GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Adam17 | increases response to substance | EXP | | 6480464 | CTD | ADAM17 results in increased susceptibility to Tetradecanoylphorbol Acetate | PMID:12147693 | Adam17 | multiple interactions | EXP | | 6480464 | CTD | ADAM17 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of HBEGF protein]; ADAM17 protein affects the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TGFA protein] | PMID:28703301 | Adam17 | increases expression | ISO | ADAM17 (Homo sapiens) | 6480464 | CTD | Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein | PMID:23774263 PMID:26298005 | Adam17 | multiple interactions | ISO | ADAM17 (Homo sapiens) | 6480464 | CTD | [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which affects the localization of PROCR protein; [Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]] which results in decreased cleavage of and results in decreased secretion of PROCR protein; Methylthiouracil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]; Rosmarinic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ADAM17 protein]; Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]; Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein] | PMID:23774263 PMID:24632454 PMID:26298005 | |
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