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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1decreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of CYP2E1 mRNAPMID:35163327
Cyp2e1multiple interactionsEXP 6480464CTD[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of CYP2E1 mRNAPMID:35163327
Cyp2e1affects expressionISOCyp2e1 (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of CYP2E1 mRNAPMID:19429403
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased activity of CYP2E1 proteinPMID:35121066
Cyp2e1decreases expressionISOCyp2e1 (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of CYP2E1 mRNAPMID:17681415
Cyp2e1decreases expressionISOCYP2E1 (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased expression of CYP2E1 mRNAPMID:35548680
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDDietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of CYP2E1 mRNA]PMID:23626681
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