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; ecopipam inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; ifenprodil inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]; N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Dextroamphetamine results in increased expression of FOS protein]; SCH 23390 inhibits the reaction [Dextroamphetamine results in increased expression of FOS mRNA]PMID:12377393 PMID:12510024 PMID:12807422 PMID:16678866
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