Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307793
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pole4
Name: DNA polymerase epsilon 4, accessory subunit
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pole4affects expressionISOPOLE4 (Homo sapiens)6480464CTDValproic Acid affects the expression of POLE4 mRNAPMID:25979313
Pole4affects expressionISOPole4 (Mus musculus)6480464CTDValproic Acid affects the expression of POLE4 mRNAPMID:17292431
Pole4decreases expressionISOPOLE4 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of POLE4 mRNAPMID:23179753 PMID:24935251 PMID:27188386 PMID:29154799
Pole4decreases methylationISOPOLE4 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of POLE4 genePMID:29154799
Pole4multiple interactionsISOPOLE4 (Homo sapiens)6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of POLE4 mRNAPMID:17183730
Go Back to source page   Continue to Ontology report