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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2448
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctsl
Name: cathepsin L
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctslaffects expressionEXP 6480464CTDCadmium Chloride affects the expression of CTSL mRNAPMID:22110744
Ctsldecreases methylationEXP 6480464CTDCadmium Chloride results in decreased methylation of CTSL promoterPMID:22457795
Ctslincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of CTSL proteinPMID:15618353
Ctslincreases cleavageISOCTSL (Homo sapiens)6480464CTDCadmium Chloride results in increased cleavage of CTSL proteinPMID:25639782
Ctslmultiple interactionsISOCtsl (Mus musculus)6480464CTD[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CTSL mRNAPMID:19840844
Ctslmultiple interactionsISOCTSL (Homo sapiens)6480464CTD2-aminoethoxydiphenyl borate inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein]; 3-methyladenine inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein]; chloroquine diphosphate inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein]; Thapsigargin inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein]PMID:25639782
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