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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:39214
Term: abamectin
Definition: Mixture of 80% avermectin B1a and 20% avermectin B1b.
Chemical ID: MESH:C048324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDabamectin results in increased expression of CYP2E1 proteinPMID:31739238
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTD[Ascorbic Acid co-treated with Sesame Oil] inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Ascorbic Acid inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]; Sesame Oil inhibits the reaction [abamectin results in increased expression of CYP2E1 protein]PMID:31739238
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