Adam17 (a disintegrin and metallopeptidase domain 17) - Rat Genome Database

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Gene: Adam17 (a disintegrin and metallopeptidase domain 17) Mus musculus
Analyze
Symbol: Adam17
Name: a disintegrin and metallopeptidase domain 17
RGD ID: 731401
MGI Page MGI
Description: Enables metallodipeptidase activity and metalloendopeptidase activity. Involved in several processes, including germinal center formation; lymphocyte differentiation; and proteolysis. Acts upstream of or within negative regulation of neuron projection development; regulation of axon regeneration; and regulation of neuron migration. Located in cytoplasm and membrane. Is active in plasma membrane. Is expressed in several structures, including foregut-midgut junction; heart; lung; nervous system; and retina. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase domain 17; ADAM 17; CD156b; disintegrin and metalloproteinase domain-containing protein 17; Tac; Tace; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391221,373,510 - 21,423,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1221,373,510 - 21,423,633 (-)EnsemblGRCm39 Ensembl
GRCm381221,323,509 - 21,373,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,323,509 - 21,373,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,329,370 - 21,379,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361221,570,005 - 21,620,083 (-)NCBIMGSCv36mm8
Celera1219,527,967 - 19,579,463 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
7alpha-hydroxycholesterol  (ISO)
aceclofenac  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP)
atrazine  (ISO)
bellidifolin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Butylparaben  (ISO)
butyric acid  (ISO)
calcium dichloride  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diosgenin  (ISO)
enzacamene  (ISO)
enzalutamide  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenamic acid  (EXP)
flufenamic acid  (EXP)
FR900359  (ISO)
gemcitabine  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
lipopolysaccharide  (EXP)
melittin  (ISO)
methyl methanesulfonate  (ISO)
Methylthiouracil  (ISO)
N(6),N(6)-dimethyladenosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
nicotinic acid  (ISO)
oxycodone  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
progesterone  (ISO)
propiconazole  (EXP)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
thioacetamide  (ISO)
thymoquinone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
withaferin A  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid precursor protein catabolic process  (ISO)
B cell differentiation  (IMP)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (ISO)
cell motility  (IMP)
cellular response to high density lipoprotein particle stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
commissural neuron axon guidance  (ISO)
defense response to Gram-positive bacterium  (ISO)
germinal center formation  (IMP)
membrane protein ectodomain proteolysis  (IBA,IDA,IMP,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cold-induced thermogenesis  (IMP)
negative regulation of neuron projection development  (IGI)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
Notch receptor processing  (ISO)
Notch signaling pathway  (IBA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of T cell chemotaxis  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
production of molecular mediator involved in inflammatory response  (IDA)
protein processing  (ISO)
proteolysis  (ISO)
receptor transactivation  (ISO)
regulation of axon regeneration  (IGI)
regulation of mast cell apoptotic process  (IMP)
regulation of neuron migration  (IGI)
response to antineoplastic agent  (ISO)
response to hypobaric hypoxia  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to muscle activity  (ISO)
response to nutrient levels  (ISO)
response to xenobiotic stimulus  (IMP)
signaling receptor ligand precursor processing  (IMP,ISO)
spermatogenesis  (ISO)
spleen development  (IMP)
T cell differentiation in thymus  (IMP)
tumor necrosis factor-mediated signaling pathway  (ISO)
wound healing, spreading of epidermal cells  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior eye segment morphology  (IAGP)
abnormal aortic valve cusp morphology  (IAGP)
abnormal aortic valve flow  (IAGP)
abnormal aortic valve morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchiole epithelium morphology  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal coat/ hair morphology  (IAGP)
abnormal coat/hair pigmentation  (IAGP)
abnormal conjunctival sac morphology  (IAGP)
abnormal cornea morphology  (IAGP)
abnormal corneal epithelium morphology  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid margin morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle orientation  (IAGP)
abnormal hair growth  (IAGP)
abnormal heart valve morphology  (IAGP)
abnormal interleukin secretion  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lung saccule morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal mammary gland duct morphology  (IAGP)
abnormal mitral valve cusp morphology  (IAGP)
abnormal mitral valve morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal platelet physiology  (IAGP)
abnormal pulmonary valve morphology  (IAGP)
abnormal respiratory conducting tube morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal skin condition  (IAGP)
abnormal skin morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal tricuspid valve morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal vibrissa morphology  (IEA)
absent corneal endothelium  (IAGP)
absent Descemet membrane  (IAGP)
absent Meibomian glands  (IAGP)
absent myocardial trabeculae  (IAGP)
absent Schlemm's canal  (IAGP)
anophthalmia  (IAGP)
anterior iris synechia  (IAGP)
aortic valve hypertrophy  (IAGP)
aortic valve stenosis  (IAGP)
aphakia  (IAGP)
cataract  (IAGP)
corneal opacity  (IAGP)
corneal scarring  (IAGP)
curly vibrissae  (IAGP)
cyanosis  (IAGP)
decreased B cell number  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mass  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating tumor necrosis factor level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased cornea thickness  (IAGP)
decreased fetal weight  (IAGP)
decreased hematocrit  (IAGP)
decreased length of long bones  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased spongiotrophoblast size  (IAGP)
decreased survivor rate  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased T cell number  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased transforming growth factor beta level  (IAGP)
dermatitis  (IAGP)
dilated respiratory conducting tube  (IAGP)
distorted hair follicle pattern  (IAGP)
dry skin  (IAGP)
early eyelid opening  (IAGP)
enhanced leukocyte tethering or rolling  (IAGP)
enlarged aortic valve  (IAGP)
enlarged atrioventricular valve  (IAGP)
enlarged esophagus  (IAGP)
enlarged heart  (IAGP)
enlarged pulmonary valve  (IAGP)
enlarged semilunar valve  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
eye opacity  (IAGP)
eyelids open at birth  (IAGP)
failure of eyelid fusion  (IAGP)
female infertility  (IAGP)
impaired skin barrier function  (IAGP)
increased body weight  (IEA)
increased bone marrow cell number  (IAGP)
increased bone mineral content  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased erythrocyte cell number  (IAGP)
increased heart left ventricle size  (IAGP)
increased heart left ventricle weight  (IAGP)
increased heart rate  (IAGP)
increased heart ventricle size  (IAGP)
increased heart weight  (IAGP)
increased hemoglobin content  (IAGP)
increased IgE level  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased interleukin-10 secretion  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased myocardial fiber size  (IAGP)
increased neutrophil cell number  (IAGP)
increased pruritus  (IAGP)
increased spleen red pulp amount  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased T-helper 1 cell number  (IAGP)
increased T-helper 17 cell number  (IAGP)
increased T-helper 2 cell number  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
internal hemorrhage  (IAGP)
lens vacuoles  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
microphthalmia  (IAGP)
myeloid hyperplasia  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
nuchal edema  (IAGP)
osteoporosis  (IAGP)
pale lung  (IAGP)
pathological neovascularization  (IAGP)
perinatal lethality  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
pulmonary hypoplasia  (IAGP)
pulmonary valve hypertrophy  (IAGP)
reduced male fertility  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
short femur  (IAGP)
short vibrissae  (IAGP)
skin inflammation  (IAGP)
thick aortic valve  (IAGP)
thick aortic valve cusps  (IAGP)
thick lung-associated mesenchyme  (IAGP)
thick mitral valve  (IAGP)
thick pulmonary valve  (IAGP)
thick pulmonary valve cusps  (IAGP)
thick tricuspid valve  (IAGP)
thick tricuspid valve cusps  (IAGP)
thick ventricular wall  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
thrombocytosis  (IAGP)
ventricular septal defect  (IAGP)
waved hair  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. ADAMs: key components in EGFR signalling and development. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
2. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. Cardellini M, etal., Diabetes. 2009 Jul 6.
3. The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. Chalaris A, etal., Eur J Cell Biol. 2011 Jun-Jul;90(6-7):484-94. Epub 2010 Dec 8.
4. Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis. Colon AL, etal., Cytokine 2001 Dec 21;16(6):220-6.
5. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
6. Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. Geng L, etal., Exp Mol Pathol. 2010 Aug;89(1):72-81. Epub 2010 May 26.
7. A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. Hartl D, etal., Mol Psychiatry. 2018 Jul 9. pii: 10.1038/s41380-018-0091-8. doi: 10.1038/s41380-018-0091-8.
8. Role of ADAM-17, p38 MAPK, cathepsins, and the proteasome pathway in the synthesis and shedding of fractalkine/CX3 CL1 in rheumatoid arthritis. Jones BA, etal., Arthritis Rheum. 2013 Nov;65(11):2814-25. doi: 10.1002/art.38095.
9. Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. Liechti FD, etal., Infect Immun. 2014 Apr;82(4):1710-8. doi: 10.1128/IAI.00073-14. Epub 2014 Feb 3.
10. MGDs mouse GO annotations MGD data from the GO Consortium
11. MGD IEA MGD IEA
12. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
13. Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans. Monroy A, etal., Diabetologia. 2009 Jul 25.
14. ADAM17 up-regulation in renal transplant dysfunction and non-transplant-related renal fibrosis. Mulder GM, etal., Nephrol Dial Transplant. 2012 May;27(5):2114-22. doi: 10.1093/ndt/gfr583. Epub 2011 Oct 19.
15. Reverse right ventricular structural and extracellular matrix remodeling by estrogen in severe pulmonary hypertension. Nadadur RD, etal., J Appl Physiol (1985). 2012 Jul;113(1):149-58. doi: 10.1152/japplphysiol.01349.2011. Epub 2012 May 24.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. An essential role for ectodomain shedding in mammalian development. Peschon JJ, etal., Science 1998 Nov 13;282(5392):1281-4.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Plumb J, etal., J Neuroimmunol. 2005 Jul;164(1-2):1-9.
21. Canonical transforming growth factor-ß signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning. Rybnikova E, etal., Neurosci Res. 2012 Apr;72(4):364-73. doi: 10.1016/j.neures.2011.12.010. Epub 2012 Jan 2.
26. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. Sahin U, etal., J Cell Biol. 2004 Mar 1;164(5):769-79.
27. Tumor necrosis factor signaling. Wajant H, etal., Cell Death Differ. 2003 Jan;10(1):45-65.
28. Effects of aluminium on ß-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain. Wang L, etal., Neurochem Res. 2014 Jul;39(7):1338-45. doi: 10.1007/s11064-014-1317-z. Epub 2014 May 3.
29. Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression. Zeng SY, etal., Can J Cardiol. 2013 Oct;29(10):1310-9. doi: 10.1016/j.cjca.2013.04.026. Epub 2013 Jul 11.
Additional References at PubMed
PMID:8889548   PMID:9034190   PMID:9034191   PMID:9598327   PMID:9755855   PMID:9774383   PMID:10187843   PMID:10224132   PMID:10349636   PMID:10375622   PMID:10393218   PMID:10433800  
PMID:10523497   PMID:10656920   PMID:10725249   PMID:10799547   PMID:10882063   PMID:10922068   PMID:11032903   PMID:11042159   PMID:11076861   PMID:11108241   PMID:11217851   PMID:11254358  
PMID:11544199   PMID:11733179   PMID:11823465   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12711607   PMID:12773386   PMID:12814936   PMID:12878595   PMID:12904583   PMID:14499647  
PMID:14515145   PMID:14610273   PMID:14625290   PMID:14638693   PMID:14673146   PMID:14761956   PMID:15066986   PMID:15345652   PMID:15365312   PMID:15574878   PMID:15691827   PMID:15739225  
PMID:15782199   PMID:15817462   PMID:15907280   PMID:15923650   PMID:15936750   PMID:15985531   PMID:16054021   PMID:16079154   PMID:16079176   PMID:16141072   PMID:16141073   PMID:16179345  
PMID:16199880   PMID:16214147   PMID:16294222   PMID:16332269   PMID:16332693   PMID:16380418   PMID:16438938   PMID:16735599   PMID:16806063   PMID:16809777   PMID:16942750   PMID:17079736  
PMID:17169360   PMID:17244710   PMID:17245433   PMID:17344430   PMID:17371977   PMID:17510296   PMID:17567983   PMID:17572069   PMID:17646208   PMID:17709479   PMID:17804806   PMID:17884817  
PMID:17904861   PMID:17982061   PMID:18040288   PMID:18355445   PMID:18356551   PMID:18364436   PMID:18367087   PMID:18393804   PMID:18625725   PMID:18650320   PMID:18687778   PMID:18713734  
PMID:18722532   PMID:18762577   PMID:18799693   PMID:18818406   PMID:18824549   PMID:19005070   PMID:19027012   PMID:19176481   PMID:19201862   PMID:19201900   PMID:19250983   PMID:19258599  
PMID:19296470   PMID:19346138   PMID:19426283   PMID:19457070   PMID:19482949   PMID:19494263   PMID:19574220   PMID:19581512   PMID:19704010   PMID:19705113   PMID:19737556   PMID:19759332  
PMID:19767822   PMID:19827603   PMID:19827604   PMID:19846666   PMID:19877183   PMID:19965619   PMID:20026129   PMID:20110534   PMID:20154226   PMID:20194968   PMID:20220092   PMID:20236926  
PMID:20359533   PMID:20421303   PMID:20529858   PMID:20603312   PMID:20610799   PMID:20628198   PMID:20644114   PMID:20800622   PMID:20803506   PMID:20976004   PMID:20976179   PMID:20980382  
PMID:21041656   PMID:21079048   PMID:21097655   PMID:21205794   PMID:21267068   PMID:21273553   PMID:21407195   PMID:21411748   PMID:21421844   PMID:21454673   PMID:21519143   PMID:21603616  
PMID:21628404   PMID:21666671   PMID:21677750   PMID:21722904   PMID:21785222   PMID:21828049   PMID:21837653   PMID:21871134   PMID:21873635   PMID:21900081   PMID:22009748   PMID:22033402  
PMID:22055939   PMID:22101895   PMID:22246777   PMID:22246778   PMID:22284418   PMID:22319556   PMID:22357929   PMID:22384041   PMID:22479555   PMID:22565824   PMID:22575642   PMID:22610140  
PMID:22623356   PMID:22696231   PMID:22772468   PMID:22898814   PMID:22965144   PMID:22975374   PMID:23105116   PMID:23147225   PMID:23211830   PMID:23228566   PMID:23251384   PMID:23274494  
PMID:23342154   PMID:23348744   PMID:23349978   PMID:23354118   PMID:23563789   PMID:23564510   PMID:23584255   PMID:23637177   PMID:23639813   PMID:23657465   PMID:23661674   PMID:23678045  
PMID:23732913   PMID:23755270   PMID:23779109   PMID:23801765   PMID:23817563   PMID:23868980   PMID:23888051   PMID:23955337   PMID:23955714   PMID:23979594   PMID:24006456   PMID:24135057  
PMID:24140644   PMID:24142516   PMID:24197832   PMID:24223177   PMID:24227779   PMID:24275664   PMID:24286866   PMID:24336074   PMID:24338472   PMID:24342803   PMID:24404197   PMID:24462774  
PMID:24498290   PMID:24548422   PMID:24574341   PMID:24625128   PMID:24652767   PMID:24812125   PMID:24833351   PMID:24871629   PMID:24898499   PMID:24899059   PMID:24952961   PMID:25032849  
PMID:25085885   PMID:25108021   PMID:25186737   PMID:25218057   PMID:25236578   PMID:25245289   PMID:25308957   PMID:25384035   PMID:25412626   PMID:25461404   PMID:25546423   PMID:25572963  
PMID:25738567   PMID:25756182   PMID:25795784   PMID:25902485   PMID:25918388   PMID:26019295   PMID:26136458   PMID:26155844   PMID:26175156   PMID:26183206   PMID:26242473   PMID:26283731  
PMID:26338334   PMID:26359498   PMID:26441236   PMID:26527864   PMID:26561568   PMID:26651291   PMID:26815118   PMID:27059842   PMID:27077118   PMID:27089454   PMID:27113764   PMID:27161080  
PMID:27224017   PMID:27237127   PMID:27330189   PMID:27349870   PMID:27354212   PMID:27476853   PMID:27480833   PMID:27550917   PMID:27573075   PMID:27601030   PMID:27642633   PMID:27852742  
PMID:27929373   PMID:27993561   PMID:28004058   PMID:28004780   PMID:28062509   PMID:28104813   PMID:28432785   PMID:28473444   PMID:28703301   PMID:28705384   PMID:28751722   PMID:28814605  
PMID:28823868   PMID:28849138   PMID:28877252   PMID:28947615   PMID:29045841   PMID:29166602   PMID:29196099   PMID:29304540   PMID:29472497   PMID:29560122   PMID:29618514   PMID:29688375  
PMID:29751002   PMID:29776906   PMID:29891514   PMID:29897333   PMID:29897336   PMID:29925524   PMID:29930147   PMID:29966664   PMID:30022999   PMID:30111646   PMID:30154402   PMID:30354220  
PMID:30355783   PMID:30550785   PMID:30586315   PMID:30833304   PMID:30851378   PMID:30926166   PMID:30940840   PMID:30973865   PMID:31209506   PMID:31257400   PMID:31262819   PMID:31366620  
PMID:31455669   PMID:31564162   PMID:31640947   PMID:31655089   PMID:31676723   PMID:31771880   PMID:31851405   PMID:31951006   PMID:31974202   PMID:32060096   PMID:32103528   PMID:32130031  
PMID:32554809   PMID:32679831   PMID:32751103   PMID:32892692   PMID:32932701   PMID:33181031   PMID:33227998   PMID:33303781   PMID:33383559   PMID:33673337   PMID:33882688   PMID:33957124  
PMID:34051616   PMID:34073747   PMID:34075077   PMID:34370360   PMID:34509473   PMID:34526403   PMID:34610348   PMID:34613632   PMID:34718985   PMID:34751824   PMID:34767447   PMID:34884897  
PMID:34896343   PMID:34919140   PMID:34937930   PMID:35008648   PMID:35110388   PMID:35247391   PMID:35354403   PMID:35909160   PMID:36215509   PMID:36476876   PMID:36720499   PMID:36733457  
PMID:36881291   PMID:37046278   PMID:37121509   PMID:37170687   PMID:37282854   PMID:37402364   PMID:38172445  


Genomics

Comparative Map Data
Adam17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391221,373,510 - 21,423,633 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1221,373,510 - 21,423,633 (-)EnsemblGRCm39 Ensembl
GRCm381221,323,509 - 21,373,632 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1221,323,509 - 21,373,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371221,329,370 - 21,379,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361221,570,005 - 21,620,083 (-)NCBIMGSCv36mm8
Celera1219,527,967 - 19,579,463 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.3NCBI
ADAM17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3829,488,486 - 9,555,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl29,488,486 - 9,556,732 (-)EnsemblGRCh38hg38GRCh38
GRCh3729,628,615 - 9,695,959 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3629,546,843 - 9,613,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 3429,580,010 - 9,646,496NCBI
Celera29,541,264 - 9,607,791 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef29,474,897 - 9,541,735 (-)NCBIHuRef
CHM1_129,558,781 - 9,625,197 (-)NCBICHM1_1
T2T-CHM13v2.029,513,510 - 9,580,869 (-)NCBIT2T-CHM13v2.0
Adam17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8646,601,583 - 46,663,690 (-)NCBIGRCr8
mRatBN7.2640,872,936 - 40,920,700 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl640,872,856 - 40,920,639 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx641,195,035 - 41,242,751 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,509,725 - 41,557,442 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0640,942,985 - 40,990,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,400,525 - 43,448,280 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,400,528 - 43,448,280 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0660,268,228 - 60,315,989 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4641,882,432 - 41,930,755 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1641,885,557 - 41,933,881 (-)NCBI
Celera640,160,004 - 40,207,760 (-)NCBICelera
Cytogenetic Map6q16NCBI
Adam17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,180,252 - 5,218,216 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554875,180,241 - 5,218,298 (-)NCBIChiLan1.0ChiLan1.0
ADAM17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,969,633 - 117,037,769 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,974,220 - 117,041,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A9,478,080 - 9,545,363 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A9,641,194 - 9,708,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A9,641,201 - 9,708,054 (-)Ensemblpanpan1.1panPan2
ADAM17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1176,589,874 - 6,638,788 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl176,589,878 - 6,638,731 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha176,517,667 - 6,566,403 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0176,687,702 - 6,737,271 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl176,687,697 - 6,737,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1176,580,977 - 6,629,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0176,583,178 - 6,631,850 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0176,597,002 - 6,645,753 (-)NCBIUU_Cfam_GSD_1.0
Adam17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,109,736 - 51,148,960 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365325,864,867 - 5,904,003 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365325,864,851 - 5,904,005 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,795,426 - 126,853,995 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13126,795,513 - 126,853,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23135,176,533 - 135,222,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11498,092,093 - 98,157,657 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1498,092,044 - 98,157,217 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604514,163,022 - 14,230,392 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624969212,321 - 253,328 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624969212,089 - 254,532 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam17
1630 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3227
Count of miRNA genes:766
Interacting mature miRNAs:970
Transcripts:ENSMUST00000064536, ENSMUST00000101551, ENSMUST00000127974, ENSMUST00000132339, ENSMUST00000141799, ENSMUST00000142092, ENSMUST00000145118, ENSMUST00000155115
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
12792982Fbmd4_mfemoral bone mineral density 4, females only (mouse)121004319424365136Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
10043977Obq34_mobesity QTL 34 (mouse)Not determined121514733149147331Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
26884413Bzwq9_mbi-zygomatic width QTL 9, 10 week (mouse)121615000147746783Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
15039339Nmrs29_mNAFLD-associated magnetic resonance shift 29 (mouse)121782585251825852Mouse
10043848Hdlq90_mHDL QTL 90 (mouse)Not determined121783993951840081Mouse
1300870Ath18_matherosclerosis 18 (mouse)Not determined121825996652260067Mouse
12904956Edlmmq10_mextensor digitorum longus muscle mass QTL 10 (mouse)121973983353739833Mouse

Markers in Region
Adam17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A1.3UniSTS
cM Map123.0UniSTS
RH70698  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381221,325,022 - 21,325,171UniSTSGRCm38
MGSCv371221,330,883 - 21,331,032UniSTSGRCm37
Cytogenetic Map12A1.3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001277266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_102380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_120376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030246530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB021709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC140457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC156032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ007365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK139471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK214287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC114999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM248808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA325381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX220689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000064536   ⟹   ENSMUSP00000067953
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,373,518 - 21,423,633 (-)Ensembl
GRCm38.p6 Ensembl1221,323,517 - 21,373,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000101551   ⟹   ENSMUSP00000099087
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,373,510 - 21,423,594 (-)Ensembl
GRCm38.p6 Ensembl1221,323,509 - 21,373,593 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127974   ⟹   ENSMUSP00000136677
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,373,518 - 21,423,594 (-)Ensembl
GRCm38.p6 Ensembl1221,323,517 - 21,373,593 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,380,074 - 21,382,522 (-)Ensembl
GRCm38.p6 Ensembl1221,330,073 - 21,332,521 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141799
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,375,527 - 21,379,291 (-)Ensembl
GRCm38.p6 Ensembl1221,325,526 - 21,329,290 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142092   ⟹   ENSMUSP00000136255
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,399,904 - 21,423,535 (-)Ensembl
GRCm38.p6 Ensembl1221,349,903 - 21,373,534 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145118   ⟹   ENSMUSP00000136407
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,373,518 - 21,423,594 (-)Ensembl
GRCm38.p6 Ensembl1221,323,517 - 21,373,593 (-)Ensembl
RefSeq Acc Id: ENSMUST00000155115
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,377,981 - 21,394,230 (-)Ensembl
GRCm38.p6 Ensembl1221,327,980 - 21,344,229 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232107   ⟹   ENSMUSP00000155990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,373,812 - 21,423,540 (-)Ensembl
GRCm38.p6 Ensembl1221,323,811 - 21,373,539 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232526   ⟹   ENSMUSP00000155953
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1221,374,955 - 21,423,524 (-)Ensembl
GRCm38.p6 Ensembl1221,324,954 - 21,373,523 (-)Ensembl
RefSeq Acc Id: NM_001277266   ⟹   NP_001264195
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391221,373,510 - 21,423,633 (-)NCBI
GRCm381221,323,509 - 21,373,632 (-)NCBI
Celera1219,527,926 - 19,579,463 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001291871   ⟹   NP_001278800
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391221,373,510 - 21,423,633 (-)NCBI
GRCm381221,323,509 - 21,373,632 (-)NCBI
Celera1219,527,926 - 19,579,463 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009615   ⟹   NP_033745
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391221,373,510 - 21,423,633 (-)NCBI
GRCm381221,323,509 - 21,373,632 (-)NCBI
MGSCv371221,329,370 - 21,379,452 (-)RGD
Celera1219,527,926 - 19,579,463 (+)NCBI
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_102380
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391221,373,510 - 21,423,633 (-)NCBI
GRCm381221,323,509 - 21,373,632 (-)NCBI
Celera1219,527,926 - 19,579,463 (+)NCBI
Sequence:
RefSeq Acc Id: NR_120376
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391221,373,510 - 21,423,633 (-)NCBI
GRCm381221,323,509 - 21,373,632 (-)NCBI
Celera1219,527,926 - 19,579,463 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030246530   ⟹   XP_030102390
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391221,373,681 - 21,423,611 (-)NCBI
GRCm381221,323,531 - 21,373,610 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001264195 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278800 (Get FASTA)   NCBI Sequence Viewer  
  NP_033745 (Get FASTA)   NCBI Sequence Viewer  
  XP_030102390 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC62934 (Get FASTA)   NCBI Sequence Viewer  
  AAD09627 (Get FASTA)   NCBI Sequence Viewer  
  AAD09628 (Get FASTA)   NCBI Sequence Viewer  
  AAH94655 (Get FASTA)   NCBI Sequence Viewer  
  AAI15000 (Get FASTA)   NCBI Sequence Viewer  
  AAI38417 (Get FASTA)   NCBI Sequence Viewer  
  AAI38421 (Get FASTA)   NCBI Sequence Viewer  
  AAI45271 (Get FASTA)   NCBI Sequence Viewer  
  BAA78578 (Get FASTA)   NCBI Sequence Viewer  
  BAE23464 (Get FASTA)   NCBI Sequence Viewer  
  BAE24023 (Get FASTA)   NCBI Sequence Viewer  
  BAE25740 (Get FASTA)   NCBI Sequence Viewer  
  BAE28792 (Get FASTA)   NCBI Sequence Viewer  
  BAE28991 (Get FASTA)   NCBI Sequence Viewer  
  BAE38362 (Get FASTA)   NCBI Sequence Viewer  
  CAA07480 (Get FASTA)   NCBI Sequence Viewer  
  EDL34015 (Get FASTA)   NCBI Sequence Viewer  
  EDL34016 (Get FASTA)   NCBI Sequence Viewer  
  EDL34017 (Get FASTA)   NCBI Sequence Viewer  
  EDL34018 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000067953
  ENSMUSP00000067953.7
  ENSMUSP00000099087
  ENSMUSP00000099087.4
  ENSMUSP00000136255.2
  ENSMUSP00000136407.2
  ENSMUSP00000136677.2
  ENSMUSP00000155953.2
  ENSMUSP00000155990.2
GenBank Protein Q9Z0F8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_033745   ⟸   NM_009615
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q9R1U4 (UniProtKB/Swiss-Prot),   Q505A7 (UniProtKB/Swiss-Prot),   O88726 (UniProtKB/Swiss-Prot),   Q9Z0K3 (UniProtKB/Swiss-Prot),   Q9Z0F8 (UniProtKB/Swiss-Prot),   Q3UV09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264195   ⟸   NM_001277266
- Peptide Label: isoform 2 precursor
- UniProtKB: E9PXU2 (UniProtKB/TrEMBL),   Q3UNK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278800   ⟸   NM_001291871
- Peptide Label: isoform 4
- UniProtKB: Q9Z0F8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030102390   ⟸   XM_030246530
- Peptide Label: isoform X1
- UniProtKB: B7ZNJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000136407   ⟸   ENSMUST00000145118
RefSeq Acc Id: ENSMUSP00000136677   ⟸   ENSMUST00000127974
RefSeq Acc Id: ENSMUSP00000099087   ⟸   ENSMUST00000101551
RefSeq Acc Id: ENSMUSP00000155990   ⟸   ENSMUST00000232107
RefSeq Acc Id: ENSMUSP00000155953   ⟸   ENSMUST00000232526
RefSeq Acc Id: ENSMUSP00000067953   ⟸   ENSMUST00000064536
RefSeq Acc Id: ENSMUSP00000136255   ⟸   ENSMUST00000142092
Protein Domains
Disintegrin   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0F8-F1-model_v2 AlphaFold Q9Z0F8 1-827 view protein structure

Promoters
RGD ID:6822660
Promoter ID:MM_KWN:11292
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000049770,   OTTMUST00000049771
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361221,335,081 - 21,336,047 (-)MPROMDB
RGD ID:6822661
Promoter ID:MM_KWN:11293
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000049773
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361221,337,896 - 21,338,997 (-)MPROMDB
RGD ID:6822659
Promoter ID:MM_KWN:11294
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000049769
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361221,348,946 - 21,349,447 (-)MPROMDB
RGD ID:8677996
Promoter ID:EPDNEW_M17028
Type:initiation region
Name:Adam17_1
Description:Mus musculus a disintegrin and metallopeptidase domain 17 , transcriptvariant 3, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381221,373,538 - 21,373,598EPDNEW
RGD ID:6822662
Promoter ID:MM_KWN:11295
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000049766,   OTTMUST00000049767,   OTTMUST00000049772,   OTTMUST00000049774,   UC007NDV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361221,379,316 - 21,380,107 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1096335 AgrOrtholog
Ensembl Genes ENSMUSG00000052593 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064536 ENTREZGENE
  ENSMUST00000064536.13 UniProtKB/Swiss-Prot
  ENSMUST00000101551 ENTREZGENE
  ENSMUST00000101551.10 UniProtKB/TrEMBL
  ENSMUST00000127974.8 UniProtKB/TrEMBL
  ENSMUST00000142092.2 UniProtKB/TrEMBL
  ENSMUST00000145118 ENTREZGENE
  ENSMUST00000145118.8 UniProtKB/Swiss-Prot
  ENSMUST00000232107.2 UniProtKB/TrEMBL
  ENSMUST00000232526.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.70.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ADAM10_ADAM17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADAM17_MPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11491 UniProtKB/Swiss-Prot
MGD MGI:1096335 ENTREZGENE
NCBI Gene 11491 ENTREZGENE
PANTHER ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADAM17_MPD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Disintegrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reprolysin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adam17 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART DISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A338P6F3_MOUSE UniProtKB/TrEMBL
  A0A338P6I8_MOUSE UniProtKB/TrEMBL
  ADA17_MOUSE UniProtKB/Swiss-Prot
  B2RRI1_MOUSE UniProtKB/TrEMBL
  B2RRI4_MOUSE UniProtKB/TrEMBL
  B7ZNJ0 ENTREZGENE, UniProtKB/TrEMBL
  E9PXU2 ENTREZGENE, UniProtKB/TrEMBL
  J3QMF2_MOUSE UniProtKB/TrEMBL
  J3QNB3_MOUSE UniProtKB/TrEMBL
  O88726 ENTREZGENE
  Q3TMS9_MOUSE UniProtKB/TrEMBL
  Q3UEC0_MOUSE UniProtKB/TrEMBL
  Q3UEW9_MOUSE UniProtKB/TrEMBL
  Q3UNK7 ENTREZGENE, UniProtKB/TrEMBL
  Q3UV09 ENTREZGENE, UniProtKB/TrEMBL
  Q505A7 ENTREZGENE
  Q9R1U4 ENTREZGENE
  Q9Z0F8 ENTREZGENE
  Q9Z0K3 ENTREZGENE
UniProt Secondary O88726 UniProtKB/Swiss-Prot
  Q505A7 UniProtKB/Swiss-Prot
  Q9R1U4 UniProtKB/Swiss-Prot
  Q9Z0K3 UniProtKB/Swiss-Prot