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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:3647
Term: chlorpromazine
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID: MESH:D002746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases activityISOCYP1B1 (Homo sapiens)6480464CTDChlorpromazine results in decreased activity of CYP1B1 proteinPMID:33814510
Cyp1b1decreases response to substanceISOCYP1B1 (Homo sapiens)6480464CTDCYP1B1 protein results in decreased susceptibility to ChlorpromazinePMID:26477383
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]PMID:29724254
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