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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3186
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3multiple interactionsEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of and results in decreased phosphorylation of NOS3 proteinPMID:32980420
Nos3decreases expressionISONOS3 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in decreased expression of NOS3 mRNAPMID:32790152
Nos3increases expressionISONOS3 (Homo sapiens)6480464CTDperfluorooctane sulfonic acid results in increased expression of NOS3 mRNAPMID:22269386
Nos3multiple interactionsISONos3 (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of NOS3 mRNAPMID:36331819
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