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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:43602
Term: obeticholic acid
Definition: A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis.
Chemical ID: MESH:C464660
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1decreases expressionEXP 15045602RGDobeticholic acid decreases expression of CYP7a1 mRNA in liver in porcine serum induced model of cirrhosis in rat 
Cyp7a1multiple interactionsEXP 15036816RGDObeticholic acid inhibits the reaction [ethanol increases expression of Cyp7a1 protein in liver] 
Cyp7a1decreases expressionEXP 6480464CTDobeticholic acid results in decreased expression of CYP7A1 mRNAPMID:15644430 PMID:35267068
Cyp7a1multiple interactionsEXP 6480464CTDobeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA]PMID:32673658
Cyp7a1decreases expressionISOCYP7A1 (Homo sapiens)6480464CTDobeticholic acid results in decreased expression of CYP7A1 mRNAPMID:15911693 PMID:27939613
Cyp7a1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTDobeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP7A1 protein]; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 protein]; obeticholic acid promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]PMID:29660435 PMID:36328986 PMID:36787806
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