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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:38472
Term: acetonitrile
Definition: A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.
Chemical ID: MESH:C032159
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1multiple interactionsEXP 6480464CTDacetonitrile inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]PMID:9143349
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTDacetonitrile inhibits the reaction [CYP2E1 protein results in increased metabolism of 7-methoxy-4-trifluoromethylcoumarin]PMID:19858067
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