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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735684
Species: Mus musculus
RGD Object: Gene
Symbol: Slc31a1
Name: solute carrier family 31, member 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc31a1increases expressionISOSLC31A1 (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of SLC31A1 mRNAPMID:24614111
Slc31a1multiple interactionsISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 mutant form inhibits the reaction [cobaltous chloride results in decreased expression of CDH1 protein]; SLC31A1 mutant form inhibits the reaction [cobaltous chloride results in increased expression of VIM mRNA]PMID:26174737
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