Gene: Adam17 (a disintegrin and metallopeptidase domain 17)  Mus musculus
Symbol: Adam17
Name: a disintegrin and metallopeptidase domain 17
Description: ENCODES a protein that exhibits metallopeptidase activity; integrin binding (ortholog); interleukin-6 receptor binding (ortholog); INVOLVED IN B cell differentiation; cell motility; germinal center formation; PARTICIPATES IN interleukin-6 signaling pathway; Notch signaling pathway; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH abnormal anterior eye segment morphology; abnormal aortic valve cusp morphology; abnormal aortic valve flow; ASSOCIATED WITH Aortic Aneurysm, Thoracic (ortholog); Diabetes Mellitus, Type 2 (ortholog); Encephalomyelitis (ortholog); FOUND IN cytoplasm; actin cytoskeleton (ortholog); apical plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme; a disintegrin and metalloproteinase domain 17; ADAM 17; CD156b; disintegrin and metalloproteinase domain-containing protein 17; OTTMUSP00000023111; OTTMUSP00000023112; Tace; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme
Orthologs: Homo sapiens : ADAM17 (ADAM metallopeptidase domain 17)  HGNC
Rattus norvegicus : Adam17 (ADAM metallopeptidase domain 17)
Latest Assembly: Mouse Genome Assembly Build 37
Position:
MapChrPositionStrandSource
Mouse Genome Assembly GRCm381221,323,509 - 21,373,591-NCBI
Mouse cM Map128.3 NCBI
Mouse Celera Assembly1219,527,967 - 19,579,463+NCBI
Mouse Genome Assembly Build 371221,329,370 - 21,379,452-NCBI
Mouse Genome Assembly Build 36.11221,329,370 - 21,379,452-NCBI
Mouse Cytogenetic Map12 A1.3 NCBI
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RGD Object Information
RGD ID: 731401
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2013-04-30
Status: ACTIVE



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